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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Corruption, Political Connections and Municipal Finance 显示文摘 | Butler A W Larry F Sandra M | 2009 | Review of Finance2009，，22： | 1 |
| 3 | Closed suetioning of intuba- ted neonates maintains better physiologic stability : a random- ized tria显示文摘 | Kalyn A Blatz S Sandra F | 2003 | J Perinatol2003，23，3： | 1 |
| 4 | Semi-conductor-assisted photodegradation of liglin, dye, and kraft effluent by Ag-doped ZnO 显示文摘 | Carlos A K Goerver F W Sandra G M | 2000 | Chenmosphere2000，40，4： | 1 |
| 5 | Production of surfactant from Bacillus subtilis ATCC 21332 using potato substrates显示文摘 | SANDRA L F GREG A B | 2000 | Bioresource Technology2000，75，： | 1 |
| 6 | Aqueous tape casting processing of low dielectric constant cordierite-based glass-ceramics-Selection of binder显示文摘 | MEI Sen YANG Juan XU Xin Sandra Q Simeon A Ferreirajose M F | 2006 | J Euro Ceram Soc2006，26，12： | 1 |
| 7 | Susceptibility of the cartilage collagens types Ⅱ , Ⅺ and Ⅺ to degradation by the cysteine proteinase, cathepsins B and L 显示文摘 | Sandra F W David J E | 1990 | FEBS1990，269，： | 1 |
| 8 | Compliance with hepatitis B virus vaccination and risk of occupational exposure to blood and other body fluids in intensive care department personnel in Brazil显示文摘 | Vania F.C Manso Kézia F Castro Sirley M Matos Ana Luiza N Junqueira Sandra B Souza Márcia M Sousa Regina M.B Martins Sheila A Teles | 2003 | AJIC: American Journal of Infection Control2003，，7： | 1 |
| 9 | Stir bar sorptive extraction combined with GC-MS analysis and chemometric methods for the classification of South African Wines according to the volatile composition显示文摘 | TREDOUX A DE VILLIERS A MAJEK P LYNEN F CROUCH A SANDRA P | 2008 | Agric Food Chem2008，56，12： | 1 |
| 10 | Identification and characterization of potentially algal-lytic marine bacteria strongly associated with the toxic dinoflagellate显示文摘 | ANA M A MARIA S F SANDRA R O | 2005 | Journal of Eukaryotic Microbiology2005，52，3： | 1 |
| 11 | Cholecalciferol modulates plasma phosphate but not plasma vitamin D levels and intesti- nal phosphate absorption in rainbow trout (Oncorhyrwhus mykiss ) 显示文摘 | Enrique M A Sandra P B Ronaldo P F | 1999 | Gen Comp EndocrinoI1999，114，： | 1 |
| 12 | Comparison of the adsorption mechanisms of pyridine in hydrophilic interaction chromatography and in reversed-phase aqueous liquid chromatography显示文摘 | GRITTI F PEREIRA A D S SANDRA P | 2009 | Journal of Chromatography A2009，1216，48： | 1 |
| 13 | Diabetes with coronary disease have a prevalence of asymptomatic ischemia during exercise treadmill testing and ambulatory ischemia monitoring similar to that of nondiabetic patients显示文摘 | EUGENE A C BERNARD R C SANDRA A F | 1996 | Circulation1996，93，12： | 1 |
| 14 | Determination of the rodenticides warfarin,diphenadione and chlorophacinone in soil samples by HPLC - DAD显示文摘 | Medvedovici A David F Sandra P | 1997 | Talanta1997，44，9： | 1 |
| 15 | Citric acid production from orange peel wastes by solid-state fermentation显示文摘 | Ana Mar f a Torrado Sandra Cort 6 s Jos 6 Manuel Salgado | 2011 | Brazilian Journal of Microbiology2011，42，： | 1 |
| 16 | Primary structure of arabinoxylans of ispaghula husk and wheat bran显示文摘 | Chaplin M F Sandra E Blackwood A | 2003 | Proc Nutr Soc2003，62，： | 1 |
| 17 | Aging Response of the Ti-35Nb-7Zr-5Ta and Ti-35Nb-7Ta Alloys显示文摘 | Peterson L F Flavia F C Sandra A S | 2007 | Journalof Alloys and Compounds2007，，433： | 1 |
| 18 | Aromatic composition of the Vitis vinifera grape Albario显示文摘 | Sandra C Diéguez Lucía C Lois Esperanza F Gomez | 2003 | Lebensm Wissu Technol2003，36，： | 1 |
| 19 | Stir bar sorptive extraction: A new quantitative and comprehensive sampling technique for determination of chemical signal profile from biological media显示文摘 | soini H A Bruce K E Wiesler D David F Sandra P Novotny M V | 2005 | Journal of Chemical Ecology2005，31，2： | 1 |
| 20 | human lung carcinomas express Fas ligand 显示文摘 | Gloria A N Thomas B Sandra P F | 1997 | Cancer Research1997，57，： | 1 |
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