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| 1 | Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation显示文摘AIM: To assess the agreement within 3 commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. METHODS: Twenty three infants with suspected GERD were included in this study. Symptom index (SI), Symptom sensitivity index (SSI) and symptom association probability (SAP) related to cough and irritability were calculated after 24 h combined pH/multiple intraluminal impedance (MII) monitoring. Through defined cutoff values, SI, SSI and SAP values are differentiated in normal and abnormal, whereas abnormal values point towards gastroesophageal reflux (GER) as the origin of symptoms. We analyzed the correlation and the concordance of the diagnostic classification of these 3 SAA parameters.RESULTS: Evaluating the GER-irritability association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 39.2% of the infants. When irritability was taken as a symptom, there was only a poor inter-parameter association between SI and SSI, and between SI and SAP (Kendall’s tau b = 0.37, P < 0.05; Kendall’s tau b = 0.36, P < 0.05, respectively). Evaluating the GER-cough association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 52.2% of the patients. When cough was taken as a symptom, only SI and SSI showed a poor inter-parameter association (Kendall’s tau b = 0.33, P < 0.05). CONCLUSION: In infants investigated for suspected GERD with pH/MII-monitoring, SI, SSI and SAP showed a poor inter-parameter association and important dis-agreements in diagnostic classification. These limitations must be taken into consideration when interpreting the results of SAA in infants. | Samuel C Lüthold Mascha K Rochat Peter Bhler | 2010 | World Journal of Gastroenterology2010，16，19： | 3 |
| 2 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 3 | Filtered vacuum arc deposition of semiconductor thin film 显示文摘 | Boxman R L Samuel G Shalom A B | 1995 | IEEE Trans On Plasma Science1995，23，： | 2 |
| 4 | Chemical factors for chemical-mechanical and electrochemical mechanical planarization of silver examined using potentiodynamic and impedance measurements 显示文摘 | SAMUEL B E JENNIFER L H MARIA A D | 2005 | Materials Chemistry and Physics2005，89，23： | 1 |
| 5 | 2011 ACCF/AHA/ HRS Focused Update on the Management of Patients With Atrial Fibrillation 显示文摘 | L Samuel Wann Anne B Curtis F | 2011 | J Am Coil Cardiol2011，57，2： | 1 |
| 6 | The Trichoderma koningii aggregate species 显示文摘 | SAMUELS G J DODD S L LU B S | 2006 | Studies in Mycology2006，56，： | 1 |
| 7 | Trehalose and Sucrose Protect both Membranes and Proteins in Intact Bacteria during Drying 显示文摘 | SAMUEL B L ISRAELII E BRUCE L | 1995 | Applied and Environmental Microbiology1995，61，10： | 1 |
| 8 | Trehalose and sucrose protect both membranes and proteins in intact bacteria during drying显示文摘 | | 1995 | Appfied and Environment Microbiology1995，，10： | 1 |
| 9 | Modeling of annular fluid pressures in horizontal boring 显示文摘 | SAMUEL A HARBIN B C STAUBER R L | 2007 | Tunnelling and Underground Space Technology2007，22，56： | 1 |
| 10 | Fish and shellfish allergy 显示文摘 | Wild L G Lehrer Samuel B | 2005 | Current Allergy and Asthma Reports2005，5，1： | 1 |
| 11 | Structure technology for future aerospace system显示文摘 | Noor A K Samuel L Venneri D B | 2000 | Computers and Struc- tures2000，74，5： | 1 |
| 12 | Structures technologyfor future aeros-space systems显示文摘 | Ahmed K N Samuel L V Donald B P | 2000 | Computers Structures2000，74，： | 1 |
| 13 | Reevaluating producer's and consumer's risks in acceptance sampling显示文摘 | Graves Samuel B Murphy David C Ringuest Jeffrey L | 1996 | Computers & Industrial Engineering1996，30，2： | 1 |
| 14 | Comparison of methods for evaluating pavement inter- ventions 显示文摘 | MUHAMMAD B MUHAMMAD I SAMUEL L | 2009 | Transportation Research Record: Journal of the Transportation Research Board2009，2108，03： | 1 |
| 15 | Production of alpha-1, 3-galactosyltransferase knockout pigs by nuclear transfer cloning显示文摘 | Lai L Kolber-Simonds D Park K W Cheong H T Greenstein J L Im G S Samuel M Bonk A Rieke A DayB N Murphy C N Carter D B Hawley R J Prather R S | 2002 | Science2002，295，5557： | 1 |
| 16 | Comparison of methods for evaluating pavement interventions显示文摘 | Muhammad B Muhammad I Samuel L | 2009 | Transportation Research Record: Journal of the Transpor- tation Research Board2009，2108，03： | 1 |
| 17 | Sure success partial search 显示文摘 | CHOI B S THOMAS A W SAMUEL L B | 2007 | Quantum Information Processing2007，6，1： | 1 |
| 18 | Gnotobiotic zebrafish reveal evolu- tionarily conserved responses to the gut microbiota 显示文摘 | Rawls J F Samuel B S Gordon J l | 2004 | Proceedings of the Na- tional Academy of Sciences of the United States of America2004，101，45： | 1 |
| 19 | Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation显示文摘 | Eggan K Rode A Jentsch I Samuel C Hennek T Tintrup H Zevnik B Erwin J Loring J Jackson-Grusby L Speicher MR Kuehn R Jaenisch R | 2002 | Nat Biotechnol2002，20，： | 1 |
| 20 | Amiodarone Hepatotoxicity显示文摘 | Mohamed B Samuel S L Timothy P | 2008 | Cur Vas Pharmacol2008，6，3： | 1 |
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