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| 1 | Return to sport following tibial plateau fractures: A systematic review显示文摘AIM To systemically review all studies reporting return to sport following tibial plateau fracture, in order to provide information on return rates and times to sport, and to assess variations in sporting outcome for different treatment methods.METHODS A systematic search of CINAHAL, Cochrane, EMBASE, Google Scholar, MEDLINE, PEDro, Scopus, SPORTDiscus and Web of Science was performed in January 2017 using the keywords 'tibial', 'plateau', 'fractures', 'knee', 'athletes', 'sports', 'non-operative', 'conservative', 'operative', 'return to sport'. All studies which recorded return rates and times to sport following tibial plateau fractures were included. RESULTS Twenty-seven studies were included: 1 was a randomised controlled trial, 7 were prospective cohort studies, 16 were retrospective cohort studies, 3 were case series. One study reported on the outcome of conservative management(n = 3); 27 reported on the outcome of surgical management(n = 917). Nine studies reported on Open Reduction Internal Fixation(ORIF)(n = 193), 11 on Arthroscopic-Assisted Reduction Internal Fixation(ARIF)(n = 253) and 7 on Frame-Assisted Fixation(FRAME)(n = 262). All studies recorded 'return to sport'rates. Only one study recorded a 'return to sport' time. The return rate to sport for the total cohort was 70%. For the conservatively-managed fractures, the return rate was 100%. For the surgically-managed fractures, the return rate was 70%. For fractures managed with ORIF, the return rate was 60%. For fractures managed with ARIF, the return rate was 83%. For fractures managed with FRAME was 52%. The return rate for ARIF was found to be significantly greater than that for ORIF(OR 3.22, 95%CI: 2.09-4.97, P < 0.001) and for FRAME(OR 4.33, 95%CI: 2.89-6.50, P < 0.001). No difference was found between the return rates for ORIF and FRAME(OR 1.35, 95%CI: 0.92-1.96, P = 0.122). The recorded return time was 6.9 mo(median), from a study reporting on ORIF.CONCLUSION Return rates to sport for tibial plateau fractures remain limited compared to other fractures. ARIF provides the best return rates. There is limited data regarding return times to sport. Further research is required to determine return times to sport, and to improve return rates to sport, through treatment and rehabilitation optimisation. | Greg A J Robertson Seng J Wong Alexander M Wood | 2017 | World Journal of Orthopedics2017，8，7： | 10 |
| 2 | Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer:The role of inflammation显示文摘Chemotherapy-induced diarrhea(CID)is a common and often severe side effect experienced by colorectal cancer(CRC)patients during their treatment.As chemotherapy regimens evolve to include more efficacious agents,CID is increasingly becoming a major cause of dose limiting toxicity and merits further investigation.Inflammation is a key factor behind gastrointestinal(GI)toxicity of chemotherapy.Different chemotherapeutic agents activate a diverse range of pro-inflammatory pathways culminating in distinct histopathological changes in the small intestine and colonic mucosa.Here we review the current understanding of the mechanisms behind GI toxicity and the mucositis associated with systemic treatment of CRC.Insights into the inflammatory response activated during this process gained from various models of GI toxicity are discussed.The inflammatory processes contributing to the GI toxicity of chemotherapeutic agents are increasingly being recognised as having an important role in the development of anti-tumor immunity,thus conferring added benefit against tumor recurrence and improving patient survival.We review the basic mechanisms involved in the promotion of immunogenic cell death and its relevance in the treatment of colorectal cancer.Finally,the impact of CID on patient outcomes and therapeutic strategies to prevent or minimise the effect of GI toxicity and mucositis are discussed. | Chun Seng Lee Elizabeth J Ryan Glen A Doherty | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 3 | Fundus changes in pregnancy induced hypertension显示文摘AIM: To determine the prevalence of retinal changes in pregnancy induced hypertension (PIH) and any association between the retinal changes and blood pressure, proteinuria, and severity of the disease. METHODS: All the patients