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| 1 | CYP2D6的多态性与文拉法辛的临床效应显示文摘 | Shams ME Arneth B Hiemke C 王小艳 | 2006 | 中国处方药2006，5，10： | 12 |
| 2 | Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma显示文摘 | Li G Sham J Yang J Su C Xue H Chua D Sun L Zhang Q Cui Z Wu M Qian Q | 2005 | 第二军医大学学报2005，26，11： | 9 |
| 3 | Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders显示文摘Autism and autism spectrum disorders(ASD) refer to a range of conditions characterized by impaired social and communication skills and repetitive behaviors caused by different combinations of genetic and environmental influences. Although the pathophysiology underlying ASD is still unclear, recent evidence suggests that immune dysregulation and neuroinflammation play a role in the etiology of ASD. In particular, there is direct evidence supporting a role for maternal immune activation during prenatal life in neurodevelopmental conditions. Currently, the available options of behavioral therapies and pharmacological and supportive nutritional treatments in ASD are only symptomatic. Given the disturbing rise in the incidence of ASD, and the fact that there is no effective pharmacological therapy for ASD, there is an urgent need for new therapeutic options. Mesenchymal stem cells(MSCs) possess immunomodulatory properties that make them relevant to several diseases associated with inflammation and tissue damage. The paracrine regenerative mechanisms of MSCs are also suggested to be therapeutically beneficial for ASD.Thus the underlying pathology in ASD, including immune system dysregulation and inflammation, represent potential targets for MSC therapy. This review willfocus on immune dysfunction in the pathogenesis of ASD and will further discuss the therapeutic potential for MSCs in mediating ASD-related immunological disorders. | Qiang Liu Mo-Xian Chen Lin Sun Chloe U Wallis Jian-Song Zhou Li-Juan Ao Qi Li Pak C Sham | 2019 | World Journal of Stem Cells2019，11，2： | 5 |
| 4 | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings显示文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. | LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 5 | Prokineticin-1 (Prok-1) works coordinately with glial cell line derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells显示文摘 | Ngan E S Shum C K Poon H C Sham M H Garcia-Barcelo M M Lui V C | 2008 | Biochim Biophys Acta2008，1783，： | 1 |
| 6 | Treatment re- suits of sinonasal inverted papilloma: an 18-year study 显示文摘 | Sham C L Woo J K van Hasselt C A | 2009 | Am J Rhinol Allergy2009，23，2： | 1 |
| 7 | In-situ polymerization of n-bu-tyl acrylate in poly(vinyl chloride)显示文摘 | C K Sham | 1984 | Polymer1984，25，2： | 1 |
| 8 | Hyperphosphorylated neu-rofilament NF-H is a serum biomarker of axonal injury显示文摘 | Sham G Yang C Ellis R | 2005 | Biochem Biophys Res Commum2005，336，： | 1 |
| 9 | Two-stage genome-wide as- sociation study identifies variants in CAMSAPI LI as susceptibility loci for epilepsy in Chinese 显示文摘 | Guo Y L Baum L W Sham P C | 2012 | Hum Mol Genct2012，21，5： | 1 |
| 10 | Impact of Caregiving on Health and Quality of Life : A Comparative Popu- lation-based Study of Caregivers for Elderly Persons and Noncaregivers 显示文摘 | Ho S C Chan A Woo J Chong P and Sham A | 2009 | Journals of Gerontology Series A: Biologi- cal Sciences and Medical Sciences2009，64，： | 1 |
| 11 | Threshold Contrast Ratio and Masking Ability of Porcelain Veneers with High-density Alumina Cores显示文摘 | Chu F C Sham A S Luk H W | 2004 | Int J Prosthodont2004，17，： | 1 |
| 12 | Texture of vacuum microwave dehydrated apple chips as affected by calcium pretreatment vacuum level and apple variety 显示文摘 | Sham P W Y Scaman C H Durance T D | 2001 | Food Science2001，66，9： | 1 |
| 13 | Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient antitumor activity in immunodeficient and immunocompetent mice显示文摘 | Su C Peng L Sham J | 2006 | Mol Ther2006，13，5： | 1 |
| 14 | Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient anti-tumor activity in immunodeficient and immunocompetent mice显示文摘 | Su C Peng I Sham J | 2006 | Mol Ther2006，13，5： | 1 |
| 15 | Texture of vacuum microwave dehydrated apple chips as affected by calcium pretreatment,vacuum level,and apple variety显示文摘 | Sham P W Y Scaman C H Durance T D | | 0，，： | 1 |
| 16 | Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains 显示文摘 | Zhao C Sham H L Sun M H | 2005 | Bioorg Med Chem Lett2005，15，24： | 1 |
| 17 | Monte Carlo tests for associations between disease and alleles at highly polymorphic loci 显示文摘 | Sham P C Curtis D | 1995 | Ann Hum Genet1995，59，1： | 1 |
| 18 | An extended transmission/disequilibrium test (TDT) for multi-allele marker loci显示文摘 | SHAM P C CURTIS D | 1995 | Ann Hum Genet1995，59，2： | 1 |
| 19 | The influence of shallow gas on the geotechnical properties of fine-grained sediments显示文摘 | Wheeler S J Sills G C Sham W K | 1991 | Journal of the Society for Underwater Technology1991，17，3： | 1 |
| 20 | SOX10 is abnormally expressed in aganglionic bowel of Hirsehsprung’s disease infants显示文摘 | Sham M H Lui V C Fu M | 2001 | Gut2001，49，2： | 1 |
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