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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Spectral selectivity in infrared thermal detection显示文摘A review is made of the physics and technology of spectrally selective thermal detectors,especially those operating at non-cryogenic temperatures.The background radiation noise fluctuations are rederived for arbitrary spectral characteristics.Infrared absorption due to phonons and free carriers is discussed followed by a review of published works on artificial infrared absorption materials such as patterned grids,nanoparticles,plasmonic structures,metamaterials and others.Subsequently,the literature of the spectral characteristics of broadband thermal detectors and spectrally selective thermal detectors is reviewed.Finally,the authors speculate on the directions that future research and development in the area will take regarding architectures,sensitivity and spectral characteristics. | Joseph J Talghader Anand S Gawarikar Ryan P Shea | 2012 | Light(Science & Applications)2012，1，1： | 6 |
| 3 | 蛋白酶和木聚糖酶对育肥猪的生长性能、营养消化率以及粪便气味的影响显示文摘菜籽粕(RSM)和小麦干酒糟及其可溶物(DDGS)作为副产物可应用到猪的日粮中。然而,与小麦和豆粕型日粮相比,RSM和DDGS中含有较高的非淀粉多糖(NSP),其可限制猪对日粮的有效利用。采用2×2因素试验设计研究生长育肥猪饲粮中添加木聚糖酶(0和200mg·kg-1)和蛋白酶(0和200mg·kg-1)对其生长性能、胴体品质、表观回肠消化率、全消化道养分消化率及粪便气体排放的影响及两种酶之间的相互作用。试验1,对猪的生长性能进行评估。将体重为34.2±2.1kg的育肥猪128头随机分配到4个处理组:以DDGS(300g·kg-1)和RSM(210g·kg-1)的基础日粮;基础日粮中添加蛋白酶200mg·kg-1;基础日粮中添加木聚糖酶200mg·kg-1;基础日粮中添加蛋白酶200mg·kg-1和木聚糖酶200mg·k-1。试验1中,在生长育肥-出栏期间(0~出栏),日粮中添加蛋白酶的试验猪较不添加蛋白酶的试验猪相比具有较低的平均日增重(ADG)(P〈0.001)。生长阶段(0—28d),蛋白酶和木聚糖酶对猪的日均采食量(ADFI,P〈0.01)和体重(BW,P〈0.01)的影响存在相互作用。在育肥阶段(28d~出栏),日粮中添加蛋白酶和木聚糖酶的试验猪与仅添加一种没酶的试验猪相比具有较低的ADFI和BW。然而,蛋白酶和木聚糖酶的相互作用在生长期间(0~28d)内并不显著。试验2,选择体重78±2.3kg公猪24只,将其置于代谢笼中进行代谢试验,试验期间按照试验l中的日粮进行饲喂。木聚糖酶和蛋白酶对总能(GE)中的AID存在相互作用(P〈0.05)。与对照组相比,饲粮中添加蛋白酶可以增加GE中的AID,但饲粮中添加两种酶时可降低GE中的AID。饲粮中添加木聚糖酶交不添加木聚糖组相比,猪粪便的臭气排放量降低(598和1306OuE/m3;P〈0.05)。研究表明,蛋白酶可提高GE的AID;木聚糖酶可以减少粪便异味的排放,然而当生长猪育肥以RSM和DDGS为基础饲粮时,两种酶均不能提高其生长性能。 | O'Shea C J Mc Alpine P O Solan P Curran T Varley P F Walsh A M Doherty J V O | 2014 | 饲料博览2014，0，10： | 4 |
| 4 | Non-viral vector delivery from PEG-hyaluronic acid hydrogels 显示文摘 | Wieland J A Houchin-Ray T L Shea L D | 2007 | J Control Release2007，120，3： | 1 |
| 5 | Simultaneous identification of bacterial virulence genes by negative selection显示文摘 | Hensel M Shea J E Holden D W etal | 1995 | Science1995，269，： | 1 |
| 6 | Gray-scale ma-sks for diffractive-optics fabrication:I Commercial slide imagers显示文摘 | Thomas J Suleski Donald C O'Shea | 1995 | Applied Optics1995，34，32： | 1 |
| 7 | Enhanced detection of nanostructures by scanning electron microscopy using insulating materials显示文摘 | O'Shea A Wallace J Hummel M | 2013 | Micron2013，5253，8： | 1 |
| 8 | Diabetic retinopathy显示文摘 | Infeld D A O'Shea J G | 1998 | Postgrad Med J1998，74，： | 1 |
| 9 | The effect of protease and xylanase enzymes on growth performance, nutrient digestibility, and manure odour in grower-finisher pigs 显示文摘 | SHEA C J O MC ALPINE P O SOLAN P | 2014 | Animal Feed Science and Technology2014，189，： | 1 |
| 10 | Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptorβgene due to activation of Wnt/β-catenin protein signaling显示文摘 | O′SHEA P J KIM D W LOGAN J G | 2012 | J Biol Chem2012，287，17： | 1 |
| 11 | Halide salts acceleratedegradation of high explosives by zerovalent iron 显示文摘 | Kim J S Shea P J Yang J E ef al | 2007 | Environmental Pollution2007，147，3： | 1 |
| 12 | Arylsilsesquioxane gels and related materials new hybrids of organic and inorganic networks显示文摘 | K J Shea D A Loy O Webster | 1992 | J Am Chem Soc1992，114，17： | 1 |
| 13 | Noise in gene expression: origins, consequences, and control 显示文摘 | Raser J M O'Shea E K | 2005 | Science2005，309，： | 1 |
| 14 | DNA delivery frompolymer matrices for tissue engineering显示文摘 | Shea LD Smiley E Bonadio J | 1999 | Nat Biotechnol1999，17，6： | 1 |
| 15 | Pre-B-cell colony-enhancing factor,whose expression is up-regulated in activated lymphocytes,is a nicotinamide phosphoribosyltransferase,a cytosolic enzyme involved in NAD biosynthesis显示文摘 | Rongvaux A Shea R J Mulks M H | 2002 | Eur J Immunol2002，32，11： | 1 |
| 16 | The use of medial and lateral surgical approaches for the treatment of tibial plafond fractures 显示文摘 | CHEN L O'SHEA K EARLY J S | 2007 | J Orthop Trauma2007，21，3： | 1 |
| 17 | Control of stochasticity in Eukaryotic gene expression 显示文摘 | Raser J M O'Shea E K | 2004 | Science2004，304，： | 1 |
| 18 | A stereologic study of glomertroophy in the subtotally nephrectomized rat 显示文摘 | Shea SM Raskora J Morrison AB | 1978 | Am J Pathol1978，90，： | 1 |
| 19 | Adaptations in cortical and trabecular bone in response to mechanical loading with and without weight bearing显示文摘 | WARNER S E SHEA J E MILLER S C | 2006 | Calcif Tissue Int2006，79，6： | 1 |
| 20 | Pilot -scale treatment of RDX-contaminated soil with zerovalent iron显示文摘 | Comfort S D Shea P J Machacek T A | 2003 | J Environ Qual2003，32，： | 1 |
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