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| 1 | Palliative chemotherapy for gastroesophageal cancer in old and very old patients: A retrospective cohort study at the National Center for Tumor Diseases, Heidelberg显示文摘AIM:To investigate the outcome of palliative chemotherapy in old patients with gastroesophageal cancer at the National Center for Tumor Diseases,Heidelberg.METHODS:Using a prospectively generated database,we retrospectively analyzed 55 patients≥70years under palliative chemotherapy for advanced gastroesophageal cancer at the outpatient clinic of the National Center for Tumor Diseases Heidelberg,Germany between January 2006 and December2013.Further requirements for inclusion were(1)histologically proven diagnosis of gastroesophageal cancer;(2)advanced(metastatic or inoperable)disease;and(3)no history of radiation or radiochemotherapy.The clinical information included Eastern Cooperative Oncology Group performance status(ECOG PS),presence and site of metastases at diagnosis,date of previous surgery and perioperative chemotherapy,start and stop date of first-line treatment,toxicities and consecutive dosage reductions of first-line treatment,response to first-line therapy,date of progression,usage of second-line therapies and date and cause of death.Survival times[progression-free survival(PFS),overall survival(OS)and residual survival(RS)]were calculated.Toxicity and safety were examined.Prognostic factors including ECOG PS,age and previousperioperative treatment were analyzed.RESULTS:Median age of our cohort was 76 years.86%of patients received a combination of two cytotoxic drugs.76 percent of patients had an oxaliplatin-based first-line therapy with the oxaliplatin and 5-fluorouracil regimen being the predominantely chosen regimen(69%).Drug modifications due to toxicity were necessary in 56%of patients,and 11%of patients stopped treatment due to toxicities.Survival times of our cohort are in good accordance with the major phaseⅢtrials that included mostly younger patients:PFS and OS were 5.8 and 9.5 mo,respectively.Survival differed significantly between patient groups with low(≤1)and high(≥2)ECOG PS(12.7 mo vs 3.8 mo,P<0.001).Very old patients(≥75 years)did not show a worse outcome in terms of survival.Patients receiving secondline treatment(51%)had a significantly longer RS than patients with best supportive care(6.8 vs 1.4 mo,P=0.001).Initial ECOG PS was a strong prognostic factor for PFS,OS and RS.CONCLUSION:Old patients with non-curable gastroesophageal cancer should be offered chemotherapy,and ECOG PS is a tool for balancing benefit and harm upfront.Second-line treatment is reasonable. | Anne Katrin Berger Stefanie Zschaebitz Christine Komander Dirk Jger Georg Martin Haag | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 2 | Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice显示文摘 | Collins Meredith A Bednar Filip Zhang Yaqing Brisset Jean-Christophe Galbán Stefanie Galbán Craig J Rakshit Sabita Flannagan Karen S Adsay N Volkan di Magliano Marina Pasca | 2012 | EN2012，，： | 3 |
| 3 | Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma显示文摘 | Mert Erkan Carolin Reiser-Erkan Christoph W. Michalski Stefanie Deucker Danguole Sauliunaite Sylvia Streit Irene Esposito Helmut Friess J?rg Kleeff | 2009 | Neoplasia2009，，： | 2 |
| 4 | Intraoperative laser fluorescence angiography in colorectal surgery: a noninvasive analysis to reduce the rate of anastomotic leakage显示文摘 | Stefanie Kudszus Christian Roesel Alexander Schachtrupp J?rg J. H?er | 2010 | Langenbeck’s Archives of Surgery2010，，8： | 2 |
| 5 | Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress 显示文摘 | Park DS Morris E J Stefanis L | 1998 | J Neurosci1998，18，3： | 1 |
| 6 | Laid off, But Still Loyal: The Influence of Perceived Justice And Organizational Support显示文摘 | STEFANIE E NAUMANN NATHAN BENNETT ROBERT BIES J | 1998 | International Journal of Conflict Management1998，9，4： | 1 |
| 7 | Character- ization of epoxy foams显示文摘 | STEFANI P M BARCHI A T SABUGAL J | 2003 | Journal of Applied Polymer Sci- ence2003，90，11： | 1 |
| 8 | Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging显示文摘 | Hannes G. Kenngott Martin Wagner Matthias Gondan Felix Nickel Marco Nolden Andreas Fetzer Jürgen Weitz Lars Fischer Stefanie Speidel Hans-Peter Meinzer Dittmar B?ckler Markus W. Büchler Beat P. Müller-Stich | 2014 | Surgical Endoscopy2014，，3： | 1 |
| 9 | Cyclophosphamide alters the clinical andpathological expression of experimental autoimmune gray matter disesase显示文摘 | Stefani E Appel SH | 1991 | J Neuroinxnunol1991，34，： | 1 |
| 10 | Deposition of composite titanic vanadia thin films by chemical bath deposition显示文摘 | Rudolf C H lars P H J Stefanie W | 2004 | Chem Vialer2004，16，22： | 1 |
| 11 | Correlation between plasma FLT3-1igand concentration and hematopoiesis during G-CSF-induced CD34^+ cell mobilization 显示文摘 | Bertho JM Prat M Stefani J | 2008 | Stem Cells Dev2008，17，6： | 1 |
| 12 | Theoretical and Numerical Approaches to the Forward Problem and Sensitivity Calculation of a Novel Contactless Inductive Flow Tomography (CIFT)显示文摘 | Yin Wuliang Peyton A J Stefani F | 2009 | Measurement Science and Technology2009，，10： | 1 |
| 13 | Inherent toxicity of aggregates implies a co mmon mechanism for protein misfolding diseases显示文摘 | Bucciantini M Giannoni E Chiti F Baroni F Formigli L Zurdo J Taddei N Ramponi G Dobson C M Stefani M | 2002 | Nature2002，416，： | 1 |
| 14 | Fundamental differences in the dynamics of CNS lesion development and composition in MP4 - and MOG peptide 35-55-induced experimentalautoimmune encephalomyelitis 显示文摘 | Stefanie K Sita J Magdalena T | 2008 | Clinical Immunology2008，，2： | 1 |
| 15 | Peer, self and tutor assessment: Relative reliabilities显示文摘 | Stefani L A J | 1994 | Studies in Higher Education1994，19，1： | 1 |
| 16 | Experiments to measure gouging thresh- old velocity for various metals against copper显示文摘 | Stefani F Parker J V | 1999 | IEEE Trans- actions on Magnetics1999，35，1： | 1 |
| 17 | Characterization of epoxy foams 显示文摘 | Stefani P M Barchi A T Sabugal J el al | 2003 | Journal of Applied Polymer Science2003，90，： | 1 |
| 18 | Supervisory run-to-run control of polysilicon gate etch using in situ ellipsometry 显示文摘 | BUTLER S W STEFANI J A | 1994 | IEEE Transactions on Semiconductor Manufacturing1994，7，2： | 1 |
| 19 | Hippocampal volume reduction in schizophrenia: effects of genetic risk on pregnancy and birth complications显示文摘 | Stefanis N Frangou S Yakeley J | 1996 | Biol Psychiatry1996，46，： | 1 |
| 20 | Opioids decrease high-voltage activated calcium currents in acutely dissociated neostriatal neurons 显示文摘 | Stefani A Surmeier D J Bernardi G | 1994 | Brain Res1994，642，12： | 1 |
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