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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | 连续油管电缆安装系统的开发显示文摘开发出了一个可以缠绕在卷筒上的连续油管内注入、注出电力电缆安装系统。介绍了该安装系统的油田需求、开发此系统所用理论、该安装系统的各部分装置以及应用案例。该电缆安装系统工作压力为51.72 MPa(7 500 psi),与以前的安装方法相比,大大降低了电缆安装成本,完全满足在较长连续油管内安装电缆的需求。 | 杨社民 NEWMAN K R HAVER N A STONE L R | 2015 | 焊管2015，38，10： | 2 |
| 3 | Silicon single electron memory cell 显示文摘 | Stone N J Ahmed H | 1998 | Appl Phys Lett1998，73，15： | 1 |
| 4 | The Marketing Characteristics of Involvement 显示文摘 | Stone R N | 1984 | Advances in Consumer Research1984，11，1： | 1 |
| 5 | Tbe diversity and phylogeography of cynipid gallwasps (Hymenoptera:Cynipidae) of the oriental and eastern Palearctic regions,and their associated communities显示文摘 | Abe Y Melika G Stone G N | | 0，，01： | 1 |
| 6 | Anti-Jo-1 antibody levels correlate with disease activity in idiopathic inflammatory myopathy显示文摘 | Stone KB Oddis CV Fertig N | 2007 | Arthritis Rheum2007，56，9： | 1 |
| 7 | Perceived risk:Further consider- ation for the marketing discipline显示文摘 | Stone I N Gronhaug K | 1993 | European Journal of Market- ing1993，27，： | 1 |
| 8 | Catalysis at the metal-support interface exemplified by the photocatalytic reforming of methanol on Pd/TiO2显示文摘 | BOWKER M JAMES D STONE P BENNETT R PERKINS N MILLARD L GREAVES J DICKINSON A | 2003 | J Catal2003，217，2： | 1 |
| 9 | 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines显示文摘 | Stone N J Robinson J Lichtenstein AH | 2013 | J Am Coil Cardiol2013，，： | 1 |
| 10 | Chronic obstructive pulmonary disease: A modifiable risk factor for cardiovascular disease显示文摘 | Stone I S Barnes N C Petersen S E | 2012 | Heart2012，98，14： | 1 |
| 11 | Using regulation to change the market for innovation显示文摘 | Ashford N A Ayers C Stone R F | 1985 | Harvard Environmental Law Review1985，9，： | 1 |
| 12 | State abstraction discovery from irrele- vant state variables 显示文摘 | JONG N K STONE P | 2005 | IJCAI2005，8，： | 1 |
| 13 | Biochemical outcomes after prostate brachytherapy with 5 year minimal follow-up:importance of patient selection and implant quality显示文摘 | Kollmeier MA Stock RG Stone N | 2003 | Int J Radial Oncol Biol Phys2003，57，： | 1 |
| 14 | 2 -Peak and 3 -Peak Optimal Complex Networks 显示文摘 | Andr X C N Valente Abhijit Sarkar Howard A Stone | 2004 | Phy Review Letter2004，92，： | 1 |
| 15 | Role of hormonal therapy in the management of intermediate to high-risk prostate cancer treated with permanent radioactive seed implantation显示文摘 | Lee L N Stock R G Stone N N | 2002 | Int J Radiat Oncol Biol Phys2002，52，2： | 1 |
| 16 | New relationships between breast microcalcifications and cancer显示文摘 | R Baker KD Rogers N Shepherdand N Stone | 2010 | British Journal of Cancer2010，103，7： | 1 |
| 17 | Structure ofbismuth borate glasses显示文摘 | Stone C E Wright A C Sinclair R N | 2000 | Phys Chem Glasses2000，41，6： | 1 |
| 18 | Outcomes in diabetic patients undergoing primary percutaneous coronary intervention for acute anterior myocardial infarction: Results from the INFUSE‐AMI study显示文摘 | Elias A. Sanidas Sorin J. Brener Akiko Maehara Philippe Généreux Bernhard Witzenbichler Magdi El‐Omar Martin Fahy Roxana Mehran C. Michael Gibson Gregg W. Stone | 2014 | Cathet Cardiovasc Intervent2014，，5： | 1 |
| 19 | Perceived Risk: Further Considerations for the Marketing Discipline显示文摘 | Stone Robert N Gronhaug Kjel | 1993 | European Journal of Marketing1993，27，3： | 1 |
| 20 | Triglycerides and Cardiovascular Disease:A Scientific Statement From the American Heart Association显示文摘 | MILLER M STONE N J BALLANTYNE C | 2011 | Circulation2011，123，20： | 1 |
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