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| 1 | Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan显示文摘BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.AIM To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.METHODS Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(CT) Grade of the Japanese Ministry of Health, Labour, and Welfare criteria.RESULTS A total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). The area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade.CONCLUSION We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis. | Hiroaki Yasuda Keisho Kataoka Yoshifumi Takeyama Kazunori Takeda Tetsuhide Ito Toshihiko Mayumi Shuji Isaji Tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi Masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki Kihara Shigeyuki Kawa Masao Tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota Tooru Shimosegawa | 2019 | World Journal of Gastroenterology2019，25，1： | 7 |
| 2 | 前庭诱发肌源性电位对于耳硬化症患者的骨导声反应显示文摘目的:使用前庭诱发肌源性电位对骨导声反应(BC-VEMP)阐明耳硬化症患者平衡问题的起源。方法:受试者包括25例非进展性的耳硬化症患者(9例男性,16例女性),依据平衡问题的类型被分为两组。对两个组的耳蜗前庭功能的结果包括纯音测听、温度试验和BC-VEMP测试进行对比。结果:10例患者曾抱怨头晕和(或)眩晕(失调组),其他15例患者没有这种症状(非失调组)。失调组中9例患者在BC-VEMP测试中结果异常,而非失调组中1例患者结果异常(P<0.01)。结论:耳硬化症患者平衡问题的一个主要原因是球囊功能障碍。BC-VEMP的测试对于这些患者的诊断是有用的。 | NAOKI SAKA TORU SEO KIYOKO FUJIMORI YASUO MISHIRO MASAFUMI SAKAGAMI 张甦琳 孔维佳 | 2013 | 临床耳鼻咽喉头颈外科杂志2013，27，24： | 3 |
| 3 | Contributions of distinct prefrontal neuron classes in reward processing显示文摘The prefrontal cortex(PFC)is thought to be involved in higher order cognitive functions,such as in working memory,abstract categorization,and reward processing.It has been reported that two distinct neuron classes(putative pyramidal cells and interneurons)in the PFC played different functional roles in neural circuits involved in forming working memory and abstract categories.However,it remains elusive how the two types of neurons process reward information in the PFC.To investigate this issue,the activity of single neurons was extracellularly recorded in the PFC of the monkey performing a reward predicting task.PFC neurons were classified into putative pyramidal cells and interneurons,respectively,based on the waveforms of action potentials.Both the two types of neurons encoded reward information and discriminated two reward conditions(the preferred reward condition vs.the nonpreferred reward condition).However,the putative pyramidal neurons had better and more reliable discriminability than the putative interneurons.Also,the pyramidal cells represented reward information in the preferred reward condition,but not in the nonpreferred reward condition by raising their firing rates relative to the baseline rates.In contrast,the interneurons encoded reward information in the nonpreferred reward condition,but not in the preferred reward condition by inhibiting their discharge rates relative to the baseline rates.These results suggested that the putative pyramidal cells and interneurons had complementary functions in reward processing.These findings may help to clarify individual functions of each type of neurons in PFC neuronal circuits involved in reward processing. | PAN XiaoChuan FAN HongWei WANG RuBin SAKAGAMI Masamichi | 2014 | Science China(Technological Sciences)2014，57，6： | 2 |
