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| 1 | 反流性食管炎中埃索美拉唑比奥美拉唑更能促进病变愈合和症状缓解显示文摘 | Kahrilas PJ Falk GW Johnson DA Schmitt C Collins DW Whipple J D’Amino D Hamelin B Joelsson B 钟捷 | 2002 | 中华消化杂志2002，22，11： | 19 |
| 2 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 3 | Examining the effect of adverse geological conditions on jamming of a single shielded TBM in Uluabat tunnel using numerical modeling显示文摘Severe shield jamming events have been reported during excavation of Uluabat tunnel through adverse geological conditions, which resulted in several stoppages at advancing a single shielded tunnel boring machine(TBM). To study the jamming mechanism, three-dimensional(3D) simulation of the machine and surrounding ground was implemented using the finite difference code FLAC3D. Numerical analyses were performed for three sections along the tunnel with a higher risk for entrapment due to the combination of overburden and geological conditions. The computational results including longitudinal displacement contours and ground pressure profiles around the shield allow a better understanding of ground behavior within the excavation. Furthermore, they allow realistically assessing the impact of adverse geological conditions on shield jamming. The calculated thrust forces, which are required to move the machine forward, are in good agreement with field observations and measurements. It also proves that the numerical analysis can effectively be used for evaluating the effect of adverse geological environment on TBM entrapments and can be applied to prediction of loads on the shield and preestimating of the required thrust force during excavation through adverse ground conditions. | Rohola Hasanpour Jürgen Schmitt Yilmaz Ozcelik Jamal Rostami | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，6： | 8 |
| 4 | SolEmuls ? —novel technology for the formulation of i.v. emulsions with poorly soluble drugs显示文摘 | R.H Müller S Schmidt I Buttle A Akkar J Schmitt S Br?mer | 2003 | International Journal of Pharmaceutics2003，，2： | 3 |
| 5 | Immunocytochemical detection of somatostatin receptors sst1, sst2A, sst2B, and sst3 in paraffin-embedded breast cancer tissue using subtypespecific antibodies显示文摘 | Schulz S Schulz S Schmitt J | 1998 | Clin Cancer Res1998，4，： | 2 |
| 6 | Properties and struc- tures of tin borophosphate glasses显示文摘 | Lira J W Schmitt M L Brow R K | 2010 | Journal of Non-Crystal- line Solids2010，356，： | 1 |
| 7 | Identification and characterization of the bovine herpesvirus 1 UL7 gene and gene product which are not essential for virus replication in cell culture 显示文摘 | Schmitt J Keil G M | 1996 | J Virol1996，70，2： | 1 |
| 8 | Simple Photon Diffusion Analysis of the Effects of Multiple Scattering on Pluse Oximetry 显示文摘 | Schmitt J M | 1991 | IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING1991，38，12： | 1 |
| 9 | Long-term follow-up of pseud-oexfoliation and the development of elevated intraocular pres-sure显示文摘 | Henry J C Krupin T Schmitt M | 1987 | Ophthalmology1987，94，： | 1 |
| 10 | Reconstructed anterior cru-ciate ligaments using patellar tendon ligament grafts: diagnostic value of contrast-enhanced MRI in a 2-year follow-up regimen显示文摘 | Vogl TJ Schmitt J Lubrich J | 2001 | Eur Radiol2001，11，： | 1 |
| 11 | On the G1 continuity of piecewise Bézier surface: a review with new results显示文摘 | Wen-Hui Du and Francis J M Schmitt | 1990 | Computer-Aided Design1990，22，9： | 1 |
| 12 | Characterization of Pore Systems in Seal Rocks Using Nitrogen Gas Adsorption Combined with Mercury Injection Capillary Pressure Techniques 显示文摘 | Schmitt M Fernandes C P da Cunha Neto J A B | 2013 | Marine and Petroleum Geology2013，39，1： | 1 |
| 13 | Multiplication of human immunodeficiency virus in primary cultures of human kupffer cells-possible role of liver macrophage infection in the physiopathology of AIDS显示文摘 | Steffan A M Gendranlt J L | 1990 | Res Virol1990，141，： | 1 |
| 14 | Multi - slice spiral CT of the coronary arteries: clear vascular imaging using standard software显示文摘 | Frohner S Brunn J | 2001 | Rontgenpraxis2001，54，4： | 1 |
| 15 | Import of mitochondrial transcription factor A (TFAM) into rat liver mitochondria stimulates transcription of mitochondrial DNA 显示文摘 | GARSTKA H L SCHMITT W E SCHULTZ J | 2003 | Nucleic Acids Res2003，31，17： | 1 |
| 16 | Optimal probe geometry for nearinfrared spectroscopy of biological tissue显示文摘 | KUMAR G SCHMITT J M | 1997 | Applied Optics1997，36，10： | 1 |
| 17 | DNA methyl-ation asa biomarker in breast cancer显示文摘 | Martens J W Margossian A L Schmitt M | 2009 | Future Oncol2009，5，8： | 1 |
| 18 | The viral killer system in yeast:from molecular biology to application显示文摘 | SCHMITT M J BREINIG F | 2002 | FEMS Microbiol Rav2002，，26： | 1 |
| 19 | Infinite-horizonmodels for inventory control under yield uncertaintyand disruptions 显示文摘 | SCHMITT A J SNYDER L V | 2012 | Computers & OperationsResearch2012，39，4： | 1 |
| 20 | Combined topical therapy of psoriasis: Position of calcitriol and vitamin D analogs显示文摘 | Schmitt J Meurer M | 2006 | Hautarzt2006，57，： | 1 |
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