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| 1 | Histone modifications and alcohol-induced liver disease:Are altered nutrients the missing link?显示文摘Alcoholism is a major health problem in the United States and worldwide,and alcohol remains the single most significant cause of liver-related diseases and deaths.Alcohol is known to influence nutritional status at many levels including nutrient intake,absorption,utilization,and excretion,and can lead to many nutritional disturbances and deficiencies.Nutrients can dramatically affect gene expression and alcohol-induced nutrient imbalance may be a major contributor to pathogenic gene expression in alcohol-induced liver disease(ALD).There is growing interest regarding epigenetic changes,including histone modifications that regulate gene expression during disease pathogenesis.Notably,modifications of core histones in the nucleosome regulate chromatin structure and DNA methylation,and control gene transcription.This review highlights the role of nutrient disturbances brought about during alcohol metabolism and their impact on epigenetic histone modifications that may contribute to ALD.The review is focused on four critical metabolites,namely,acetate,S-adenosylmethionine,nicotinamide adenine dinucleotide and zinc that are particularly relevant to alcohol metabolism and ALD. | Akshata Moghe Swati Joshi-Barve Smita Ghare Leila Gobejishvili Irina Kirpich Craig J McClain Shirish Barve | 2011 | World Journal of Gastroenterology2011，17，20： | 6 |
| 2 | Examining the Effects of Alternative Management Strategies on Landscape-scale Forest Patterns in Northeastern Minnesota Using LANDIS 显示文摘 | SMITA M LEE E F MALCOLM T J | 2004 | Ecological Modelling2004，，5： | 1 |
| 3 | Clearance of α-synuclein oligomeric intermediates via the lysosomal degradation pathway 显示文摘 | Lee H J Khoshaghideh F Patel smita | 2004 | J Neuroscience2004，24，8： | 1 |
| 4 | Polymorphisms in interferon regulatory factor 7 reduce interferon-α responses of plasmacytoid dendritic cells to HIV-1显示文摘 | Judy Chang Robert J Lindsay Smita Kulkarni Jeffrey D Lifson Mary Carrington Marcus Altfeld | 2011 | AIDS2011，，： | 1 |
| 5 | The Effect of nanoparticle shape on the photocarrier dynamics and photovoltaic device performance of poly(3 - hexylthiophene):CdSe nanoparticle bulk heterojunction solar cells显示文摘 | SMITA D REESE M O FERGUSON A J | 2010 | Advanced Functional Materials2010，20，16： | 1 |
| 6 | Effects influencing boar semen 显示文摘 | Smita| J | 2009 | Animal Reproduction Science2009，110，： | 1 |
| 7 | Embryonic stem cells differentiation substantiates thalidomide teratogenicity显示文摘 | Kesavan M Smita J Vilas W | 2012 | Toxicology Letters2012，211，： | 1 |
| 8 | Comparative acceptability study of the Reality female condom and the version 4 Reddy female condom in India显示文摘 | Smita J Neelam J D Souza YR | 2005 | Contraception2005，72，5： | 1 |
| 9 | Geochemical fractionation of heavy metals in sediments of the Tapi estuary 显示文摘 | Krupadam R J Smita P Wate S R | 2006 | Geochemical Journal2006，40，5： | 1 |
| 10 | Echocardiac features simulating hypertrophic obstructive cardiomyopathy in a patient with pheochromocytoma 显示文摘 | Smita R J Thomas B Wolfgang B | 2009 | Clin Res Cardiol2009，98，3： | 1 |
| 11 | Phase transfer cata- lysed synthesis of 3-phenylcoumarins 显示文摘 | Smita M Makrandi J K Grover S K | 1989 | Indian J Chem Sect B1989，28，9： | 1 |
| 12 | R&D on CoreSeismic Design显示文摘 | Iyoku T Smita J Ishihara M | 2004 | Nuclear Engineering and Design2004，233，： | 1 |
| 13 | The role of stem cells in cardiac regeneration显示文摘 | Smita A M van Vliet P Hassink R J | 2005 | J Cell Mol Med2005，9，1： | 1 |
| 14 | All- trans retinoic acid and basic fibroblast growth factor synergistically direct pluripotent human embryonic stem cells to extraembryonic lineages显示文摘 | Smita Jagtap Kesavan Meganathan Vilas Wagh Karthick Natarajan Jürgen Hescheler Agapios Sachinidis | 2012 | Stem Cell Research2012，，： | 1 |
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