| 4 | Morpho-Physiological Response of Oryza glaberrima to Gradual Soil Drying显示文摘Soil drought occurrence during dry season has been the main constraint, besides prolonged flooding during rainy season, in increasing cropping intensity and rice productivity in tropical riparian wetland. Use of drought tolerant rice genotype might be a suitable option for overcoming such problem. This study focused on the effects of gradual soil drying during early vegetative growth stage on morphological and physiological traits of five Oryza glaberrima genotypes, namely RAM12, RAM14, RAM59, RAM97 and RAM101, and two Oryza sativa subsp japonica genotypes, i.e. Koshihikari and Minamihatamochi. The plants were subjected to 6 d of gradual soil drying condition from 15 days after transplanting(DAT) to 20 DAT, and were allowed to recover until 22 DAT. Gradual soil drying reduced plant growth as indicated by dry mass accumulation. Drought reduced stomatal conductance and increased leaf rolling score of all the genotypes. All the genotypes showed comparable response on stomatal conductance, but O. glaberrima genotypes performed higher in leaf rolling recovery. Meanwhile, O. sativa genotypes decreased total leaf area and specific leaf area, but increased specific leaf weight in order to avoid further damages due to drought stress. Drought tolerance mechanisms in RAM101, RAM12, RAM59 and RAM14 were associated with leaf morpho-physiological responses, root traits and dry biomass accumulation. | Kartika KARTIKA Jun-Ichi SAKAGAMI Benyamin LAKITAN Shin YABUTA Andi WIJAYA Sabaruddin KADIR Laily Ilman WIDURI Erna SIAGA Yoshihiro NAKAO | 2020 | Rice science2020，27，1： | 2 |
| 5 | A Study of Vacuum-Drying Characteristics of Sugi Boxed-Heart Timber显示文摘 | Andi Hermawan Noboru Fujimoto Hiroki Sakagami | 2013 | Drying Technology2013，，5： | 2 |
| 6 | Tetrahydrobiopterin impairs the action of endothelial nitric oxide via superoxide derived from platelets显示文摘 | Tajima M Sakagami H | 2000 | Br J Pharmacol2000，131，5： | 1 |
| 7 | Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines显示文摘 | Fukai Toshio Sakagami Hiroshi Toguchi Masako | 2000 | Anticancer Res2000，20，4： | 1 |
| 8 | Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-β显示文摘 | Tsuritani K Takeda J Sakagami J | 2010 | Calcif Tissue Int2010，86，1： | 1 |
| 9 | Applications of pulse heating thermography and lock-in thermography to quantitative ondestructive evaluations显示文摘 | T Sakagami S Kubo | 2002 | Infrared Physics & technology2002，43，： | 1 |
| 10 | Steroidal glyco-sides from the leaves of Cestrum nocturnum显示文摘 | Mimaki Y Watanabe K Sakagami H | 1990 | Proc Natl ChemConf(Ⅱ)Karachi1990，32，3： | 1 |
| 11 | Mitogenic activity of pine cone extracts against cultured splenocytes from normal and tumor-bearing animals 显示文摘 | Kurakata Y Sakagami H Takeda M | 1989 | Anticancer Res1989，9，4： | 1 |
| 12 | Possible role of radical intensity and oxidation potential 显示文摘 | Sakagami H Satoh K Hatano T | 1997 | Anticancer Res1997，，17： | 1 |
| 13 | Induction of cell death by ascorbic acid derivatives in human renal carcinoma and glioblastoma cell lines显示文摘 | Makino Y Sakagami H Takeda M | 1999 | Anticancer Res1999，19，4： | 1 |
| 14 | Possible role of radical intensity and oxidation potential for gallic acid-induced apoptosis显示文摘 | Sakagami H Satoh K Hatano T | 1997 | Anticancer Res1997，17，： | 1 |
| 15 | Learning personal preferences on online newspaper articles from user behaviors 显示文摘 | Sakagami H Kamba T | 1997 | Computer Networks1997，29，813： | 1 |
| 16 | Acta Metal Mater显示文摘 | Sakagami T | 1990 | 38(6): 9091990，38，6： | 1 |
| 17 | Introduction of Cu(Ⅱ) complex into transparent synthetic resin and optical function of the resin as a nearinfrared ray cutoff fiher显示文摘 | Hiroki Katono Teruo Sakagami Masuhiro Shouji | 1998 | Journal of Applied Polymer Science1998，67，： | 1 |
| 18 | Helicobacter pyloriand gastriccancer 显示文摘 | Tanida N Sakagami T Nakamura Y | 1996 | Nih Geka Gakkai Zasshi1996，97，4： | 1 |
| 19 | Steroidal glyco-sides from the leaves of Cestrum nocturnum显示文摘 | Mimaki Y Watanabe K Sakagami H | 2002 | J Nat Prod2002，65，12： | 1 |
| 20 | Production of bioactive triterpenes by Eriobotrya japonica calli 显示文摘 | Taniguchi S Imayoshi Y Kobayashi E Takamatsu Y Ito H Hatano T Sakagami H Tokauda H Nishino H Sugita D Shisumu S Yoshida T | 2002 | Phytochemistry2002，59，： | 1 |
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