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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | The Photochemical Study of HSA and BSA with Resonance Light Scattering and Fluorescence Spectra显示文摘The resonance light-scattering (RLS) of human serum albumin (HSA) and bovine serum albumin (BSA) is reported for the first time, and applied to study photochemical reaction of HSA and BSA. The fact of photocrosslinking self-association effect in HSA and BSA solutions is identified by the enhancement of RLS. The fluorescence quenching at about 350 um and 700 um proves that tryptophan (Trp) residues are one of the photochemical activity sites in HSA and BSA molecules. The Rayleigh scattering (RS) spectra of HSA and BSA that were neglected in fluorescence spectra before are found at about 296 um, 592 um and 888 um for the first time, and are of adventageous to studying the aggregation of HSA or BSA. The possible photochemical reaction mechanism is also proposed. | Liang, H Shen, XC Li, F Jiang, ZL | 2000 | Chinese Chemical Letters2000，11，3： | 4 |
| 3 | A route-neighborhood-based metaheuristic for vehicle routing problem with time windows 显示文摘 | Shen S Y | 1999 | European Journal of Operational Research1999，118，： | 1 |
| 4 | Analysis on the weld defects of AZ91D magnesium alloy joints显示文摘 | YE H YAN Z L SHEN B XUE Z F | 2009 | Materials Science Forum2009，610，： | 1 |
| 5 | Mathematical models for local non-texture inpainting 显示文摘 | Chan T F Shen J H | 2001 | SIAM Journal of Applied Mathematics (S0036-1429)2001，62，3： | 1 |
| 6 | Tape-Arabidopsis Sandwich - a simpler Arabidopsis protoplast isolation method 显示文摘 | Wu F H Shen S C Lee L Y | 2009 | Plant Methods2009，5，16： | 1 |
| 7 | A High Precision Direct Integration Scheme for Structures Subjected to Transient Dynamic Loading显示文摘 | Lin J H Shen W P Williams F W | 1995 | Computers and Structures1995，56，1： | 1 |
| 8 | A High Precise Direct Integration Scheme for Structures Subjected to Transient Dynamic Loading显示文摘 | LIN J H SHEN W P WILLIAMS F W | 1995 | Computer & Structures1995，56，2： | 1 |
| 9 | Euler's Elastiea and Curvature Based Inpainting显示文摘 | Chan T F Kang S H Shen J H | 2002 | SIAM Journal of Applied Mathematics2002，63，2： | 1 |
| 10 | Evaluation of adeno-associated virus-mediated gene transfer into the rat retina by clinical fluorescence photography显示文摘 | ROLLING F SHEN W Y TABARISA H | 1999 | Hum Gene Ther1999，10，： | 1 |
| 11 | SNP rs6265 regulates protein phosphorylation and osteoblast differentiation and influences BMD in humans显示文摘 | Deng F Tan LJ Shen H | 2013 | Journal of Bone and Mineral Research2013，28，12： | 1 |
| 12 | Changes in salt extractable protein and Ca2+-ATPase activity of mince from silver carp(hypophthalmichthys mollitrix)during frozen storage:A kinetic study显示文摘 | Pan J F Shen H X Luo Y K | 2010 | Jorunal of Muscle Foods2010，21，： | 1 |
| 13 | Comparative mapping of QTLs for agronomic traits of rice across environment by using a doubled-haploid population显示文摘 | Lu C F Shen L H Tan Z B | 1997 | Theor Appl Genet1997，94，1： | 1 |
| 14 | Dual lixiviant leaching process for extraction and re- covery of gold from ores at room temperature 显示文摘 | Zhang J T Shen S B Cheng Y Lan H F Hu X Wang F | 2014 | Hy- drometallurgy2014，144，145： | 1 |
| 15 | Nontexture inpainting by curvature driven diffusions显示文摘 | Chan T F Shen J H | 2001 | Visual Communication and Image Representation2001，12，4： | 1 |
| 16 | Fission trakc dating of Mesozoic sandstone and its tectonic significance in the Eastern Si chuan basin, China显示文摘 | Shen C B Mei L F Xu S H | 2009 | Radiation Measurements2009，44，： | 1 |
| 17 | Broadband and high-efficiency conversion from guided waves to spoof surface plasmon polaritons显示文摘 | MA H F SHEN X CHENG Q | 2013 | Laser Photon Rev2013，110，1： | 1 |
| 18 | An artificial neural network ensemble method for fault diagnosis of proton exchange membrane fuel cell system显示文摘 | Shao M Zhu X J Cao H F and Shen H F | 2014 | Energy2014，67，： | 1 |
| 19 | Adaptive back-stepping sliding mode control for linear inductionmotor显示文摘 | LIN F J SHEN P H HSU S P | 2002 | IEEE Proceedings Electric Power Application2002，14，9： | 1 |
| 20 | Studies of decomposition of H2O2 over manganese oxide octahedral molecular sieve materials 显示文摘 | Zhou H Shen Y F | 1998 | Journal of Catalysis1998，176，： | 1 |
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