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| 1 | 导致儿童期肥胖的生命早期危险因素:队列研究显示文摘目的确定早年(3岁以内)导致英国儿童肥胖的危险因素。设计前瞻性队列研究。方法Avon英国父母及儿童纵向调查研究。参与者参与队列研究的8234名年龄为7岁的儿童以及亚组的909名重点儿童,后者需额外提供与早期发育有关并涉及可能导致肥胖的各种资料。诊断标准7岁儿童体重指数≥95百分位确定为肥胖,参考1990年英国人口调查的诊断标准。结果经过最终验证,在假设的25项危险因素中有8项与肥胖有关:父母肥胖(父母双方校正后的相对危险度10.44,95%可信区间5.11~21.32);最早期(43个月内)的体重指数或体重反弹升高(校正后的相对危险度15.00,95%可信区间5.32~42.30);3岁时每周看电视的时间超过8小时(校正后的相对危险度1.55,95%可信区间1.13~2.12);追赶性生长(校正后的相对危险度2.60,95%可信区间1.09~6.16);8个月(校正后的相对危险度3.13,95%可信区间1.43~6.85)和18个月(校正后的相对危险度2.65,95%可信区间1.25~5.59)时体重的标准差值;1岁时体重增加值(校正后的相对危险度1.06,95%可信区间1.02~1.10,体重每增加100g);出生体重,每100g(校正后的相对危险度1.05,95%可信区间1.03~1.07);3岁时睡眠不足(<10.5小时,校正后的相对危险度1.45,95%可信区间1.10~1.89)。结论儿童期肥胖可能与8项危险因素有关。 | John J Reilly Julie Amstrong Ahmad R Dorosty Pauline M Emmett A Ness I Rogers Colin Steer Andrea Sherriff Children Study Team 冯凯 | 2005 | 英国医学杂志中文版2005，8，5： | 8 |
| 2 | Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing显示文摘AIM:To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem cells.METHODS:In this study,we have used an immortal porcine liver stem cell line,PICM-19,to study the role of c-MYC in hepatocarcinogenesis.PICM-19 cells were converted into cancer cells(PICM-19-CSCs)by overexpressing human MYC.To identify MYC-driven differential gene expression,transcriptome sequencing was carried out by RNA sequencing,and genes identified by this method were validated using real-time PCR.In vivo tumorigenicity studies were then conducted by injecting PICM-19-CSCs into the flanks of immunodeficient mice.RESULTS:Our results showed that MYC-overexpressing PICM-19 stem cells formed tumors in immunodeficient mice demonstrating that a single oncogene was sufficient to convert them into cancer cells(PICM-19-CSCs).By using comparative bioinformatics analyses,we have determined that>1000 genes were differentially expressed between PICM-19 and PICM-19-CSCs.Gene ontology analysis further showed that the MYCinduced,altered gene expression was primarily associated with various cellular processes,such as metabolism,cell adhesion,growth and proliferation,cell cycle,inflammation and tumorigenesis.Interestingly,six genes expressed by PICM-19 cells(CDO1,C22orf39,DKK2,ENPEP,GPX6,SRPX2)were completely silenced after MYC-induction in PICM-19-CSCs,suggesting that the absence of these genes may be critical for inducingtumorigenesis.CONCLUSION:MYC-driven genes may serve as promising candidates for the development of hepatocellular carcinoma therapeutics that would not have deleterious effects on other cell types in the liver. | Rajagopal N Aravalli Neil C Talbot Clifford J Steer | 2015 | World Journal of Gastroenterology2015，21，7： | 3 |
| 3 | The role and regulation of COX-2 during viral infection 显示文摘 | Steer S A Corbett J A | 2003 | Viral Immunol2003，16，4： | 1 |
| 4 | Predicting outcomes following hospitali- zation for acute exacerbations of COPD 显示文摘 | Steer J Gibson GJ Bourke SC | 2010 | QJM2010，103，11： | 1 |
| 5 | Thromboembolism after insertion of the Mobin-Uddin caval filter 显示文摘 | Adelson J Steer ML Glotzer DJ | 1980 | Surgery1980，87，2： | 1 |
| 6 | Liver regeneration显示文摘 | Steer C J | | 0，，： | 1 |
| 7 | Predicting outcomes following hospitalization for acute exacerbations of COPD显示文摘 | Steer J Gibson GJ Bourke SC | 2010 | QJM2010，103，11： | 1 |
| 8 | An investigation of dose titration with darifenaein, α M3-seleetive reeeptor antagonist 显示文摘 | Steers W Coreos J Foote J | 2005 | BJU International2005，95，4： | 1 |
| 9 | The global burden of group A streptococcal diseases显示文摘 | Carapetis J R Steer A C Mulholland E K | | 0，，11： | 1 |
| 10 | Alterations in neural pathyways to the urinary bladder of the rat in response to streptozotocin-induced diabetes显示文摘 | Mackway-Gerardi AM Ciambotti J | 1994 | J Auton Neru Syst1994，47，12： | 1 |
| 11 | Maternal blood pressure in pregnancy,birth weight,and perinatal mortality in first births:prospective study显示文摘 | STEER P J LITTLE M P KOLD JENSEN T | 2004 | BMJ2004，329，7478： | 1 |
| 12 | CaImodulin confers calcium sensitivity on secretory exocytosis显示文摘 | Steer M W Alderton J M | 1982 | Nature1982，295，： | 1 |
| 13 | High levels of inflammatory chemo- kines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis显示文摘 | Shin J J Glickstein L J Steere AC | 2007 | Arthritis Rheum2007，56，4： | 1 |
| 14 | An improved MTT assay显示文摘 | Sladowski D Steer S J Clothier RH | 1993 | Journal of Immunologjcal Methods1993，157，12： | 1 |
| 15 | Prolonged disease-free survival afrer orthotopic liver transplantation plus adjuvant chemoirradiation for cholangiocarcinoma显示文摘 | De Vreede I Steers J L Burch P A | 2000 | Liver Transpl2000，6，： | 1 |
| 16 | Effects of stimulus and cell type on the expression of the -308 tumour necrosis factor promoter polymorphism显示文摘 | KROEGER K M STEER J H JOYCE D A | 2000 | Cytokine2000，12，2： | 1 |
| 17 | Hopelessness,depression,suicidal ideation,and clinical diagnosis of depression显示文摘 | Steer R A Beck J S | 1993 | Suicide Life Threat Behav1993，23，2： | 1 |
| 18 | Phycovirus SM-1,a virus infecting unicellular blue-green algae显示文摘 | Safferman R S Schnerder J R Steere R L | 1969 | Virology1969，37，： | 1 |
| 19 | Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis 显示文摘 | Qiao J Bush KT Steer DL | 2001 | Mech Dev2001，109，2： | 1 |
| 20 | Varicella-zoster infacfion after allogeneic bone marrow transplantation: incidence,risk factors and prevention with low-dose acyclovir and ganciclovir 显示文摘 | Steer CB Szer J Sasadeusz J | 2000 | Bone Marrow Transplant2000，25，6： | 1 |
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