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| 1 | Experimental evidence on the immunopathogenesis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis(PBC)is a chronic cholestatic liver disease for which an autoimmune pathogenesis is supported by clinical and experimental data,including the presence of autoantibodies and autoreactive T cells.The etiology remains to be determined,yet data suggest that both a susceptible genetic background and unknown environmental factors determine disease onset.Multiple infectious and chemical candidates have been proposed to trigger the disease in a genetically susceptible host,mostly by molecular mimicry.Most recently,several murine models have been reported,including genetically determined models as well as models induced by immunization with xenobiotics and bacteria. | Carlo Selmi Francesca Meda Anaid Kasangian Pietro Invernizzi Zhigang Tian Zhexiong Lian Mauro Podda M Eric Gershwin | 2010 | Cellular & Molecular Immunology2010，7，1： | 14 |
| 2 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 3 | Genetics and geoepidemiology of primary biliary cirrhosis: following the fovtprints to disease etiology显示文摘 | SELMI C ZNVERNIZZI P ZNIN M | 2005 | Semin Liver Dis2005，25，3： | 1 |
| 4 | Spermatozoa of two Eledone species (Cephalopoda,Octopoda)显示文摘 | SELMI M G | | 0，，28： | 1 |
| 5 | Short communication effect of mean stress on fatigue behavior of GFRP pultruded rod composites 显示文摘 | Abd Allah M H Enayat MAbdin Selmy A I | 1997 | Composite:Part1997，28，： | 1 |
| 6 | Liver abnormalities in connective tissue diseases显示文摘 | De Santis M Crotti C Selmi C | | 0，，04： | 1 |
| 7 | Systemic sepsis exacerbates mild post traumatic brain injury in the rat显示文摘 | Venturi L Miranda M Selmi V | 2009 | J Neurotrauma2009，26，9： | 1 |
| 8 | Chemical restraint of peccaries with tiletamine/zolazepam and xylazine or tiletamine/zolazepam and butorphanol显示文摘 | SELMI A L MENDES G M FIGUEIREDO J P | 2003 | Vet Anaesth Analg2003，30，1： | 1 |
| 9 | Atrial fibrillationfollowing coronary artery bypass grafting:predictors and mid-term outcome显示文摘 | Ben Ahmed H Chelli M Selmi K | 2012 | Tunis Med2012，90，12： | 1 |
| 10 | Tumor vaccination using mes-senger RNA:prospects of a future therapy 显示文摘 | Kreiter S Diken M Selmi A | 2011 | Curr Opin Immunol2011，23，3： | 1 |
| 11 | Primary biliary cirrhosis in monozygotic and dizygotic twins:genetics,epigeneties,and environment显示文摘 | Selmi C Mayo M J Bach N Ishibashi H Invernizzi P Gish R G | 2004 | Gastroenterology2004，127，： | 1 |
| 12 | Serum inflammatory eyto- kines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis 显示文摘 | Barak V Selmi C Schlesinger M | 2009 | J Autoimmun2009，33，34： | 1 |
| 13 | Use of a combination of propofol and fentanyl, alfentanil,or sufentanil for total intravenous anesthesia in cats显示文摘 | Mendes G M Selmi A L | 2003 | J Am Vet Med Assoc2003，223，11： | 1 |
| 14 | Role of intra-operative ulatrasound-guided reduction of na- sal bone fracture in patient satisfaction and patient nasal profile显示文摘 | ABU-SAMRA M SELMI G MANSY H | 2011 | Eur Arch Otorhinolaryngol2011，268，： | 1 |
| 15 | Update on primary biliary cir- rhosis 显示文摘 | Invemizzi P Selmi C Gershwin M E | 2010 | Digestive and Liver Disease2010，42，6： | 1 |
| 16 | Factors affecting colony size and re- productive success of little egret in the Sfax Salina, Tuni- sia显示文摘 | Chokri M A Selmi S | 2011 | Waterbirds2011，34，2： | 1 |
| 17 | Serum inflammatory cy-tokines,complement components,and soluble interleukin 2 recep-tor in primary biliary cirrhosis显示文摘 | Barak V Selmi C Schlesinger M | 2009 | J Autoimmun2009，33，34： | 1 |
| 18 | Liver abnormalities in connective tissue diseases 显示文摘 | De Santis M Crotti C Selmi C | 2013 | Best Pract Res Clin Gastroenterol2013，27，4： | 1 |
| 19 | A bifurcation study of viscous flow through a rotating curvedpipe显示文摘 | SELMI M NANDAJYNAR K FINLAY W H | 1994 | J Fluid Meeh1994，262，： | 1 |
| 20 | Genetics and geoepidemiology of primary biliary cirrhosis: following the footprints to disease etiology 显示文摘 | Selmi C Invernizzi P Zuin M | 2005 | Semin Liver Dis2005，25，3： | 1 |
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