|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 内侧固定平台单髁置换术后的冠状面下肢力线是翻修的影响因素显示文摘膝关节单髁置换术(unicompartmental knee arthroplasty,UKA)后患者冠状面的下肢力线被认为是影响手术长期疗效的一个重要因素,但关于最佳的UKA术后下肢力线还没有形成明确共识。一些研究主张术后下肢力线应保持在中立位,而另一些研究认为即使术后下肢力线存在10°的内翻也可获得良好的临床效果。 | Sean E Slaven John P Cody Robert A Sershon Henry Ho Robert H Hopper Jr Kevin B Fricka 李亚坤(整理) 张民(整理) | 2020 | 实用骨科杂志2020，26，12： | 15 |
| 2 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 3 | Catatonia:Our current understanding of its diagnosis, treatment and pathophysiology显示文摘Catatonia is a psychomotor syndrome that has been reported to occur in more than 10% of patients with acute psychiatric illnesses. Two subtypes of the syndrome have been identified. Catatonia of the retarded type is characterized by immobility, mutism, staring, rigidity, and a host of other clinical signs. Excited catatonia is a less common presentation in which patients develop prolonged periods of psychomotor agitation. Once thought to be a subtype of schizophrenia, catatonia is now recognized to occur with a broad spectrum of medical and psychiatric illnesses, particularly affective disorders. In many cases, the catatonia must be treated before any underlying conditions can be accurately diagnosed. Most patients with the syndrome respond rapidly to low-dose benzodiazepines, but electroconvulsive therapy is occasionally required. Patients with longstanding catatonia or a diagnosis of schizophrenia may be less likely to respond. The pathobiology of catatonia is poorly understood, although abnormalities in gamma-aminobutyric acid and glutamate signaling have been suggested as causative factors. Because catatonia is common, highly treatable, and associated with significant morbidity and mortality if left untreated, physicians should maintain a high level of suspicion for this complex clinical syndrome. Since 1989, we have systematically assessed patients presenting to our psychiatry service with signs of retarded catatonia. In this paper, we present a review of the current literature on catatonia along with findings from the 220 cases we have assessed and treated. | Sean A Rasmussen Michael F Mazurek Patricia I Rosebush | 2016 | World Journal of Psychiatry2016，6，4： | 7 |
| 4 | The spectrum of neuromyelitis optica显示文摘 | Dean M Wingerchuk Vanda A Lennon Claudia F Lucchinetti Sean J Pittock Brian G Weinshenker | 2007 | Lancet Neurology2007，，9： | 3 |
| 5 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 6 | Spinal arteriovenous shunts presenting before 2 years of age : analysis of 13 cases 显示文摘 | Sean C Hortensia A Georges R | 2006 | Childs Nerv Syst2006，22，： | 1 |
| 7 | A highly specific L-galactose-1-phosphate phosphatase on the path to ascorbate biosynthesis显示文摘 | WILLIAM A LAING SEAN B | 2004 | PNAS2004，48，16： | 1 |
| 8 | Different regulation of the fibroblast growth factor(FGF)family by a macroglobulin:evidence for selec tive modulation of FGF-2-induced angiogenesis Blood显示文摘 | Lain R A Sean M W Smitha M | 2001 | Ameriean Congress of Cardiology Adant2001，97，11： | 1 |
| 9 | Magnesium reduces free radicals in a in vivo coronary occlusion reperfusion model显示文摘 | Lawrence A Steven C Sean M | 2008 | J Am Coil Cardiol2008，32，2： | 1 |
| 10 | Magnesium reduceds free radicals in a in vivo caranary occlasion reperfusion model 显示文摘 | Lawrence A Steven C Sean | 1998 | Am Coll Cardiol1998，32，2： | 1 |
| 11 | Talar neck fractures:results and outcomes显示文摘 | Heather A Sean E David P | 2004 | J Bone Joint Surg Am2004，86，8： | 1 |
| 12 | Principles of good practice for budget impact analysis : report of the ISPOR task force on good research practices-budget impact analysis 显示文摘 | JOSEPHINE A M SEAN D S LIEVEN A | 2007 | Val- ue Health2007，10，5： | 1 |
| 13 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | 2004 (9451)2004，，9451： | 1 |
| 14 | Real-time path planning in dynamic virtual environment using multiagent navigation graphs显示文摘 | A vneesh S Erik A Sean C | 2008 | IEEE Trans on Visualization and Computer Graphics2008，14，3： | 1 |
| 15 | Application of fiber reinforced polymer overlays to extend steel fatigue life显示文摘 | Sean C Jones Scott A Civjan P E | 2003 | Journal of Composite for Construction2003，7，4： | 1 |
| 16 | Polymeric Microelectromechanical Systems显示文摘 | Steven A S Sean M F Shize Q | 2000 | Analytical Chemistry2000，72，： | 1 |
| 17 | Molecular regulation of cardiac hypertrophy 显示文摘 | Sean P Barry Sean M Davidson Paul A Townsend | 2008 | Intern Biochem Cell Biol2008，40，10： | 1 |
| 18 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | The Lancet2004，，9451： | 1 |
| 19 | Real-time path planning in dynamic virtual environment using multi-agent navigation graphs 显示文摘 | Avneesh S Erik A Sean C | 2008 | IEEE Transon Visualization and Computer Graphics2008，14，3： | 1 |
| 20 | Cerebral CT angiography显示文摘 | Sean O Casey MD Ronald A | 1996 | Radiology1996，198，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员