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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 3 | Oxytocin infusion during second stage of labor in primiparous women using epidural analgesia: a randomized double blind placebo-controlled trial显示文摘 | Spiby H Gilbert L | 1989 | Br Med J1989，299，6713： | 1 |
| 4 | The surgical treatment of type II diabetes mellitus:changes in HOMA Insulin resistance in the first year following laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic adjustable gastric banding (LAGB)显示文摘 | Ballantyne G H Wasielewski A Saunders J K | 2009 | Obesity Surgery2009，19，9： | 1 |
| 5 | Charge separation during the fragmentation of rime and frost 显示文摘 | Saunders C P R Hickson H Malone M D Richtofen J V | 1993 | Atmospheric Research1993，83，： | 1 |
| 6 | Nature of the spermatogenic arrest in Dazl -/-mice显示文摘 | SCHRANS - STASSEN B H SAUNDERS P T COOKE H J | 2001 | Biol Re- prod2001，65，3： | 1 |
| 7 | Identification of phosphate-reactive sites of hydrous alumina from proton consumption during phosphate adsorption at constant pH values显示文摘 | Rajan S S S Perott K w Saunders W M H 1974 | 1974 | J Soil Sci1974，25，： | 1 |
| 8 | Assessing pho tochemieal ozone ormation in the Pearl River Delta with a photochemical trajectory model显示文摘 | CHENG H R GUO H SAUNDERS S M | 2010 | Atmospheric Environment2010，44，34： | 1 |
| 9 | Human polymorphism at microRNAs and microRNA target sites显示文摘 | Saunders MA Liang H Li WH | | 0，，： | 1 |
| 10 | Expression of the Wilms' tumor gene (wt1) in human Leukemias显示文摘 | Miwa H Beran M Saunder GF | 1992 | Leukemia1992，6，： | 1 |
| 11 | Forming of tailor-welded blanks显示文摘 | Saunders F I Wagoner R H | 1996 | Metallurgical and Materials Transactions A (USA)1996，27，9： | 1 |
| 12 | Road and Bridge Construction Across Gypsum Karst in England 显示文摘 | Anthony H Cooper Jonathan M Saunders | 2002 | Engineering Geology2002，65，： | 1 |
| 13 | Forming of tailor-welded blanks显示文摘 | Saunders F I Wagoner R H | 1996 | Metallurgical and Materials Transactions A1996，27，9： | 1 |
| 14 | Intrauterine adhesions after manual vacuum aspiration for early pregnancy failure 显示文摘 | Dalton V K Saunders N A Harris L H | 2006 | Feail Steril2006，85，6： | 1 |
| 15 | Distribution of phosphorous in profiles and particle-size fractions of some Scottish soils显示文摘 | WILLIAMS E G SAUNDERS W M H | 1956 | Journal of Soil Science1956，7，： | 1 |
| 16 | The Determinants of BankInterest Margins: Theory and Empirical Evidence显示文摘 | H(〕TS Y SAUNDERS A | 1981 | Journal of Financial and Quantitative Analysis1981，16，4： | 1 |
| 17 | Open-channel estimation of denitrification显示文摘 | McCutchan J H Saunders J F Pribyl A L | 2003 | Limnology and Oceanography: Methods2003，1，： | 1 |
| 18 | Metal concentrations in scleractionean corals determined by instrumental neutron activation analysis and atomic absorption spectro-metry显示文摘 | Saunders M G Cabrera M E M Peraza E F H | 1997 | Journal of Radioanalytical and Nuclear Chemistry1997，219，： | 1 |
| 19 | A model of structure optimization for a functionally graded material显示文摘 | Markworth A J Saunders J H | 1995 | Mater Lett1995，17，22： | 1 |
| 20 | A note on a sufficient-decrease criterion for a nonderivative steplength procedure 显示文摘 | Gill E P Murry Saunders W Wright H M | 1982 | Mathematical Programming1982，23，： | 1 |
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