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| 1 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 2 | Cystic fibrosis mouse models显示文摘 | Guilbault C Saeed Z Downey G P | 2007 | Am J Respir Cell Mol Biol2007，36，： | 1 |
| 3 | MIMIC II: a massive temporal ICU patient database to support research in intelligent patient monitoring 显示文摘 | Saeed M Lieu C Raber G | 2002 | Comput in Cardiol2002，29，： | 1 |
| 4 | An ALMT1 gene cluster controlling alumimLm tolerance at the Alt4 locus of rye (Secale cerealeL) 显示文摘 | Collins N C Shirley N J Saeed M | 2008 | Genetics2008，179，1： | 1 |
| 5 | Helminths of red foxes (Vulpes vulpes) in Denmark显示文摘 | Saeed I Maddox-Hyttel C Monrad J | 2006 | Vet Parasitol2006，139，13： | 1 |
| 6 | Processing and characterization of microcellular foamed highdensity polyethylene/isotactic polypropylene blends 显示文摘 | Saeed Doroudiani Park C B Mark T Kortschot | 1998 | Polymer Engineering and Science1998，38，7： | 1 |
| 7 | Numerical solution of the system of linear Volterra integral equations of the second kind using Monte-Carlo method显示文摘 | Saeed R K Ahmed C S | 2008 | Journal of Applied Sciences2008，4，10： | 1 |
| 8 | Immunohistochemical expression of Pax and Bcl-2 in penile carcinoma 显示文摘 | Saeed S Keehn C A Khalil F K | 2005 | Ann Clin Lab Sci2005，35，1： | 1 |
| 9 | Transpupillary thermotherapy(TTT) for the treatment of choroidal neovascularisation显示文摘 | McAlister J C Saeed M | 2001 | Br J Ophthalmol2001，85，2： | 1 |
| 10 | Long-term benefits of testosterone replacement therapy on angina threshold and atheroma in men 显示文摘 | Mathur A Malkin C Saeed B | 2009 | Eur J Endocrinol2009，161，3： | 1 |
| 11 | Delayed presentation: negative pressure pulmonary hemorrhage显示文摘 | Saeed AI Quintana C McGuire FR | 2012 | J Clin Anesth2012，24，6： | 1 |
| 12 | Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cells显示文摘 | Zahid M Saeed M Beseler C | | 0，，01： | 1 |
| 13 | Genome-wide functions of PML-RARαin acute promyelocytic leukaemia显示文摘 | Saeed S Logie C Stunnenberg HG | 2011 | Br J Cancer2011，104，4： | 1 |
| 14 | Effects of dietary non-preferred aquatic plants on the growth reddbelly tilapia(Tilapia zilli)显示文摘 | SAEED M O ZIEBELL C D | 1986 | The Progressive Fish-Culturit1986，48，： | 1 |
| 15 | ^99mTc-labeled vasoactive intestinal peptide analog for rapid localization of tumors in humans显示文摘 | Thakur M L Marcus C S Saeed S | 2000 | J Nucl Med2000，41，1： | 1 |
| 16 | TM4 microarray software suite显示文摘 | SAEED A I BHAGABATI N K BRAISTED J C | 2006 | Methods in Enzymology2006，411，： | 1 |
| 17 | A patient-adaptive profiling scheme for ECG beat classification显示文摘 | Faezipour M Saeed A Bulusu S C | 2010 | IEEE Trans on Information Technology in Biomedicine2010，14，5： | 1 |
| 18 | Rationale and design for programming implantable eardioverter-defibril- lators in patients with primary prevention indication to prolong time to first shock (PROVIDE) study 显示文摘 | Saeed M Razavi M Neason C G | 2011 | Eu- ropace2011，13，11： | 1 |
| 19 | Immunohistochemical expression of Bax and Bcl-2 in penile carcinoma显示文摘 | Saeed S Keehn C A Khalil F K | 2005 | Annals of Clinical&Laboratory Science2005，35，1： | 1 |
| 20 | TM4 Mieroarray Software Suite显示文摘 | SAEED A I BHAGABATI N K BRAISTED J C | 2006 | Methods in En- zymology2006，411，： | 1 |
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