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| 1 | Metabolic syndrome and risk of subsequent colorectal cancer显示文摘The metabolic syndrome and visceral obesity have anincreasing prevalence and incidence in the generalpopulation. The actual prevalence of the metabolicsyndrome is 24% in US population and between24.6% and 30.9% in Europe. As demonstrated by many clinical trials (NAHANES , INTERHART) the metabolic syndrome is associated with an increased risk of both diabetes and cardiovascular disease. In addition to cardiovascular disease, individual components of the metabolic syndrome have been linked to the development of cancer, particularly to colorectal cancer. Colorectal cancer is an important public health problem; in the year 2000 there was an estimated total of 944 717 incident cases of colorectal cancer diagnosed world-wide. This association is sustained by many epidemiological studies. Recent reports suggest that individuals with metabolic syndrome have a higher risk of colon or rectal cancer. Moreover, the clusters of metabolic syndrome components increase the risk of associated cancer. The physiopathological mechanism that links metabolic syndrome and colorectal cancer is mostly related to abdominal obesity and insulin resistance. Population and experimental studies demonstrated that hyperinsulinemia, elevated C-peptide, elevated body mass index, high levels of insulin growth factor-1, low levels of insulin growth factor binding protein-3, high leptin levels and low adiponectin levels are all involved in carcinogenesis. Understanding the pathological mechanism that links metabolic syndrome and its components to carcinogenesis has a major clinical signifi cance and may have profound health benefi ts on a number of diseases including cancer, which represents a major cause of mortality and morbidity in our societies. | Raluca Pais Horatiu Silaghi Alina Cristina Silaghi Mihai Lucian Rusu Dan Lucian Dumitrascu | 2009 | World Journal of Gastroenterology2009，15，41： | 16 |
| 2 | Is epicardial adipose tissue,assessed by echocardiography,a reliable method for visceral adipose tissue prediction?显示文摘 | SILAGHI A C POANTA L VALEA A | 2011 | Med Ultrason2011，13，： | 1 |
| 3 | Operative outcomes of robot-assisted transaxillary thyroid surgery for benign thyroid disease: early experience in 50 patients显示文摘 | Axente DD Silaghi H Silaghi CA | 2013 | Langenbecks Arch Surg2013，398，6： | 1 |
| 4 | Infections with Anaplasrna phago- cytophilumin in dogs in Germany显示文摘 | Kohn B Silaghi C Galke D | 2011 | Res Vet Sci2011，91，1： | 1 |
| 5 | Genetic variants of Anaplas- ma phagocytophilum in wild caprine and cervid ungulates from the Alps in Tyrol, Austria显示文摘 | Silaghi C Hamel D Thiel C | 2011 | Vector Borne Zoonotic Dis2011，11，4： | 1 |
| 6 | Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status显示文摘 | Silaghi A Achard V Paulmyer-Lacroix O | 2007 | Am J Physiol Endocrinol Metab2007，293，5： | 1 |
| 7 | A time-constrained SLA negotiation strategy in competitive computational grids显示文摘 | SILAGHI G C SERBAN L D LITAN C M | 2012 | Fu- ture Generation Computer Systems2012，28，8： | 1 |
| 8 | Local and global skeleton fitting techniques for optical motion capture 显示文摘 | Silaghi M C Plankers R Boulic R | 1998 | Modeling and Motion Capture Techniques for Virtual Environments1998，1537，： | 1 |
| 9 | Status o the Southern Carpathian forests in the long-- term ecological research network 显示文摘 | Badea O Bytnerowicz A Silaghi D | 2012 | Environmental monitoring and assessment2012，，19： | 1 |
| 10 | Asynchronous aggregation and consistency in distributed constraint satisfaction显示文摘 | Silaghi M C Faltings B | 2005 | Artificial Intelligence2005，161，12： | 1 |
| 11 | Implementing and Running a Workflow Application on Cloud Resources显示文摘 | MORAR G A MUNTEAN C I SILAGHI G C | 2011 | Informatica Economica2011，15，3： | 1 |
| 12 | Epicardial adipose tissue extent:relationship with age, body fat distribution, and coronaropathy显示文摘 | Silaghi A Piercecchi - Marti MD | 2008 | Obesity ( Silver Spring)2008，16，11： | 1 |
| 13 | Epicardial adipose tissue extent: relationship with age, body fat distribution, and coronaropathy显示文摘 | Silaghi A Piercecchi-Marti MD Grino M | 2008 | Obesity2008，16，11： | 1 |
| 14 | Highly pathogenic H5N1and novel H7N9influenza A viruses induce more profound proteomic host responses than seasonal and pandemic H1N1strains显示文摘 | Simon P F McCorrister S Hu P Chong P Silaghi A Westmacott G Coombs K M Kobasa D | 2015 | J Proteome Res2015，14，11： | 1 |
| 15 | Synovial and serum levels of uncarboxylated matrix Gla-protein (ucMGP) in patients with arthritis显示文摘 | Silaghi C N Fodor D Cristea V | 2011 | Clin Chem Lab Med2011，，： | 1 |
| 16 | Implementing and Running a Workflow Application on Cloud Resources 显示文摘 | MORAR G A MUNTEAN C I SILAGHI G C | 2011 | Informatica Economica2011，15，3： | 1 |
| 17 | Vacuum ultraviolet spectroscopic elipsometry investigations of guanine layers on H-passivated Si(111) surfaces显示文摘 | Silaghi S D Friedrich M Scholz R | 2004 | Thin Solid Films(S0040-6090)2004，，： | 1 |
| 18 | Operative outcomes of robot-assisted transaxillary thyroid surgery for benign thyroid dis- ease: early experience in 50 patients显示文摘 | Axente DD Silaghi H Silaghi CA | 2013 | Langenbecks Arch Surg2013，398，6： | 1 |
| 19 | Challenges on molecular aspects of dealumination and desilication of zeolites 显示文摘 | Silaghi M C Chizallet C Raybaud P | 2014 | Micro- porous and Mesoporous Haterials2014，，191： | 1 |
| 20 | Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status 显示文摘 | Silaghi A Achard V Paulmyer-Lacroix O | 2007 | Am J Physiol Endocrinol Metab2007，93，5： | 1 |
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