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| 1 | challenges of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is an aggressive malignancy,resulting as the third cause of death by cancer each year. The management of patients with HCC is complex,as both the tumour stage and any underlying liver disease must be considered conjointly. Although surveillance by imaging,clinical and biochemical parameters is routinely performed,a lot of patients suffering from cirrhosis have an advanced stage HCC at the first diagnosis. Advanced stage HCC includes heterogeneous groups of patients with different clinical condition and radiological features and sorafenib is the only approved treatment according to Barcelona Clinic Liver Cancer. Since the introduction of sorafenib in clinical practice,several phase Ⅲ clinical trials have failed to demonstrate any superiority over sorafenib in the frontline setting. Locoregional therapies have also been tested as first line treatment,but their role in advanced HCC is still matter of debate. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Therefore this review will focus on the range of experimental therapeutics for patients with advanced HCC and highlights the successes and failures of these treatments as well as areas for future development. Specifics such as dose limiting toxicity and safety profile in patients with liver dysfunction related to the underlying chronic liver disease should be considered when developing therapies in HCC. Finally,robust validated and reproducible surrogate end-points as well as predictive biomarkers should be defined in future randomized trials. | Stefano Colagrande Andrea L Inghilesi Sami Aburas Gian G Taliani Cosimo Nardi Fabio Marra | 2016 | World Journal of Gastroenterology2016，22，34： | 19 |
| 2 | Miniature gastrointestinal endoscopy: Now and the future显示文摘Since its original application,gastrointestinal(GI)endoscopy has undergone many innovative transformations aimed at expanding the scope,safety,accuracy,acceptability and cost-effectiveness of this area of clinical practice.One method of achieving this has been to reduce the caliber of endoscopic devices.We propose the collective term“Miniature GI Endoscopy”.In this Opinion Review,the innovations in this field are explored and discussed.The progress and clinical use of the three main areas of miniature GI endoscopy(ultrathin endoscopy,wireless endoscopy and scanning fiber endoscopy)are described.The opportunities presented by these technologies are set out in a clinical context,as are their current limitations.Many of the positive aspects of miniature endoscopy are clear,in that smaller devices provide access to potentially all of the alimentary canal,while conferring high patient acceptability.This must be balanced with the costs of new technologies and recognition of device specific challenges.Perspectives on future application are also considered and the efforts being made to bring new innovations to a clinical platform are outlined.Current devices demonstrate that miniature GI endoscopy has a valuable place in investigation of symptoms,therapeutic intervention and screening.Newer technologies give promise that the potential for enhancing the investigation and management of GI complaints is significant. | John J McGoran Mark E McAlindon Prasad G Iyer Eric J Seibel Rehan Haidry Laurence B Lovat Sarmed S Sami | 2019 | World Journal of Gastroenterology2019，25，30： | 4 |
| 3 | Prevalence of microscopic colitis in patients with diarrhea of unknown etiology in Turkey显示文摘AIM: To investigate the prevalence and demography of microscopic colitis in patients with diarrhea of unknown etiology and normal colonoscopy in Turkey. METHODS: Between March, 1998 to July, 2005, 129 patients with chronic non-bloody diarrhea of unexplained etiology who had undergone full colonoscopy with no obvious abnormalities were included in the study. Two biopsies were obtained from all colonic segments and terminal ileum for diagnosis of microscopic colitis. On histopathologic examination, criteria for lymphocytic colitis (intraepithelial lymphocyte ≥ 20 per 100 intercryptal