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	题名	作者	年代	出处	被引量
1	Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs.	Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth	2007	World Journal of Gastroenterology2007，13，48：	4
2	Occurrence of Bursaphelenchus species in declining Pinus sylvestris in a dry Alpine valley in Switzerland显示文摘	POLOMSKI J SCH魻NFELD U BRAASCH H	2005	Forest Pathology2005，35，：	1
3	Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors显示文摘	Siegsmund M Brinkmann U Scháffeler E Weirich G Schwab M Eichelbaum M	2002	J Am Soc Nephrol2002，13，7：	1
4	Use of Saccharomyces cerevisiae cells immobilized on orange peel as biocatalyst for alcoholic fermentation显示文摘	Sch B S Coleraine B T	2007	Bioresource Technology2007，98，4：	1
5	Novel xylose dehydrogenase in the ha- lo-philic archaeon Haloarcula marismortut显示文摘	Johnsen U Sch?nheit P	2004	J Bacteriol2004，186，：	1
6	Using the international 10-20 EEG system for positioning of transcranial magnetic stimulation 显示文摘	HERWIG U SATRAPI P SCH? NFELDT-LECUONA C	2003	Brain Topogr2003，16，2：	1
7	The CD40/CD154 receptor/ligand dyad显示文摘	Sch(o)nbeck U Libby P	2001	Cell Mol Life Sci2001，58，1：	1
8	Role of adipose tissue as an inflammatory or- gan in human diseases 显示文摘	SCHAFFLER A MULLER-LADNER U SCH()LMERICH J BOCHLER C	2005	Endocr Rev2005，27，5：	1
9	MRD at the end of induction therapy in childhoodacute lymphoblastic leukemia:outcome predictionstrongly depends on the therapeutic regimen显示文摘	ZUR STADT U HARMS DO SCH TER S	2001	Leukemia2001，15，2：	1
10	Processes involved in formation and emission of methane in rice paddies显示文摘	Sch(U)tz H Seiler W Conrad R	1998	Biogeochemistry1998，7，1：	1
11	The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca~(2+) depletion显示文摘	Copanaki E Sch(u\|¨)rmann T Eckert A	2007	Biochim Biophys Acta2007，1773，2：	1
12	Mandibular setback for surgical correction of mandibular hyperplasia-does it provoke sleep-related breathing disorders显示文摘	Hochban W Schü rmann R Brandenburg U		0，，5：	1
13	Cad- herins and the rum our progression:is it all in a switch 显示文摘	Cavalaro U Sch Affh Auser B Ch Ristofori G	2002	Cancer Lett2002，176，：	1
14	Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients显示文摘	Burghaus L Schütz U Krempel U	2000	Brain Res Mol Brain Res2000，76，2：	1
15	Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis显示文摘	Shimizu K Sch(o)nbeck U Mach F	2000	J Immunol2000，165，6：	1
16	Properties of wheat straw partieleboards bonded with different types of resin显示文摘	Boquillon N Elbez G R Sch Nfeld U	2004	Journal of Wood Science2004，50，50：	1
17	Delphi common rail system with direct acting injector显示文摘	SCH(O)PPEID Z(U)LCH D I S HARDY M	2008	MTZ worldwide2008，69，10：	1
18	Percutaneous aortic valve replacement:overview and suggestions for anesthestic management 显示文摘	Heinze H Sier H Sch? fer U	2010	J Clin Anesth2010，22，5：	1
19	Valve-in-valve transcatheter aortic valve implantation for degenerated bioprosthetic heart valves显示文摘	Eggebrecht H Schǎfer U Treede H		0，，11：	1
20	The Ailao Shan/Red River metamorphic belt: Tertiary left-lateral shear between Indochina and South China显示文摘	Tapponnier P Lacassin R Leloup P H Sch~irer U Zhong Dalai Wu Haiwei Liu Xiaohan Ji Shaocheng Zhang Lianshang Zhong Jiayou	1990	Nature1990，343，6257：	1

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