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48篇 您的检索式：作者名="Shields O"

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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	爱尔兰海洋经济和资源显示文摘什么是爱尔兰? 这或许是个奇怪的问题。目前还很少有人认为爱尔兰是一个海洋国家。如果有人认为爱尔兰由9万平方公里的陆域面积和90万平方公里的海域面积组成,就更加稀奇了。	Y Shields J O’Cornor J O’Leary 周怡圃王占坤羊志洪	2010	经济资料译丛2010，，1：	4
3	Retinal pigment epithelium in ineontinentia pigmenti 显示文摘	Mensheha-Manhart O Rodrigues MM Shields JA	1975	Am J Ophthalmol1975，79，4：	1
4	Short-circuit test on current-limiting fuse modeling of the test circuit显示文摘	Wilkins R Saengsuwan T Shields L O'	1993	IEE Proceedings-Generation Trensmission and Distribution1993，140，1：	1
5	Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands显示文摘	Heather M. O’Hagan Wei Wang Subhojit Sen Christina DeStefano Shields Stella S. Lee Yang W. Zhang Eriko G. Clements Yi Cai Leander Van Neste Hariharan Easwaran Robert A. Casero Cynthia L. Sears Stephen B. Baylin	2011	Cancer Cell2011，，5：	1
6	Benign epilepsy with centrotemporal spikes显示文摘	Shields W D Snead O C 3rd	2009	Epilepsia2009，50，8：	1
7	Lowerlimb blocks显示文摘	Murray J M Derbyshire S Shields M O	2010	Anaesthesia2010，65，：	1
8	Lack of association between NFKBIL1/LTA polymorphisms and hypertension, myocardial infarct, unstable angina and stable angina in a large Irish population sample 显示文摘	Ryan A W O'Brien E Shields D	2008	Atheroselerosis2008，197，1：	1
9	Climate scenarios for the Southeast US based on GCM and regional modeling simulations显示文摘	Mearns L O F Giorgi L McDaniel C Shields		0，，：	1
10	Implementing integrated oceans management: Australia's south east regional marine plan and Canada' s eastern scotia shelf integrated management initiative 显示文摘	Y Shields J O' Connor	2005	Marine Policy2005，29，5：	1
11	Kinetics of 3'-deoxy-3'-18F fluorothymidine uptake and retention in dogs显示文摘	Shields AF Grierson JR Muzik O	2002	Mol Imaging Biol2002，4，1：	1
12	Periocular Triamcinolone for Prevention of Macular Edema after Plaque Radiotherapy of Uveal Melanoma显示文摘	Noel Horgan Carol L. Shields Arman Mashayekhi Pedro F. Salazar Miguel A. Materin Myra O’Regan Jerry A. Shields	2009	Ophthalmology2009，，7：	1
13	Short-circuit Test on Current-limiting Fuse Modeling of the Test Circuit显示文摘	WILKINS R SAENGSUWAN T SHIELDS L O	1993	IEE Proceedings1993，140，1：	1
14	Lower limb blocks显示文摘	MURRAY J M DERBYSHIRE S SHIELDS M O	2010	Anaesthesia2010，651，：	1
15	Breasffeeding and obesity at 21 years:a cohort study显示文摘	Shields L Mamun AA O 'callaghan M ctal	2010	Journal of Clinical Nursing2010，19，1112：	1
16	The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to Ⅱ b/Ⅲ a antagonists显示文摘	Shields DC Fitzgerald AP O' Neill PA		0，，：	1
17	Idiopathic hydronephrosis - the diuresis renogram : A new non - invasive method of assessing equivocal pelvioureteral junction obstruction 显示文摘	O' Reilly PH Lawson RS Shields RA	1979	J Urol1979，121，2：	1
18	State-funded tourism marketing: The effectiveness of state travel guides for the college market 显示文摘	Shields P O	2006	Journal of Travel & Tourism Marketing2006，20，2：	1
19	Idiopathic hydronephrosis-the diuresis renogram:A new non-invasive method of assessing equivocal pelvioureteral junction obstruction显示文摘	Lawson RS Shields RA	1979	J Uro11979，121，2：	1
20	The binding site on human immunoglobulin E for its high affinity receptor 显示文摘	Presta L Shields R O'Connell L	1994	J Biol Chem1994，269，26：	1

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