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| 1 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 2 | 3D additive-manufactured nanocomposite magnetic scaffolds: Effect of the application mode of a time-dependent magnetic field on hMSCs behavior显示文摘Over the past few years,the influence of static or dynamic magnetic fields on biological systems has become a topic of considerable interest.Magnetism has recently been implicated to play significant roles in the regulation of cell responses and,for this reason,it is revolutionizing many aspects of healthcare,also suggesting new opportunities in tissue engineering.The aim of the present study was to analyze the effect of the application mode of a time-dependent magnetic field on the behavior of human mesenchymal stem cells(hMSCs)seeded on 3D additivemanufactured poly(3-caprolactone)/iron-doped hydroxyapatite(PCL/FeHA)nanocomposite scaffolds. | Ugo D'Amora Teresa Russo Antonio Gloria Virginia Rivieccio Vincenzo D'Anto Giacomo Negri Luigi Ambrosio Roberto De Santis | 2017 | Bioactive Materials2017，2，3： | 3 |
| 3 | Mechanisms of altered bone remodeling in children with type 1 diabetes显示文摘Bone loss associated with type 1 diabetes mellitus(T1DM)begins at the onset of the disease,already in childhood,determining a lower bone mass peak and hence a greater risk of osteoporosis and fractures later in life.The mechanisms underlying diabetic bone fragility are not yet completely understood.Hyperglycemia and insulin deficiency can affect the bone cells functions,as well as the bone marrow fat,thus impairing the bone strength,geometry,and microarchitecture.Several factors,like insulin and growth hormone/insulin-like growth factor 1,can control bone marrow mesenchymal stem cell commitment,and the receptor activator of nuclear factor-κB ligand/osteoprotegerin and Wnt-b catenin pathways can impair bone turnover.Some myokines may have a key role in regulating metabolic control and improving bone mass in T1DM subjects.The aim of this review is to provide an overview of the current knowledge of the mechanisms underlying altered bone remodeling in children affected by T1DM. | Giacomina Brunetti Gabriele D'Amato Stefania De Santis Maria Grano Maria Felicia Faienza | 2021 | World Journal of Diabetes2021，12，7： | 3 |
| 4 | Difficult polypectomy-giant hypopharyngeal polyp: Case report and literature review显示文摘Giant esophageal and hypopharyngeal polyps are benign tumors rarely encountered in clinical practice.In most cases,they are completely asymptomatic;however,despite the rarity of these tumors,interest in giant esophageal polyps derives from their degree of growth(characterized by slow growth into the esophageal lumen)and their mobility.In fact,if regurgitation occurs,they can ascend into the oral cavity and be aspirated into the airways,with potentially lethal consequences.The removal of these giant polyps is recommended.An adequate preoperative evaluation to identify the correct origin of the stalk is mandatory for a successful endoscopic or surgical treatment.A 60-year-old man was admitted to our hospital for anemia.The patient underwent gastroscopy,contrast computed tomography and endoscopic ultrasound.At the conclusion of the procedure,during the extraction of the echoendoscope,the patient began retching and regurgitated the polyp,without experiencing respiratory distress.The patient underwent a left cervicotomy and polyp dissection via a pharyngotomy. | Giovanni Pallabazzer Stefano Santi Solito Biagio Simone D'Imporzano | 2013 | World Journal of Gastroenterology2013，19，35： | 3 |
| 5 | On the contrast in visual cryptography schemes显示文摘 | BLUNDO C De SANTIS A STINSON D R | 1999 | Journal of Cryptology1999，，12： | 1 |
| 6 | Finite state automata as conceptual model for services显示文摘 | Berardi D Rosa F D Santis L D | 2004 | Integrated De-sign and Process Technology2004，8，2： | 1 |
| 7 | Visual cryptography for general access structures显示文摘 | ATENIES G CARLO B SANTIS A D | 1996 | Inf Comput1996，129，2： | 1 |
| 8 | Design of self-healing key distribution schemes 显示文摘 | BLUNDO C D' ARCO P SANTIS A | 2004 | Designs Codes and Cryptography2004，32，123： | 1 |
| 9 | The critical transmitting range for connectivity in sparse wireless ad hoc networks显示文摘 | SANTI P BLOUGH D M | 2003 | IEEE Transactions on Mobile Computing2003，2，1： | 1 |
| 10 | Security of Public Key Cryptosystems based on Chebyshev Polynomials 显示文摘 | Pina Bergamo Paolo D' Aroc Alfredo De Santis etc | 2005 | IEEE Transac- tions on Circuits and Systems2005，752，7： | 1 |
| 11 | Construction of a homodimeric dihydrofolate reductase - thymidylate synthase bifunctional en- zyme 显示文摘 | Trujillo M Duncan R Santi D | 1997 | Protein Eng1997，10，5： | 1 |
| 12 | Perfectly secure key distribution for dynamic conferences显示文摘 | Blundo C Santis A D Herzberg A | 1998 | Information and Computation1998，146，1： | 1 |
| 13 | Novel Brcnsted acidic deep eutectic solvent as reaction media for esterification of carboxylic acid with alcohols 显示文摘 | SANTI V D CARDELLINI F BRINCHI L | 2012 | Tetra- hedron Lett2012，53，38： | 1 |
| 14 | MIMO distributed imaging ofrotating targets for improved 2-D resolution 显示文摘 | Pastina D Santi F Bucciarelli M | 2014 | IEEE Geoscience and Remote Sensing Letters2014，12，1： | 1 |
| 15 | A spherical cap harmonic analysis model of the crustal magnetic anomaly field in Europe observed by Magsat显示文摘 | De Santis A Kerridge D Barraclough D | 1989 | Geomagnetism and Palaeomagnetism1989，261，： | 1 |
| 16 | On the contrast in visual cryptography schemes显示文摘 | BOUNDO C SANTIS A D STINSON D R | 1999 | J Crypto1999，12，4： | 1 |
| 17 | Levosimendan pre-treat- ment improves outcomes in patients undergoing coronary artery bypass graft surgery显示文摘 | Tritapepe L De Santis V Vitale D | 2009 | Br J Anaesth2009，102，2： | 1 |
| 18 | Growing backwards: an inverted role for the shrimp ortholog of vertebrate myostatin and GDFll 显示文摘 | DE SANTIS C WADE N M Jerry D R | 2011 | The Journal of Experimental Biology2011，214，16： | 1 |
| 19 | Growing backwards: an inverted role for the shrimp ortholog of vertebrate myostatin and GDFll 显示文摘 | De Santis C Wade N M Jerry D R | 2011 | J Exp Biol2011，214，16： | 1 |
| 20 | Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic host 显示文摘 | Liu L Santi D V | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
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