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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | The biolodical degradation of soluble cellulose derivatives and its relationship to the mechanism of cellulose hydrolysis显示文摘 | Reese E T Siu R G H Levenson HS | 1950 | Bacteriol1950，，59： | 1 |
| 3 | Informal social support and older person's psychological well-being in Hong Kong 显示文摘 | David R Phillips Siu QL el al | 2008 | J Cross Cult Gemotol2008，23，1： | 1 |
| 4 | Fluctuations in convex models of endogenous growth,I:growth effects显示文摘 | Jones L E Manuelli R E Siu H E | 2005 | Review of Economic Dynamics2005，8，4： | 1 |
| 5 | Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5显示文摘 | Siu E C Wildenauer D B Tyndale R F | 2006 | Psychopharmacology (Berl)2006，，184： | 1 |
| 6 | Tolerability of the Intergroup 0099 (INT 0099 ) regimen in locally advanced nasopharyngeal cancer with a focus on patients' nutritional status 显示文摘 | BAHL M SIU L L POND G R | 2004 | Int J Radiat Oncol Biol Phys2004，60，8： | 1 |
| 7 | Option pricing and filtering with hidden Markov modulated pure-jump processes显示文摘 | Elliott R J Siu T K | 2013 | Applied Mathematical Finance2013，20，1： | 1 |
| 8 | PAPR reduction of an OFDM sig- nal by use of PTS with low computa- tional complexity 显示文摘 | YANG L CHEN R S SIU Y M | 2006 | IEEE Transac-tions on Broadcasting2006，52，1： | 1 |
| 9 | Three-dimensional echocardiography improves non-invasive assessment of left ventricular volume and performance显示文摘 | SIU S C LEVINE R A RIVERA J M | 1995 | Am Heart J1995，130，7： | 1 |
| 10 | The biological degradation of soluble cellulose derivatives and its relationship to the mechanism of cellulose hydrolysis显示文摘 | Reese E T Siu R G H Levinson H S | | 0，，04： | 1 |
| 11 | Pricing options under a generalized Markov-modulated jump-diffusion model显示文摘 | Elliott R J Siu T K Chan L G | 2007 | Stochastic Analysis and Application2007，25，4： | 1 |
| 12 | PAPR Reduction of an OFDM Signal by Use of PTS with Low Computational Complexity显示文摘 | YANG L CHEN R S SIU Y M | 2006 | IEEE Transactions on Broadcasting2006，52，01： | 1 |
| 13 | Coexpression of neuronatin splice forms promotes medulloblastoma growth 显示文摘 | Siu IM Bai R Gallia GL | 2008 | Neuro Oncol2008，10，5： | 1 |
| 14 | 14-3-3 zeta as novel molecular target for cancer therapy显示文摘 | Matta A Siu KW Ralhan R | 2012 | Expert Opin Ther Targets2012，16，5： | 1 |
| 15 | A study of family support,friend- ship,and psychological well-being among older women in Hong Kong显示文摘 | Siu O L Phillips D R | 2002 | Int J Aging Hum Dev2002，55，4： | 1 |
| 16 | Asset allocation for a DC pension fund under regime switching environment显示文摘 | Korn R Siu T K Zhang A | 2011 | European Actuarial Journal2011，2，： | 1 |
| 17 | Opportunism as the inhibiting trigger for develo- ping long-term-oriented western exporter Hong Kong importer relationships 显示文摘 | Barnes B R Leonidou L C Siu N Y M Leonidou C N | 2010 | Journal of International Marketing2010，18，2： | 1 |
| 18 | Nasopharyngeal carcinoma: the next challenges 显示文摘 | RAZAK A R SIU L L LIU F F | 2010 | Eur J Cancer2010，46，11： | 1 |
| 19 | Rash severity is predictive of increased survival with erlotinib HCI 显示文摘 | Clarke G Perez -Soler R Siu L | 2003 | Proc Am Soc Clin Onco2003，22，： | 1 |
| 20 | Option pricing and Esscher transform under regime switching 显示文摘 | Elliott R J Chan L Siu T K | 2005 | Ann Finance2005，1，： | 1 |
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