epithelial cells, change in surface epithelium, mononuclear infiltration of the lamina propria) and collagenous colitis (subepithelial collagen band thickness ≥ 10 μm) were explored. RESULTS: Lymphocytic colitis was diagnosed in 12 (9%) patients (Female/Male: 7/5, mean age: 45 year, range: 27-63) and collagenous colitis was diagnosed in only 3 (2.5%) patients (all female, mean age: 60 years, range: 54-65).CONCLUSION: Biopsy of Turkish patients with the diagnosis of chronic non-bloody diarrhea of unexplained etiology and normal colonoscopic findings will reveal microscopic colitis in approximately 10% of the patients. Lymphocytic colitis is 4 times more frequent than collagenous colitis in these patients. | Levent Erdem Sadιk Yιldιrιm Nihat Akbayιr Banu Yιlmaz Necati Yenice Orhan Sami Gültekin nder Peker | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 4 | Novel bio-inspired approach for fault-tolerant VLSI systems 显示文摘 | Samie M Dragffy G Tyrrell A M | 2012 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems2012，21，10： | 1 |
| 5 | Non-Interactive Zero-Knowledge Proof Systems显示文摘 | De Samis A Mieali S Persiano G | 1991 | GSIAM Journal on Computing1991，20，6： | 1 |
| 6 | Using a Grounded Theory Approach for Ex- ploring Software Product Management Challenges 显示文摘 | SAMI J DONALD C G | 2014 | Journal of Systems and Software2014，，95： | 1 |
| 7 | Heterologous expression of lignin peroxiedase of Phanerochaete chrysosporium in Aspergillus niger显示文摘 | A S Mohamed S Sami G Ali | 1999 | Biotechnology Letters1999，21，： | 1 |
| 8 | Immune enhancement in rainbow trout(Oncorhynchus mykiss)by potential probiotic bacteria(Lactobacillus rhamnosus) 显示文摘 | SAMI N ARTHUR C O GRAN B | 2003 | Fish & Shellfish Immunology2003，15，： | 1 |
| 9 | Development of EST ‐ SSR markers for diversity and breeding studies in opium poppy显示文摘 | Hatice ?elale Ibrahim ?elik Visam Gültekin Jens Allmer Sami Do?anlar Anne Frary | 2013 | Plant Breed2013，，3： | 1 |
| 10 | Cyclic metamorphic memory for cellular bio-inspired electronic systems显示文摘 | SAMIE M FARJAH E DRAGFFY G | 2008 | Genetic Programming and Evolvable Machines2008，9，3： | 1 |
| 11 | Effect of temperature and pH onnonenzymic browning in minced dried pepper during storage显示文摘 | Fahrettin G Sami E | 1998 | Journal of Engineering and Environmental Science1998，，： | 1 |
| 12 | Akutes H?moperitoneum bei einer spontanen Tumorruptur als Erstmanifestation eines hepatozellul?ren Karzinoms显示文摘 | A Abdel Samie G Otto L Theilmann | 2007 | Z Gastroenterol2007，，07： | 1 |
| 13 | Laparoscopic pyeloplasty : comparison between retroperitoneoscopic and transperitoneal approach显示文摘 | Sami A Xavier G Jean-Baptiste R | 2010 | Urology2010，76，4： | 1 |
| 14 | Novel bio-in- spired approach for fault-tolerant VLSI systems 显示文摘 | SAMIE M DRAGFFY G TYRRELL A M | 2013 | IEEE Transactions on Very Large Scale Integration(VLSI) Systems2013，21，10： | 1 |
| 15 | 撞击型触发器对帽形薄壁截面轴向挤压影响的数值分析显示文摘主要介绍了触发器的设计和性能。为了分析撞击型触发器的几何特征对于轴向冲击荷载作用下耗能构件的抗挤压性能的影响,对其进行数值分析。该耗能构件由一个平盖加一个帽形顶部剖面构成。将触发器视为一个在帽形剖面上具有半圆形横截面的突起物,采用有限元软件LS-DYNA模拟所有的挤压作用。结果显示:在挤压力峰值和轴向冲击荷载作用下的构件耗能能力上,触发器的引入非常有效。同时发现,通过改变触发器的位置和几何尺寸,可以控制构件的挤压响应。 | Recep Gümrük Sami Karadeniz | 2009 | 钢结构2009，24，2： | 1 |
| 16 | Response Surface Analysis and Modeling of Flaxseed Oil Yield in Supercritical Carbon Dioxide显示文摘 | Sami G?khan ?zkal | 2009 | Journal of the American Oil Chemists’ Society2009，，11： | 1 |
| 17 | Immune enhancement in rainbow trout by potential probiotic bacteria显示文摘 | Sami N Arthur C O Gran B | 2003 | Fish & Shellfish Immunology2003，15，： | 1 |
| 18 | Heterologous expression of lignin peroxiedase of Phanerochaete chrysosporium in Aspergillus niger显示文摘 | Sami S Ali G | 1999 | Biotechnol Lett1999，21，： | 1 |
| 19 | Robust voice activity detection using higher-order statistics in the LPC residual domain显示文摘 | Elias N Rafik G Samy M | 2001 | IEEE Trans on Speech and Audio Processing2001，9，3： | 1 |
| 20 | Acute haemopentoneum due to spontaneous tomeur repture as first manifestation of hepatocellular careinoma显示文摘 | Abdel Samie A Otto G Theilmann L | 2007 | Z Gastnoenterol2007，45，7： | 1 |
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