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| 1 | Quantification of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA in testicular tissue of infertile patients显示文摘Aim: To evaluate the quantitative detection of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA as diagnostic parameters in the workup of testicular tissue specimens from patients presenting with non-obstructive azoospemia. Methods: hTR and hTERT mRNA expression were quantified in 38 cryopreserved testicular tissue specimens by fluorescence real-time reverse transcription- polymerase chain reaction (RT-PCR)in a LightCycler(r). This was paralleled by conventional histological workup in all tissue specimens and additional semithin sectioning preparation in cases with maturation arrest ( n = 12) and Sertoli-cell-only syndrome ( n = 12). Results: The average normalized hTERT expression (NhTERT) Was 131.9 ± 48.0 copies (mean ± SD) in tissue specimens with full spermatogenesis, NhTERT = 51.2 ± 17.2 copies in those with maturation arrest and NhTERT = 2.7 ± 2.4 copies in those with Sertoli-cell-only syndrome (SCOS). The discriminant analysis showed that detection of NhTERT (NhTR) had a predictive value of 86.8 % (55.3 % ) for correct classification in one of the three histological subgroups.Conclusion: Our results demonstrate that quantitative detection of hTERT mRNA expression in testicular tissue enables a molecular-diagnostic classification of gametogenesis. Quantitative detection of hTERT in testicular biopsies is thus well suited for supplementing the histopathological evaluation. | Mark Schrader Markus Müller Rüdiger Heicappell Bernd Straub Kurt Miller | 2001 | Asian Journal of Andrology2001，3，4： | 3 |
| 2 | Design and testing of a double X-frame piezoelectric actuator显示文摘 | Hall S R Tzianetopolou T Straub F | 2000 | Smart Structures and Integrated Systems2000，3985，： | 1 |
| 3 | Prednisone chrono-therapy显示文摘 | SPIES C M CUTOLO M STRAUB R H | 2011 | Clin Exp Rheumatol2011，29，568： | 1 |
| 4 | Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia显示文摘 | Hashimoto R Straub RE Weickert CS | 2004 | Mol Psychiatry2004，9，3： | 1 |
| 5 | Effects of retigabine on rhythmic synchronous activity of human neocortical slices显示文摘 | Straub H Kohling R Hohling J | 2001 | Epilepsy Res2001，44，23： | 1 |
| 6 | A potential vul- nerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity 显示文摘 | Straub R E MacLean C J O'Neill F A | 1995 | Nat Genet1995，11，3： | 1 |
| 7 | Malignant liver tumors trea- ted with MR imaging-guided laser-induced thermotherapy: experi- ence with complications in 899 patients ( 2,520 lesions ) 显示文摘 | Vogl TJ Straub R Eichler K | 2002 | Radiology2002，225，2： | 1 |
| 8 | Correlation of nitrites in breath condensates and lung function in asthmatic children 显示文摘 | Straub DA Ehmann R Hall GL | 2004 | Pediatr Allergy Immunol2004，15，1： | 1 |
| 9 | Structure of the Arabidopsis RPM1 gene enabling dual specificity disease resistance显示文摘 | GRANT M R GODIARD L STRAUBE E | 1995 | Science1995，269，： | 1 |
| 10 | Metabolism of arsanilic acid : Ⅰ: Metabolic stability of doubly labeled arsanilic acid in chickens 显示文摘 | OVERBY L R STRAUBE L | 1965 | Toxicol Appl Pharmacol1965，7，6： | 1 |
| 11 | Higher order aberration in normal,dilated,intraocular lens,and laser in situ keratomileusis cornea显示文摘 | Miller JM Anwaruddin R Straub J Schwiegerling J | 2002 | J Refract Surg2002，18，5： | 1 |
| 12 | Regulation of glu-eoeortieoids by the central nervous system显示文摘 | CUTOLO M BUTI'GEREIT F STRAUB R H | 2011 | Clin Exp Rhenma-tol2011，29，568： | 1 |
| 13 | Postoperative resorptive and excretory capacity of the ileal neobladder 显示文摘 | Rinnab L Straub M Hautmann R E | 2005 | BJU Int2005，95，9： | 1 |
| 14 | Laparoscpy-assisted vaginal hyslereclomy (LAVH)-a comparison between vaginal and abdominal hysterectomy with reference to intra-and postoperative quality parameters显示文摘 | Romer T Lober R Straube W | 1995 | Zentralbl Gynakol1995，117，11： | 1 |
| 15 | Flunarizine shows increased antiepileptic efficacy with elevated K^+ levels in low magnesium induced epileptic activity (neocortical slices, guinea pig)显示文摘 | Schulze-Bonhage A Kohling R Straub H | 1994 | Neuropharmaclogy1994，33，： | 1 |
| 16 | Assess- ment of rich-burn, quick-mix, lean-burn (RQL) trapped vortex combustor for stationary gas turbines 显示文摘 | Straub D L Casleton K H Lewis R E | 2005 | Transactions of the ASME2005，，127： | 1 |
| 17 | Neuropeptide Y cotmammission with norepinephrine in the sympathetic nerve - macrophage interplay 显示文摘 | Straub R H | 2000 | J Neurochem2000，75，： | 1 |
| 18 | Laser-induced thermotherapy of malignant liver tumors:general principals,equipment(s),procedure(s)-side effects,complications and results显示文摘 | Vogl TJ Eichler K Straub R | 2001 | Eur J Ultrasound2001，13，： | 1 |
| 19 | No red cell alloimmnnization or change of clinical outcome after using fresh frozen cancellous allo- graft bone for aeetabular reconstruction in revision hip arthroplasty : a follow up study 显示文摘 | Mittag F Straub M Sehafer R | 2012 | B M C Musculoskelet Disord2012，13，： | 1 |
| 20 | Exercise in the man- agement of fatigue in patients on peritoneal dialysis显示文摘 | Straub CK Murphy SO Rosenblum R | 2008 | Nephrol Nurs J2008，35，5： | 1 |
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