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| 1 | Hepatitis B virus and micro RNAs:Complex interactions affecting hepatitis B virus replication and hepatitis B virusassociated diseases显示文摘Chronic infection with the hepatitis B virus(HBV) is the leading risk factor for the development of hepatocellular carcinoma(HCC). With nearly 750000 deaths yearly, hepatocellular carcinoma is the second highest cause of cancer-related death in the world. Unfortunately, the molecular mechanisms that contribute to the development of HBV-associated HCC remain incompletely understood. Recently, micro RNAs(mi RNAs), a family of small non-coding RNAs that play a role primarily in post-transcriptional gene regulation, have been recognized as important regulators of cellular homeostasis, and altered regulation of mi RNA expression has been suggested to play a significant role in virus-associated diseases and the development of many cancers. With this in mind, many groups have begun to investigate the relationship between mi RNAs and HBV replication and HBV-associated disease. Multiple findings suggest that some mi RNAs, such as mi R-122, and mi R-125 and mi R-199 family members, are playing a role in HBV replication and HBV-associated disease, including the development of HBV-associated HCC. In this review, we discuss the current state of our understanding of the relationship between HBV and mi RNAs, including how HBV affects cellular mi RNAs, how these mi RNAs impact HBV replication, and the relationship between HBV-mediated mi RNA regulation and HCC development. We also address the impact of challenges in studying HBV, such as the lack of an effective model system for infectivity and a reliance on transformed cell lines, on our understanding of the relationship between HBV and mi RNAs, and proposepotential applications of mi RNA-related techniques that could enhance our understanding of the role mi RNAs play in HBV replication and HBV-associated disease, ultimately leading to new therapeutic options and improved patient outcomes. | Jason Lamontagne Laura F Steel Michael J Bouchard | 2015 | World Journal of Gastroenterology2015，21，24： | 17 |
| 2 | Mechanism of gold and silver species on activated carbon显示文摘 | Jia Y F Steele J Hayward P | 1998 | Carbon1998，36，9： | 1 |
| 3 | Current clinical immunother- apy targets in advanced nonsmall cell lung cancer(NSCLC)显示文摘 | McCarthy F Roshani R Steele J | 2013 | J Leukoc Biol2013，94，6： | 1 |
| 4 | A new continuous catheter delivery system显示文摘 | STEELE S M KLEIN S M D'ERCOLE F J | 1998 | Anesth Analg1998，87，1： | 1 |
| 5 | Transcriptomic analysis reveals calcium regulation of specific promoter motifs in Arabidopsis 显示文摘 | Whalley H J Sargeant A W Steele J F | 2011 | Plant Cell2011，23，11： | 1 |
| 6 | Attenuation of pollutants in municipal landfill leachate by passage through clay显示文摘 | GRIFFIN R A SHIMP N F STEELE J D | 1976 | Environmental Science & Technology1976，10，13： | 1 |
| 7 | Combinatorial antibody libraries from survivors of the Turkish HSN1 avian influenza outbreak reveal virus neutralization strategies显示文摘 | Kashyap A K Steel J Ner A F | 2008 | Proc Natl Acad Sci U S A2008，105，16： | 1 |
| 8 | Bayesian stochastic frontier a- nalysis using WinBUGS 显示文摘 | JIM E GRIFFIN MARK F J STEEL | 2007 | Journal of Productivity Analysis2007，27，5： | 1 |
| 9 | Comparison of 2 different regimens for reactogenicity, safety, and immunogenicity of the live attenuated oral rotavirus vaccine RIX4414 coadmi- nistered with oral polio vaccine in South African infants 显示文摘 | Steele AD Reynders J Schohz F et ol | 2010 | J Infect Dis2010，，： | 1 |
| 10 | The components of output growth : A stochastic frontier analysis 显示文摘 | Koop G Osiewalski J Steel M F J | 1999 | Ox- ford Bulletin of Economics and Statistics1999，61，4： | 1 |
| 11 | Heahh-related quality of life in patients with muhiple injuries and traumatic }rain injury 10+ years postinjury 显示文摘 | Steel J Youssef M Pfeifer f/ | 2010 | J Trauma2010，69，3： | 1 |
| 12 | On bayesian modeling of fat tails and skewness显示文摘 | Fernandez C Steel M F J | 1998 | Journal of the American Statistical Association1998，93，441： | 1 |
| 13 | Metaplastic breast carcinomas are basal-like turnouts显示文摘 | Reis-Fillo J S Milanezi F Steele D | 2006 | Histipathology2006，，1： | 1 |
| 14 | Benchmark Priors for Bayesian Model Averaging显示文摘 | Fernandez C Ley E Steel M F J | 2001 | Journal of Econometrics2001，100，2： | 1 |
| 15 | On Bayesian modeling of fat tails and skewness显示文摘 | Fernandez C Steel M F J | 1998 | Journal of the American Statistical Association1998，93，441： | 1 |
| 16 | Sorption of arsenic,cadmium,and lead by chars produced from fast pyrolysis of wood and bark during bio-oil production显示文摘 | Mohan D Pittman C.U Bricka M Smith F Yancey B Mohammad J Steele P.H Alexandre-Franco M.F Gómez-Serrano V Gong H | | 0，，01： | 1 |
| 17 | Revised stochastic analysis of an input-output model显示文摘 | RAA Thijs ten STEEL Mark F J | 1994 | Regional Science and Urban Economics1994，24，3： | 1 |
| 18 | Vaginal and oral epithelial cell anti-Candida activity显示文摘 | Nomanbhoy F Steele C Yano J | 2002 | Infect Immun2002，70，12： | 1 |
| 19 | Partial protection against experimental vaginal candidiasis after mucosal vaccination with heat-killed Candida albicans and the mucosal adjuvant LT(R192G) 显示文摘 | Cardenas F L Steele C Wormley F L J | 2002 | Med Mycol2002，40，3： | 1 |
| 20 | Sorption of arsenic, cadmium, and lead by chars produced from fast pyrolysis of wood and bark during bio-oil production 显示文摘 | Mohan D Pittman C U Bricka M Smith F Yancey B Mohammad J Steele P H Alexandre-Franco M F Gomez-Serrano V Gong H | 2007 | Journal of Colloid Interface Science2007，310，： | 1 |
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