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| 1 | 慢加急性肝衰竭进展显示文摘2017年3月Gut发表了Hernaez等的综述《慢加急性肝衰竭进展》[Hernaez R,solaE,MoreauR,eta1.Acute—on—chronicliver failure:anupdate.Gut.2017.66:541—553]。慢加急性肝功能衰竭(acute—on—chronicliver failure,ACLF)是一种发生在有基础慢性肝病或者代偿期肝硬化患者中的,以由不同类型的损害导致的急性的严重肝功能异常为特征的综合征,短期病死率高,预后与急性肝衰竭相似。目前有很多不同的定义标准,2009年亚太肝病研究协会(APASL)提出了ACLF的第1版共识,2014年进行了更新。 | 姚勤伟 欧阳颖 孟庆华 Hernaez R Solà E Moreau R | 2017 | 北京医学2017，39，9： | 6 |
| 2 | 文献快报(4):童年期不良经历与成年期生理损害的关系--1958年英国出生队列研究显示文摘适应负荷(allostatic load,AL)是一种衡量躯体受到长期压力时所导致生理损害程度的评价工具,这种损害可能部分是由于生命早期不良经历所致,因此这个指标通常可作为评价慢性应激暴露水平的生物标志物。Barboza Solís C等通过对童年期不良经历(adverse childhood experiences,ACEs)与中年期适应负荷关系的研究来进一步验证远期不良经历可导致生理功能损害的研究假设。该课题组利用1958年英国出生队列,其中女性3 782人,男性3 753人,共随访了7次。在儿童7岁、11岁和16岁时分别调查了童年期不良经历;在队列人群44岁时,采用神经内分泌系统、免疫与炎症系统、代谢系统、呼吸与心血管系统4个系统14个指标作为评价其适应负荷的可操作性指标,同时调查了健康行为、 | BARBOZA SOLíS C KELLY-IRVING M FANTIN R 苏普玉 | 2015 | 中国学校卫生2015，36，3： | 3 |
| 3 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 4 | Human cytomegalovirus DNA in plasma and serum speciems of renal transplant reciplents is highly fragmented显示文摘 | Boom R Sol CJ Schuurman T | 2002 | J Clin Microbiol2002，40，11： | 1 |
| 5 | Laparoscopic cholecystectomy for acute cholecystitis显示文摘 | Cirocchi R Del Sol A Morelli U | 2008 | G Chir2008，29，67： | 1 |
| 6 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R Sol C J Salimans M M | 1990 | J Clin Microbiol1990，28，3： | 1 |
| 7 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R Sol C J Salimans M M | 1990 | J Clin Microbiol1990，28，3： | 1 |
| 8 | Tubular and interstitial expression of ICAM-1 as a marker of renal injury in IgA nephropathy显示文摘 | Arrizabalaga P Solé M Abellana R | 2003 | Am J Nephrol2003，23，3： | 1 |
| 9 | Rapid and simple method for purification of nucleic acids 显示文摘 | Boom R Sol CJA Salimans MMM | 1990 | J Clin Microbiol1990，28，3： | 1 |
| 10 | Rapid and simple method for purification of nucleic acids显示文摘 | Sol CJ Salimans MM | 1990 | J Clin Microbiol1990，28，3： | 1 |
| 11 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 12 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R Sol C J Salimans M M | 1990 | J Cli Microbiol1990，28，3： | 1 |
| 13 | Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis显示文摘 | Rodrigues C M Sol S Castro R E | 2002 | J Lipid Res2002，43，6： | 1 |
| 14 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R C J A Sol M M M Salimans | 1990 | Journal of Clinical Microbiology1990，28，： | 1 |
| 15 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R Sol CJ Salimans MM | 1990 | J Clin Microbiol1990，28，3： | 1 |
| 16 | Rapid and simple methods for purification ofnucleic acid 显示文摘 | Boom R Sol C J A Salimans M M M | 1990 | J Clin Microbiol1990，28，： | 1 |
| 17 | Rapid and Simple Method for Purification of Nucleic Acids显示文摘 | Sol CJ Sallmans MM | 1990 | Journal of clinical microbiology1990，28，3： | 1 |
| 18 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R C J Sol M M Salimans | 1990 | J Clin Microbiol1990，28，： | 1 |
| 19 | Rapid and Simple Method for Purification of Nucleic Acids显示文摘 | Sol CJ Salimans M M | 1990 | J Clin Microbiol1990，28，： | 1 |
| 20 | The small-world of human lan- guage 显示文摘 | Ferrer R Cancho I Sol~ R V | 2001 | Proceedings of the Royal Society of London Series B Biological Science2001，268，1482： | 1 |
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