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| 1 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 2 | Stromal expression of SPARC in pancreatic adenocarcinoma显示文摘 | Cindy Neuzillet Annemila? Tijeras-Raballand Jér?me Cros Sandrine Faivre Pascal Hammel Eric Raymond | 2013 | Cancer and Metastasis Reviews (-)2013，，3： | 4 |
| 3 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 4 | Experimental study of pulse-jet cleaning of bag filters supported by rigid rings显示文摘 | Xavier Simon Sandrine Chazelet Dominique Thomas Denis Bémer Roland Régnier | 2006 | Powder Technology2006，，2： | 2 |
| 5 | A spectral projection method for the simulation of complex three-dimensional rotating flows显示文摘 | Isabelle R Sandrine H Eric H | | 0，，： | 1 |
| 6 | Genetic diversity among alfalfa (Medicago sativa ) cultivars coming from a breeding program, using SSR markers显示文摘 | Sandrine F Joelle R Pierre B | 2005 | Theoretical and Applied Genetics2005，111，： | 1 |
| 7 | Structure and oxidation of C/C composites : role of the interface 显示文摘 | Sandrine Labruquere Xavier Bourrnt Pailer R | 2001 | Carbon2001，39，7： | 1 |
| 8 | A long-term Copper exposure on freshwater ecosystem using lotic mesocosms:Primary producer community responses显示文摘 | HéLèNE R LO(I)C T H Sandrine J | 2007 | Aquatic Toxicology2007，81，2： | 1 |
| 9 | Genetic diversity of canine olfactory receptors 显示文摘 | STEPHANIE R SANDRINE T MAUD R | 2009 | Brae Genomies2009，10，1： | 1 |
| 10 | Biochemical characterization of a recombinant TRIM5 alpha protein that restricts human immunodeficiency virus type 1 replication 显示文摘 | Langelier C R Sandrin V Eckert D M | 2008 | Joumal of Virology2008，82，11： | 1 |
| 11 | Stability of oxaliplatin solution显示文摘 | Audrey J Sandrine R Marie CD | 2009 | The Annals of Pharmacotherapy2009，43，： | 1 |
| 12 | Regulation of acp1, encoding a non-aspartyl acid protease expressed during pathogenesis of Sclerotinia sclerotiorum显示文摘 | SANDRINE C GENEVIEVE B CHRISTINE R MICHEL F | 2001 | Microbiology2001，147，： | 1 |
| 13 | Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery disease 显示文摘 | SANDRINE C STEFAN B HANS J R | 2001 | Arterioscler Thromb Vasc Biol2001，21，： | 1 |
| 14 | Acoustic radiation force impulse: a new ultrasonographic technology for the widespread noninvasive diagnosis of liver fibrosis显示文摘 | Jér?me Boursier Gael Isselin Isabelle Fouchard-Hubert Frédéric Oberti Nina Dib Jér?me Lebigot Sandrine Bertrais Yves Gallois Paul Calès Christophe Aubé | 2010 | European Journal of Gastroenterology & Hepatology2010，，9： | 1 |
| 15 | Coordination behaviour and network formation with 4,4' ,6,6'-tetracarboxy- 2,2'-bipyridine and 4,4'-diearboxy-2,2'-bipyridine ligands with rare and alkaline earth metals显示文摘 | Niamh R Kelly Sandrine Goetz Paul E Kruger | 2008 | Cryst Eng Comm2008，10，： | 1 |
| 16 | Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance,the fructose-fed rat显示文摘 | Sandrine D Eleni R M | 2005 | Atherosclerosis2005，179，： | 1 |
| 17 | Does health information matter for modifying consumption?a field experi-ment measuring the impact of risk information on fish con-sumption显示文摘 | JuTTA R STEPHAN M SANDRINE B et aL | 2009 | Review of Agricultural Economics2009，31，1： | 1 |
| 18 | Matrix effect in LC-ESI-MS and LC-APCI-MS with off-line and on-line extraction procedures显示文摘 | Sandrine S Serge R Jean LV | 2004 | J Chromatogr A2004，1058，： | 1 |
| 19 | Consequences of high transitory airflows generated by segmented pulse-jet cleaning of dust collector filter bags显示文摘 | Xavier Simon Denis Bémer Sandrine Chazelet Dominique Thomas Roland Régnier | 2010 | Powder Technology2010，，1： | 1 |
| 20 | Results of Non-operative Therapy for Delayed Hemorrhage after Pancreaticoduodenectomy显示文摘 | Laura Beyer Rémi Bonmardion Sandrine Marciano Olivier Hartung Olivier Ramis Léna?k Chabert Marc Léone Olivier Emungania Pierre Orsoni Marc Barthet Stéphane V. Berdah Christian Brunet Vincent Moutardier | 2009 | Journal of Gastrointestinal Surgery2009，，5： | 1 |
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