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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 3 | Integration of acoustic and articulatory information with application to speech recognition显示文摘 | Leung K Y Siu M H | 2004 | Information Fusion2004，5，2： | 1 |
| 4 | A low complexity selected mapping scheme by use of time domain se-quence superposition technique for PAPR reduction in OFDM system显示文摘 | YANG L SOO K K SIU Y M | 2008 | IEEE Transactions on Broadcast-ing2008，54，4： | 1 |
| 5 | PAPR reduction of an OFDM sig- nal by use of PTS with low computa- tional complexity 显示文摘 | YANG L CHEN R S SIU Y M | 2006 | IEEE Transac-tions on Broadcasting2006，52，1： | 1 |
| 6 | PAPR Reduction of an OFDM Signal by Use of PTS with Low Computational Complexity显示文摘 | YANG L CHEN R S SIU Y M | 2006 | IEEE Transactions on Broadcasting2006，52，01： | 1 |
| 7 | Trait intrinsic and extrinsic motivation, academic performance, and creativity in Hong Kong college students 显示文摘 | Moneta G B Siu C M Y | 2002 | Journal of College Student Development2002，43，5： | 1 |
| 8 | Opportunism as the inhibiting trigger for develo- ping long-term-oriented western exporter Hong Kong importer relationships 显示文摘 | Barnes B R Leonidou L C Siu N Y M Leonidou C N | 2010 | Journal of International Marketing2010，18，2： | 1 |
| 9 | Trait intrinsic and extrinsic motiva-tions,academic performance,and creativity in Hong Kong collegestudents显示文摘 | MONETA G B SIU M Y | 2002 | Journal of College Student Development2002，43，5： | 1 |
| 10 | PAPR reduction of an OFDM signal by use of PTS with low computational com- plexity 显示文摘 | YANG L CHEN R S SIU Y M | 2006 | IEEE Transactions on Broadcasting2006，52，1： | 1 |
| 11 | MDM2 and MDMX bind and stabilize the p53 related protein p73显示文摘 | Ongkeko W M Wang X Q Siu W Y | 1999 | Curr Bid1999，9，15： | 1 |
| 12 | Environmental and nutritional factors which regulate population dynamics and toxin production in the dinoflagellate Alexandrium catenella 显示文摘 | SIU G K Y YOUNG M L C CHAN D K O | 1997 | Hydrobiologia1997，352，： | 1 |
| 13 | Impact of convergence on slope stability analysis and design 显示文摘 | Cheng Y M Lansivaare T Siu J | 2008 | Computers and Geotechincs2008，35，： | 1 |
| 14 | Impact of convergence on slope stability analysis and design显示文摘 | Cheng Y M Lansivaare T Siu J | 2008 | Computers and Geotechincs2008，35，： | 1 |
| 15 | Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways显示文摘 | SIU F M MAD L CHEUNG Y W et ol | 2008 | Proteomics2008，8，15： | 1 |
| 16 | An Investigation of Decision - Making Styles of Consumers in China 显示文摘 | Hiu Alice S Y Noel Y M Siu Charlie C L Wang Ludwig M K Chang | 2001 | The Journal of Consumer Affairs2001，35，2： | 1 |
| 17 | The Significance of Trust and Renqing in the Long-term Orientation of Chinese Business- to-business Relationships 显示文摘 | Wang C L Siu N Y M Barnes B R | 2008 | Industrial Marketing Management2008，37，7： | 1 |
| 18 | A Fuzzy Approach to Signal Detection显示文摘 | LEUNG S W MINETT J W SIU Y M | 2002 | IEEE Trans on Aerospace and Electronic Systems2002，38，1： | 1 |
| 19 | PAPR reduction of an OFDM signal by use of PTS with low computational complexity显示文摘 | YANG L CHEN R S SIU Y M | 2006 | IEEE Transactions on Broadcasting2006，52，1： | 1 |
| 20 | Uniform Estimates for the -equation on domains with piecewise smooth strictly pseud- oconvex boundaries显示文摘 | RANGE R M SIU Y T | 1973 | Math Ann1973，，206： | 1 |
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