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| 1 | Malnutrition in cirrhosis:More food for thought显示文摘Malnutrition is highly prevalent in liver cirrhosis and its presence carries important prognostic implications.The clinical conditions and pathophysiological mechanisms that cause malnutrition in cirrhosis are multiple and interrelated.Anorexia and liver decompensation symptoms lead to poor dietary intake;metabolic changes characterised by elevated energy expenditure,reduced glycogen storage,an accelerated starvation response and protein catabolism result in muscle and fat wasting;and,malabsorption renders the cirrhotic patient unable to fully absorb or utilise food that has been consumed.Malnutrition is therefore a considerable challenge to manage effectively,particularly as liver disease progresses.A high energy,high protein diet is recognised as standard of care,yet patients struggle to follow this recommendation and there is limited evidence to guide malnutrition interventions in cirrhosis and liver transplantation.In this review,we seek to detail the factors which contribute to poor nutritional status in liver disease,and highlight complexities far greater than“poor appetite”or“reduced oral intake”leading to malnutrition.We also discuss management strategies to optimise nutritional status in this patient group,which target the inter-related mechanisms unique to advanced liver disease.Finally,future research requirements are suggested,to develop effective treatments for one of the most common and debilitating complications afflicting cirrhotic patients. | Brooke Chapman Marie Sinclair Paul J Gow Adam G Testro | 2020 | World Journal of Hepatology2020，12，11： | 8 |
| 2 | Basic aspects of the co-deformation of bcc/fcc materials显示文摘 | SINCLAIR C W EMBURY J D WEATHERLY G C | 1999 | Materials Science and Engineering1999，272，： | 1 |
| 3 | Feeding tuna oil to the sow at different times during pregnancy has different effects on piglet long-chain polyunsaturated fatty acid composition at birth and subsequent growth显示文摘 | Rooke J A Sinclair A G Edwards S A | 2001 | British Journal of Nutrition2001，86，1： | 1 |
| 4 | Future contributions of crop modeling-from heuristics and supporting decision making to understanding genetic regulation and aiding crop improvement显示文摘 | Hammer G L Kropff M J Sinclair T R | 2002 | Eur J Agron2002，18，： | 1 |
| 5 | Nutritionaleffects on fatal growth 显示文摘 | RobinsonJ J Sinclair K D McEvoy T G | 1999 | Animal Science1999，，68： | 1 |
| 6 | Production of iturin A by Bacillus amyloliquefaciens suppressing Rhizoetonia solani 显示文摘 | Yu G Y Sinclair J B Hartman G L | 2002 | Soil Biology & Biochemistry2002，34，： | 1 |
| 7 | Production of iturin A by Bacillus amloliquefaciens suppressing Rhizoctonnia solani 显示文摘 | Yu G Y Sinclair J B Hartman G L | 2002 | Soil Biology and Biochemistry2002，34，7： | 1 |
| 8 | Human cytomegalovirus latency alters the cellular secretome,inducing cluster of differentiation(CD)4+T-cell migration and suppression of effector function显示文摘 | Mason G M Poole E Sissons J G Wills M R Sinclair J H | 2012 | PNAS2012，109，14： | 1 |
| 9 | Nutritional effectson fetal growth显示文摘 | ROBINSON J J SINCLAIR K D MCEVOY T G | 1999 | J Anim Sci1999，68，： | 1 |
| 10 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 11 | Contact stresses in dovetail attachments:finite element modeling显示文摘 | Sinclair G B Cormier N G Griffin J H | 2002 | Journal of Engineering for Gas Turbines and Power2002，124，1： | 1 |
| 12 | The effect otf feed- ing salmon oil to sows throughout pregancy on pre-weaning mor-tality of piglets显示文摘 | Edwards S A Rooke J A Sinclair A G | 2001 | Newcastle University2001，73，： | 1 |
| 13 | Production of iturin a by Bacillus amyloliquefaciens suppressing Rhizoctonia solani显示文摘 | Yu G Y Sinclair J B Hartman G L | 2002 | Soil Biology and Biochemistry2002，34，： | 1 |
| 14 | The effect of feeding salmon oil to sows throughout pregnancy or pre-weaning mortality of piglets显示文摘 | Rooke J A Sinclair A G Edwards S A | 2001 | Anita Sci2001，73，： | 1 |
| 15 | Basic aspects of the co-deformation of bcc/fcc materials显示文摘 | SINCLAIR C W EMBURY J D WEATHERLY G C | 1999 | Materials Science and Engineering1999，272，： | 1 |
| 16 | Contact stress in dovetail attachments:finite element modeling显示文摘 | Sinclair G B Cormier N G Griffin J H | 2002 | Journal of Engineering for Gas Turbines and Power2002，124，： | 1 |
| 17 | Production of iturin a by Bacillus amyloliquefaciens suppressing Rhizoctonia solani 显示文摘 | Yu G Y Sinclair J B Hartman G L | 2002 | Soil Biology & Biochemistr2002，34，： | 1 |
| 18 | Geology, geochemistry and mineralogy of indium resources at Mount Pleasant, New Brunswick 显示文摘 | SINCLAIR W D KOOIMAN G J A MARTIN D A KJARSGAARD I M | 2006 | Ore Geology Reviews2006，28，1： | 1 |
| 19 | Evapotranspiration of vegetation in Florida: perpetuated misconceptions versus mechanistic processes显示文摘 | Allen H G Sinclair T R Bennett J M | 1996 | Proceedings-Soil and Crop Science Society of Florida1996，56，： | 1 |
| 20 | Production of iturin A by Bacillus amyloliquefadens suppressing Rhizoctonia solani 显示文摘 | YU G Y SINCLAIR J B HARTMAN G L | 2002 | Soil Biol Biochem2002，34，： | 1 |
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