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| 1 | Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations显示文摘AIM: To explore portal hypertension and portosys-temic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynam-ics. METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angio-scintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters,the liver transit time (LTT) and the circu-lation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal in? ow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS. RESULTS: The normal LTT value was 24 ± 1 s. Abnor-mal LTT had PPV = 100% for CLD. Twenty-seven non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 ± 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI < 5% (P < 0.01). PRSI > 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the clas-sifi cation of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s,PRSI < 5%). In stage 1,LTT is increased,while PRSI remains normal. In stage 2,LTT is decreased between 16 s and 23 s,whereas PRSI is increased between 5% and 10%. In stage 3,PRSI is increased to 10%-30%,and LTT becomes undetect-able by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI > 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD,stage 1 had PPV = 100% for non-cirrhotic CLD,stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis,stage 4 had PPV = 100% for cirrhosis. CONCLUSION: LTT allows the detection of early por-tal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. | Mircea Dragoteanu Ioan A Balea Liliana A Dina Cecilia D Piglesan Ioana Grigorescu Stefan Tamas Sabin O Cotul | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 2 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 3 | 乙肝病毒A1762、G1764双突变是筛选男性HBsAg携带者肝癌最高危人群的生物学标记显示文摘目的探讨乙肝病毒A1762、G1764双突变是否可作为筛选HBsAg携带者肝癌最高危人群的生物学标记。方法对2 258名乙肝病毒无症状携带者进行前瞻性队列研究,其中HBV A1762、G1764双突变株组1 261人,野毒株组997人,跟踪随访队列,每6个月1次对观察对象抽血进行甲胎蛋白(AFP)检测及B超体检以检查肝癌发病情况。结果观察48个月,2 258名乙肝病毒无症状携带者中,共发生肝癌72例,突变株组64例,野毒株组8例,发病率分别为932.2/10万人年和203.5/10万人年,两组发病率差异有统计学意义(P<0.001),相对危险度(RR)为4.58。突变株组男性发病率1 827.8/10万人年,明显高于野毒株组的180.5/10万人年,两者比较差异有统计学意义(P<0.001),相对危险度为10.13。92.5%的男性病例有双突变;突变株组女性发病率为686.6/10万人年,高于野毒株组的233.3/10万人年,两组比较差异有统计学意义(P<0.05),但相对危险度仅为2.94。结论双突变是筛选男性HBsAg携带者中肝癌最高危人群的很好生物学标记,但对女性筛选肝癌高危人群的意义不如男性。 | 王学燕 李国坚 董柏青 杨进业 陈钦艳 方孔雄 黄坚 韦少超 方钟燎 Caroline A Sabin Tim J Harrison | 2011 | 广西医学2011，33，2： | 5 |
| 4 | 隆安县乙肝病毒无症状携带者HBV前S基因缺失突变的研究显示文摘目的了解肝癌高发区隆安县乙型肝炎病毒(HBV)前S基因缺失突变株的流行情况。方法HBV表面抗原(HBsAg)无症状携带者从我们隆安县研究队列中选择,用套式聚合酶链反应对研究对象血清HBV前S基因扩增和序列分析。结果在66例标本中9例出现前S基因缺失突变,占13.6%(9/66)。9例缺失突变均为框内突变,其中7例突变发生在或涉及前S2区的5'末端。男6例、女3例出现前S基因缺失突变,但男女间突变率(12.0%,6/50与18.8%,3/16)差异无统计学意义(χ2=0.709,P>0.10);前S基因缺失突变率在基因型B、基因型C和重组基因型之间差异无统计学意义(χ2=0.002,P>0.95)。结论肝癌高发区隆安县居民HBV无症状携带者前S基因缺失突变率较高,这种突变与肝癌的关系值得进一步探讨。 | 王学燕 李国坚 董柏青 陈钦艳 方孔雄 杨进业 黄坚 韦少超 方钟燎 Caroline A Sabin Tim J Harrison | 2010 | 广西医学2010，32，2： | 4 |
| 5 | HBsAg携带者配偶乙型肝炎病毒感染状况调查显示文摘目的了解广西乙型肝炎病毒(HBV)性传播状况。方法对我们2004年建立的隆安研究队列HBsAg无症状携带者的配偶采静脉血收集血清,用酶联免疫吸附试验检测HBV血清学标志物。结果 217名研究对象中,96.8%(210/217)有过去或目前感染乙肝病毒的标记,其中32例HBsAg阳性,阳性率为14.7%(32/217),男、女阳性率分别为15.4%(14/91)和14.3%(18/126),差异无统计学意义(χ2=0.051,P>0.05);107例HBsAb阳性,阳性率为49.3%(107/217);一名男性HBsAg和HBsAb同时阳性;有79例HBsAg,anti-HBs and HBeAg阴性,这79例要么抗-HBc和抗-HBe同时阳性,要么单项阳性,但都是HBVDNA阴性;有7人(包括男性3人、女性4人)没有任何乙肝感染标记,包括HBVDNA阴性。另外,122名HBVDNA阳性的HBsAg携带者其配偶(研究对象)有14人HBsAg阳性;95名HBVDNA阴性的HBsAg携带者其配偶有18人HBsAg阳性,两者阳性率无统计学差异(χ2=2.372,P>0.05)。HBeAg阴、阳性的HBsAg携带者其配偶的HBsAg阳性率分别为15.61%(27/173)和11.76%(4/34),两者也无统计学差异(χ2=0.093,P>0.05)。结论配偶因密切接触HBsAg携带者而受HBV感染的机会比一般人群大,但性别、病毒量和HBeAg不影响其配偶感染HBV的机会。 | 王学燕 李国坚 杨进业 陈钦艳 黄坚 方孔雄 方钟燎 Caroline A Sabin Tim J Harrison | 2010 | 应用预防医学2010，16，6： | 2 |