admitted with diagnosis of PIH were included in this study. Age, race, gravida, gestation period, blood pressure, and proteinuria were noted from the case records. After taking history for any eye symptoms, fundus examination was done after dilating the pupils with direct ophthalmoscope in the ward itself. All the findings were noted on a data sheet, and were analyzed using SPSS programme. RESULTS: A total of 78 patients of PIH were examined. Majority (75.6%) were Malays. The mean age of patients was 30.2 years (range 21-45 years). The gestation period ranged from 25 weeks to 41 weeks; 34 (43.5%) were primi gravida. Thirty (38.4%) patients had mild preeclampsia, 46 (59%) had severe preeclampsia and 2(2.5%) had eclampsia. Retinal changes (hypertensive retinopathy) were noted in 46 (59%) patients --- grade I in 41 (52.6%) and grade II in 5 (6.4%). Haemorrhages or exudates or retinal detachment were not seen in any patient. There was statistically significant positive association of retinal changes and blood pressure (P =0.001), proteinuria (P =0.018) and severity of the PIH (P =0.024). CONCLUSION: Retinal changes (grade I and II hypertensive retinopathy) were seen in 59% of patients with PIH and they were significantly associated with blood pressure, proteinuria and severity of the disease. Fundus examination helps in assessing the severity of PIH. | Sagili Chandrasekhara Reddy Sivalingam Nalliah Sheila Rani a/pKovil George Tham Seng Who | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 3 |
| 4 | HLA class Ⅱ alleles in patients with alopecia areata显示文摘 | Akar A Orkunoglu E Sengül A | 2002 | Eur J Dermatol2002，12，： | 1 |
| 5 | Nonlinear Optical Properties of Porphyrins 显示文摘 | Senge M O Fazekas M Notaras E G A | 2007 | Adv Mater2007，19，19： | 1 |
| 6 | Plate tectonics and orogemc research after 25 years:A Tethyan perspective显示文摘 | Sengǎr A M C | 1990 | Earth-Science Reviews1990，27，12： | 1 |
| 7 | Retroposition in a family of carcinoma-associated antigen genes 显示文摘 | Liunebnach A J Seng BA WUS | 1993 | Mol Cell Biol1993，13，3： | 1 |
| 8 | Evolving fuzzypattern trees for binary classification on data streams显示文摘 | Shaker A Senge R Hllermeier E | 2012 | Inforamtion Sciences2012，19，2： | 1 |
| 9 | Comparison of hmg term clinical outcomes, event free survival rates of patients undergoing enhanced external counterpulsation for coronary artery disease in the United States and Turkey 显示文摘 | Soran O Ikizler C Seng ii I A | 2012 | Turk Kardiyol Dem Ars2012，40，4： | 1 |
| 10 | A review of bio-metric technology along with trends and prospects 显示文摘 | UNAR J A SENG W C ABBASI A | 2014 | Pattern Recognition2014，47，8： | 1 |
| 11 | Cytotoxicity evaluation of dentin bonding agents by dentin barrier test on 3-dimensional pulp cells显示文摘 | Sengün A Yaln M lker HE | 2011 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2011，112，3： | 1 |
| 12 | DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma显示文摘 | Seng T J Currey N Cooper W A | 2008 | Br J Cancer2008，99，2： | 1 |
| 13 | Performance com- parison of constructed wetlands with gravel- and rice husk-based media for phenol and nitrogen removal 显示文摘 | Tee H C Seng C E Noor A M | 2009 | Sci Total Environ2009，407，11： | 1 |
| 14 | Performance comparisonof constructed wetlands with gravel-and rice husk-based media forphenol and nitrogen removal显示文摘 | TEE H C SENG C E NOOR A M ef al | 2009 | Science of the Total Environment2009，407，11： | 1 |
| 15 | Low-temperature chromium (Ⅵ) biotransformation in soil with varying electron acceptors显示文摘 | T seng J K Bielefeldt A R | 2002 | Environ Qual2002，31，5： | 1 |
| 16 | Abdominal cocoon: A report of two cases显示文摘 | Seng LK Mahadaven M Musa A | 1993 | Br J Surg1993，80，9： | 1 |
| 17 | Aerospace propulsion and power materials and structures research at NASA Glenn re- search center 显示文摘 | MISRA A K LESLIE A SENG G | 2013 | Journal of Aerospace Engineering2013，26，2： | 1 |
| 18 | HLA class Ⅱ alleles in patients with alopecia areata显示文摘 | Akar A Orkunoglu E Sengül A | 2002 | Ear J Dermatol2002，12，： | 1 |
| 19 | Osteomyelitis of sternum and rib after breast prosthesis implantation:a rare or underestimated infection显示文摘 | Seng P Alliez A Honnorat E | 2014 | IDCases2014，2，1： | 1 |
| 20 | The cimmeride orogenic system and the tectonics of Eurasia显示文摘 | Sengor A M C | 1984 | Geological society of America Special Paper1984，195，： | 1 |
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