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| 1 | Unusual presentations of eosinophilic gastroenteritis:Case series and review of literature显示文摘Eosinophilic gastroenteritis (EG) is an uncommon disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract, and is usually associated with dyspepsia, diarrhea and peripheral eosinophilia. Diffuse gastrointestinal tract and colonic involvement are uncommon. The endoscopic appearance may vary from normal to mucosal nodularity and ulceration. Gastrointestinal obstruction is unusual and is associated with predominantly muscular disease. We present five unusual cases of EG associated with gastric outlet and duodenal obstruction. Two cases presented with acute pancreatitis and one had a history of pancreatitis. Four cases responded well to medical therapy and one had recurrent gastric outlet obstruction that required surgery. Four out of the five cases had endoscopic and histological evidence of esophagitis and two had colitis. Two patients had ascites. These cases reaffirm that EG is a disorder with protean manifestations and may involve the entire gastrointestinal tract. Gastric outlet and/or small bowel obstruction is an important though uncommon presentation of EG. It may also present as esophagitis, gastritis with polypoid lesions, ulcers or erosions, colitis and pancreatitis and may mimic malignancy. | Rafiq A Sheikh Thomas P Prindiville R Erick Pecha Boris H Ruebner | 2009 | World Journal of Gastroenterology2009，15，17： | 43 |
| 2 | Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages显示文摘AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of cancer.METHODS:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University Hospital.Patient demographic information,including age and gender,tumor sites,and histological type of CRC,was recorded.To measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal tissues.Reverse transcription and reverse transcription polymerase chain reaction were performed.Colorectal tissue microarrays were constructed to investigate the protein expression of TNF-a by immunohistochemistry.RESULTS:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal tissue.High TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were negative.We showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of tumor.CONCLUSION:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC. | Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 3 | 基于SMA和ECC复合材料的功能自恢复剪力墙抗震性能试验研究显示文摘剪力墙作为高层建筑广泛采用的水平抗侧力构件,承担着结构绝大部分的水平地震作用。因此,剪力墙受力性能的优劣对整个建筑结构的抗震性能尤为重要。为提高剪力墙的变形能力,减小剪力墙的损伤和残余变形,实现震后的快速恢复,提出一种具有自复位功能的剪力墙。在该剪力墙塑性铰区采用形状记忆合金筋(Shape Memory Alloy,简称SMA)替代纵向钢筋,实现墙体的自复位功能;采用工程水泥基复合材料(Engineered Cementitious Composites,简称ECC)替代普通混凝土,解决混凝土的脆性剥落损伤。为检验新型剪力墙的抗震性能,设计制作4个剪力墙试件,分别为普通混凝土剪力墙、高延性ECC增强剪力墙、超弹性SMA增强剪力墙和SMA和ECC共同增强剪力墙,并进行低周往复荷载试验,对比分析剪力墙的破坏模式以及承载力、自复位能力、延性、耗能能力等抗震性能。研究结果表明:与普通钢筋混凝土剪力墙相比,SMA和ECC共同增强剪力墙不仅损伤小,实现功能的快速修复,而且自复位能力达到85%以上,构件复位效果显著;同时表现出较好的延性。 | 钱辉 康莉萍 郭院成 李宗翱 Shamim A Sheikh | 2020 | 土木工程学报2020，53，10： | 8 |
| 4 | Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy显示文摘AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible bronchoscopy.METHODS A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were reviewed.RESULTS Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. Children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of hypoxemia.CONCLUSION Children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers. | Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed Elizabeth A S Moser Renee C McKinney Riad Lutfi | 2017 | World Journal of Critical Care Medicine2017，6，4： | 8 |