| 6 | 乙型肝炎病毒前S缺失突变与肝癌关系的巢式匹配病例对照研究显示文摘目的了解乙型肝炎病毒(HBV)前S基因缺失突变是否是肝癌的危险因素以及它的作用是否受HBV核心基因启动子双突变的混淆影响。方法按巢式匹配病例对照研究的方法,从隆安研究队列中选择33对病例(肝癌患者)和对照(HBsAg无症状携带者),配对的条件之一是病例和对照HBV核心基因启动子序列相同,用套式聚合酶链反应(nested PCR)对研究对象血清HBV前S基因扩增和序列分析。结果肝癌患者组前S基因缺失突变率(45.5%,15/33)显著高于对照组(6/33,18.2%)(χ2=7.364,P<0.01);男女间突变率无显著性差异(28%与43.8%,χ2=1.386,P>0.05)。多因素条件logistic回归分析结果显示,前S缺失突变是肝癌的危险因素(危险比为7,95%可信区:0.861-56.894),而HBeAg,抗-HBe及肝功能则与肝癌无关。核心基因启动子双突变组与核心基因启动子野毒株组之间的前S缺失突变率无显著性差异(χ2=0.597,P>0.05)。结论HBV前S缺失突变是肝癌的独立的危险因素,它的发生及作用与核心基因启动子双突变无关。 | 王学燕 李国坚 董柏青 陈钦艳 方孔雄 杨进业 黄坚 韦少超 方钟燎 黄志碧 Caroline A Sabin Tim J Harrison | 2010 | 应用预防医学2010，16，1： | 2 |
| 7 | The accuracy of volumetric bone density measurements in dual X-ray absorptiometry 显示文摘 | SABIN M A BLAKE G M MACLAUGHLIN BLACK S M | 1995 | Calcif Tissue Int1995，56，3： | 1 |
| 8 | Hydrothermal Alteration Mapping at Bode,California,Using AVRIS Hyper Spectral Data显示文摘 | Sabin E C Taranik J V | 1998 | Remote Sensing Environ1998，65，： | 1 |
| 9 | Paralytic syndromes associated with non-inflammatory cytoplasmic or nuclear neuropathology: acute paralytic disease in Mexican children, neuropathologically distinguish- able from Landry-Guillain-Barre'syndrome显示文摘 | Ramos-Alvarez M Bessudo L Sabin A B | 1969 | JAMA1969，207，： | 1 |
| 10 | Molecular siguatures of brain injury after intracerebral hemorrhage 显示文摘 | Castillo J Davalos A AIvarez -sabin J | 2002 | Neurology2002，58，4： | 1 |
| 11 | Calcification and organic production on a Hawaiian coral reef显示文摘 | Shamberger KEF Feely R A Sabine C L et a1 | 2011 | Marine Chemistry2011，127，： | 1 |
| 12 | The oceanic sink for anthropogenic CO2 显示文摘 | Sabine C L Feely R A Gruber N | 2004 | Science2004，305，5682： | 1 |
| 13 | Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke 显示文摘 | ROSELL A ORTEGA-AZNAR A ALVAREZ- SABIN J | 2006 | Stroke2006，37，6： | 1 |
| 14 | The oceanic sink for anthropogenic CO2显示文摘 | Sabine C L Feely R A Gruber N | 2004 | Science2004，305，： | 1 |
| 15 | Valacyclovir provides optimum acyclovir exposure for prevention of cytomegalovirus and related outcomes after organ transplantation显示文摘 | Fiddian P Sabin C A Griffiths P D | 2002 | J Infect Dis2002，186，1： | 1 |
| 16 | A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke显示文摘 | Rosell A AlvarezSabin J Arenillas JF | 2005 | Stroke2005，36，： | 1 |
| 17 | Blood and graft eosinophils in acute cellular rejection of liver allografts显示文摘 | Nagral A Quaglia A Sabin CA | 2001 | Transplant Proc2001，33，4： | 1 |
| 18 | R-CHOP-14 in patients with diffuse large B-cell lymphoma younger than 70 years: a multicentre, prospective study显示文摘 | Rueda A Sabin P Rifa J | 2008 | Hematol Oncol2008，26，1： | 1 |
| 19 | Novel hydroxycarotenoids with improved antioxidative properties produced by gene combination in Escherichia coli显示文摘 | MANUELA A SHINICHI T SABINE S | 2000 | Nature Blotechnology2000，18，8： | 1 |
| 20 | Particle-mediated gene therapy of wounds显示文摘 | Jeffrey M D Thomas K Sabine A E | 2002 | Wound Rep and Reg2002，8，6： | 1 |
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