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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Blood-brain barrier, reperfusion injury, and hemorrhagictransformation in acute ischemic stroke显示文摘 | KHATRI R MCKINNEY AM SWENSON B | 2012 | Neurology2012，79，131： | 1 |
| 3 | Effects of preoperativeskin preparation on postoperative wound infection rates:a prosp-ective study of 3 skin preparation protocols显示文摘 | Swenson BR Hedrick TL Metzger R | 2009 | Infect Control HospEpidemiol2009，30，10： | 1 |
| 4 | Travel to high altitude with pre-existing lung disease显示文摘 | Luks A M Swenson E R | 2007 | Eur Respir J2007，29，： | 1 |
| 5 | Effects of acute and chronic acetazolamide on resting ventilation and ventilatory responses in men显示文摘 | Swenson E R Hughes J M | 1993 | J Appl Physiol1993，74，1： | 1 |
| 6 | Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression 显示文摘 | Swenson S Costa F Minea R | 2004 | Mol Cancer Ther2004，3，4： | 1 |
| 7 | Assessment of the ^137Cs method for estimating sediment accumulation rates:Louisiana salt marshes显示文摘 | Milan C S Swenson E M Turner R E | 1995 | Journal of Coastal Research1995，11，2： | 1 |
| 8 | Heat Transfer to Supercritical Water in Smooth-Bore Tubes 显示文摘 | Swenson H S Carver J R Kakarala C R | 1965 | ASME Journal of Heat Transfer Series C1965，87，4： | 1 |
| 9 | Pathogenesis of high - altitude pulmonary edema :inflammation is not an etiologic factor显示文摘 | Swenson E R Maggiorini M Mongovin S | 2002 | JAMA2002，287，17： | 1 |
| 10 | Evolu-tion of swine H3N2influenza viruses in the UnitedStates显示文摘 | Webby R J Swenson S L Krauss S L | 2000 | J Virol2000，74，18： | 1 |
| 11 | Plant DNA barcodes and a community phylogeny of a tropical forest dynamics plot in Panama 显示文摘 | Kress W J Erickson D L Jones FA Swenson N G Perez R Sanjur 0 Bermingham E | 2009 | PNAS2009，106，18： | 1 |
| 12 | Synthesis and Structures of Mono-and Bis(amidinate)Complexes of Aluminum显示文摘 | Coles M P Swenson D C Jordan R F | 1997 | Organometallics1997，16，： | 1 |
| 13 | H, t3C, and 15N backbone, side-chain, and heme chemical shift assign- ments for oxidized and reduced forms of the monoheme c-type cytochrome ApcA isolated from the acidophilic metal-reducing bacterium Acidiphilium cryptum显示文摘 | CORT J R SWENSON M W MAGNUSON T S | 2011 | Biomolecular NMR Assign- ments2011，5，1： | 1 |
| 14 | Toward calibration of regional groundwater models using GRACE data 显示文摘 | Sun A Y Green R Swenson S | 2012 | Journal of Hydrology2012，4224，23： | 1 |
| 15 | Toward calibration of re- gional groundwater models using GRACE data 显示文摘 | Sun A Y Green R Swenson S | 2012 | Journal of Hydrology2012，4224，23： | 1 |
| 16 | The role of steroid hormones in the regulation of vasopressin and oxytocin release and mRNA expression in hypothalamo-neurohypophysial explants from the rat显示文摘 | Sladek CD Swenson KL Kapoor R | 2000 | Exp Physiol2000，85，9： | 1 |
| 17 | Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression显示文摘 | Swenson S Costa F Minea R | | 0，，01： | 1 |
| 18 | Diuretic Effect of Acute Hypoxia in Humans:Relationship to Hypoxic Ventilatory Responsiveness and Renal Hormones显示文摘 | SWENSON E R DUNCAN T B GOLDBERG S V | 1995 | J Appl Physiol1995，78，： | 1 |
| 19 | Intravenous liposomal delivery of the snake venom disintegr in centortrostatin limits brrast cancer propreseion显示文摘 | SWENSON S COSTA F MINEA R | 2004 | Mol Cancer Ther2004，3，4： | 1 |
| 20 | Zinc and copper status in ewes supplemented with sulfate-and amino acid-complexed forms of zinc and copper显示文摘 | Hatfield P G Swenson C K Kott R W Ansotegui R P Roth N J Robinson B L | 2001 | Journal of Animal Science2001，79，1： | 1 |
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