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| 1 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 2 | Adaptive local refinement with octree local - balancing for the parallel solution of three - dimensional conservation laws显示文摘 | Flaherty J F Loy R M Shephard M S | 1997 | Journal of Pantllel and Distributed Computing1997，47，： | 1 |
| 3 | Filtering via simulation: Auxiliary particle filters显示文摘 | PITT M SHEPHARD N | 1999 | Journal of the American Statistical Association1999，94，446： | 1 |
| 4 | On the generality of the 'sit and reach' test: an analysis of flexibility data for an aging population 显示文摘 | Shephard RJ Berridge M Montelpare W | 1990 | Res Quart Exere Sport1990，61，4： | 1 |
| 5 | Headgroup effect on silane structures at buried polymer/silane and polymer/polymer interfaces and their relations to adhesion显示文摘 | Zhang C Shephard N E Rhodes S M | 2012 | Langmuir2012，28，14： | 1 |
| 6 | Filtering via simulation: auxiliary particle filters显示文摘 | Pitt M K Shephard N | 1999 | JASA1999，94，446： | 1 |
| 7 | Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3)显示文摘 | Allerston CK Shimizu M Fujieda M Shephard EA Yamazaki H Phillips IR | 2007 | Pharmacogenet Genomics2007，17，10： | 1 |
| 8 | Filtering via simulation:Aux-iliary particle filters显示文摘 | Pitt M Shephard N | 1999 | J Amer Statist Assoc1999，94，446： | 1 |
| 9 | Discontinuous Galerkin Methods Applied to Shock and Blast Problems显示文摘 | Chevaugeon N Xin J Hu P Li X Cler D Flaherty J E and Shephard M S | 2005 | Journal of Scientific Computing2005，2，： | 1 |
| 10 | Degradation of microcystin toxins in a falling film photocatalytic reactor with immobilized titanium dioxide catalyst显示文摘 | SHEPHARD G S STOCKENSTRE M S DEVILLIERS D et al | 2002 | Water Res2002，36，1： | 1 |
| 11 | Automatic three di mensional mesh generation by the finite octree tech nique显示文摘 | Shephard M S Georges M K | 1991 | International Journal for Numerical Meth ods in Engineering1991，32，4： | 1 |
| 12 | Filtering via simulation: auxiliary particle filters显示文摘 | Pitt M Shephard N | 1999 | Journal of the American Statistical Association1999，94，446： | 1 |
| 13 | Filtering via simulation: Auxiliary particle filters显示文摘 | Pitt M Shephard Neil | 1999 | Journal of the American statistical Asso- ciation1999，94，446： | 1 |
| 14 | Approaches to the Automatic Generation and Control of Finite Element Meshes 显示文摘 | SHEPHARD M S | 1988 | Applied Mechanics Review1988，41，4： | 1 |
| 15 | Filtering via simulation:auxiliary particle filters显示文摘 | Pitt M K Shephard N | 1999 | Journal of the American Statistical Association1999，94，446： | 1 |
| 16 | Filtering via simulation: Auxiliary particle filters 显示文摘 | PITT M K SHEPHARD N | 1999 | Journal of the American Statistical Association1999，94，2： | 1 |
| 17 | The presence of ammonium facilitates nitrite reduction under PHB driven simultaneous nitrification and denitrification显示文摘 | GIBBS B M SHEPHARD L R THIRD K A | 2004 | Water Science and Technology2004，50，10： | 1 |
| 18 | New Venture Survival: Ignorance, External Shocks, and Risk Reduction Strategies 显示文摘 | Shephard D A Douglas E J and M Shanley | 2000 | Journal of Business Ventur- ing2000，15，56： | 1 |
| 19 | Limit theorems for multipower variation in the presence of jumps显示文摘 | Barndorff-Nielsen O E Shephard N Winkel M | 2006 | Stochastic Processes and Their Applica- tions2006，116，： | 1 |
| 20 | Filtering via simulation: Auxiliary particle filters 显示文摘 | M Pitt N Shephard | 1999 | Journal of the American Statistical Association (S0162-1459)1999，94，446： | 1 |
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