| 5 | Negundoside,an irridiod glycoside from leaves of Vitex negundo,protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride显示文摘AIM:To evaluate the protective effect of 2'-p-hydroxy benzoylmussaenosidic acid [negundoside(NG) ,against carbon tetrachloride(CCl4) -induced toxicity in HuH-7 cells. METHODS:CCl4 is a well characterized hepatotoxin,and inducer of cytochrome P450 2E1(CYP2E1) -mediated oxidative stress. In addition,lipid peroxidation and accumulation of intracellular calcium are important steps in the pathway involved in CCl4 toxicity. Liver cells(HuH-7) were treated with CCl4,and the mechanism of the cytoprotective effect of NG was assessed. Silymarin,a known hepatoprotective drug,was used as control. RESULTS:NG protected HuH-7 cells against CCl4 toxicity and loss of viability without modulating CYP2E1 activity. Prevention of CCl4 toxicity was associated with a reduction in oxidative damage as reflected by decreased generation of reactive oxygen species(ROS) ,a decrease in lipid peroxidation and accumulation of intracellular Ca2+ levels and maintenance of intracellular glutathione homeostasis. Decreased mitochondrial membranepotential(MMP) ,induction of caspases mediated DNA fragmentation and cell cycle arrest,as a result of CCl4 treatment,were also blocked by NG. The protection afforded by NG seemed to be mediated by activation of cyclic adenosine monophosphate(cAMP) synthesis and inhibition of phospholipases(cPLA2) . CONCLUSION:NG exerts a protective effect on CYP2E1-dependent CCl4 toxicity via inhibition of lipid peroxidation,followed by an improved intracellular calcium homeostasis and inhibition of Ca2+-dependent proteases. | Sheikh A Tasduq Peerzada J Kaiser Bishan D Gupta Vijay K Gupta Rakesh K Johri | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 6 | Seismic behavior of concrete columns confined with steel and fiber-reinforced polymers 显示文摘 | SHEIKH S A YAU G | 2002 | ACI Struct J2002，99，1： | 2 |
| 7 | Stiffened steel plates under combined compression and bending 显示文摘 | Sheikh I A Elwi A E Grondin G Y | 2003 | Journal of Constructional Steel Research2003，59，： | 1 |
| 8 | Effect of hyperoxia on vascular endothelial growth factor levels in a wound model显示文摘 | Sheikh A Y Gibson J J Rollins M D | 2000 | Arch Surg2000，135，11： | 1 |
| 9 | Image quality assessment:from error visibility to structural similarity显示文摘 | WANG ZHOU BOVIK A C SHEIKH H R | 2004 | IEEE Transactions on Image Processing2004，13，4： | 1 |
| 10 | An information fidel- ity criterion for image quality assessment using natural scene statis- tics显示文摘 | SHEIKH H R BOVIK A C de VECIANA G | 2005 | IEEE Transactions on Image Processing2005，14，12： | 1 |
| 11 | Image Quality Assessment:From Error Visibility to Structural Similarity显示文摘 | Wang Z Bovik A C Sheikh H R | 2004 | IEEE Transactions on Image Processing2004，13，4： | 1 |
| 12 | Image quality assess- ment: from error visibility to structural similarity 显示文摘 | Wang Zhou Bovik A C Sheikh H R | 2004 | IEEE Trans on Signal Processing2004，13，4： | 1 |
| 13 | Confined Concrete Columns with Stubs 显示文摘 | SHEIKH S A KHOURY S S | 1993 | ACI Structural Journal1993，90，4： | 1 |
| 14 | Influence of humeral prosthesis height on biomechanics of glenohumeral abduction:An in vitro study显示文摘 | Nyffeler R W Sheikh R Jacob H A | 2004 | J Bone Joint Surg Am2004，86，3： | 1 |
| 15 | Image Quality Assessment;From Error Visibility to Structural slmilarity显示文摘 | Wang Zhou Bovik A C Sheikh H R | 2004 | IEEE Transactions on Image Processing2004，13，4： | 1 |
| 16 | Analytical model for concrete confinement in tied columns 显示文摘 | Sheikh S A Uzumeri S M | 1982 | Journal of the Structural Division ASCE1982，108，12： | 1 |
| 17 | Confinement reinforcement design considerations for ductile HSC columns 显示文摘 | Bayrak O Sheikh S A | 1998 | Journal of Structural Engineering ASCE1998，124，9： | 1 |
| 18 | Image qual- ity assessment: from error visibility to structural sim- ilarity 显示文摘 | ZHOU W BOVIK A C SHEIKH H R | 2004 | IEEE Transactions on Image Processing2004，13，2： | 1 |
| 19 | Image quality assess- ment: from error visibility to structural similarity 显示文摘 | Wang Z Bovik A C Sheikh H R | 2004 | IEEE Transactions on Image Processing2004，13，4： | 1 |
| 20 | Coupling of grain boundary sliding and migration within the range of boundary special ness显示文摘 | Sheikh Ali A D | 2010 | ActaMaterialia2010，58，： | 1 |
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