|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Long - term results of a randomized trial of surgery with or without preoperative chemotherapy in esophageal cancer 显示文摘 | Allum WH Stenning SP Bancewicz J | 2009 | J Clin Oncol2009，27，30： | 1 |
| 3 | Long - term results of a randomized trial of surgery with or without preoperative chemo- therapy in esophageal cancer 显示文摘 | Allum WH Stenning SP Bancewicz J | 2009 | J Clini Oncol2009，27，30： | 1 |
| 4 | Torque amplification of control moment gyros显示文摘 | Lappas V J Sten W H Undewood C I | | 0，，15： | 1 |
| 5 | High-dose versus conventional-dose chemotherapy as first-salvage treatment in patients with non-seminomatous germ-cell tumors:a matched-pair analysis显示文摘 | Beyer J Stenning S Gerl A | 2002 | Ann Oncol2002，13，4： | 1 |
| 6 | The role of calcium in the regeneration of opoptosis显示文摘 | Mc CONKEY D J STEN O | 1996 | J Leukoc Biol1996，599，3： | 1 |
| 7 | Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell Pool显示文摘 | Ewa Sitnicka David Bryder Kim Theilgaard-M?nch Natalija Buza-Vidas J?rgen Adolfsson Sten Eirik W Jacobsen | 2002 | Immunity2002，，4： | 1 |
| 8 | Erosion of Wind Turbine Blade Coatings-design and Analysis of Jet-based Laboratory Equipment for Performance Evalua- tion显示文摘 | ZHANG Shi-zhong KIM D J STEN N | 2015 | Progress in Organic Coatings2015，78，： | 1 |
| 9 | Upregulation of Flt3 Expression within the Bone Marrow Lin ? Sca1 + c-kit + Stem Cell Compartment Is Accompanied by Loss of Self-Renewal Capacity显示文摘 | J?rgen Adolfsson Ole Johan Borge David Bryder Kim Theilgaard-M?nch Ingbritt ?strand-Grundstr?m Ewa Sitnicka Yutaka Sasaki Sten E.W Jacobsen | 2001 | Immunity2001，，4： | 1 |
| 10 | Simultaneous monitoring of oil film thickness and temperature in fluid film bearings 显示文摘 | Sergei B Glavatskih a O sten Uusitalo a Daniel J Spohn b | 2001 | Tribology International2001，34，： | 1 |
| 11 | The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages显示文摘 | Miller LE Jüsten HP Scholmerich J | 2000 | FASEB J2000，14，13： | 1 |
| 12 | A comprehensive genetic map of the mouse genome 显示文摘 | Dietrick W F Miller J Sten N R | 1996 | Nature1996，380，： | 1 |
| 13 | Ground-glass opacity at CT:the ABCs显示文摘 | Collins J Sten EJ | 1997 | AJR1997，169，8： | 1 |
| 14 | PGC-1{alpha}mediates exercise-induced skeletal muscle VEGF expression in mice显示文摘 | Leick L Hel sten Y Fentz J | | 0，，： | 1 |
| 15 | Hypofractionated radiotherapy for poor prognosis malignant glioma:matched pair survival analysis with MRC controls显示文摘 | McAleese J J Stenning S P Ashley S | 2003 | Radiother Oncol2003，67，2： | 1 |
| 16 | Integration of plug-in hybrid electric vehicles in a regional wind-thermal power system显示文摘 | Lisa G Sten K Filip J | 2010 | Energy Policy2010，38，10： | 1 |
| 17 | The role of calcium in the regulation of apoptosis显示文摘 | David J McConkey Sten O | 1997 | BBS1997，239，： | 1 |
| 18 | Benchmarking combined biological phosphorus and nitrogen removal wastewater treatment processes 显示文摘 | KRIST V G STEN B J | 2004 | Control Engineering Practice2004，，12： | 1 |
| 19 | A short fractionation radiotherapy for poor prognosis patients with high-grade glioma显示文摘 | Ford J M Stenning S P Boote D J | 1997 | Clin Oncol1997，9，1： | 1 |
| 20 | A cognitive theory of graphical and 1inguistic reasoning::Logic and implementation显示文摘 | Stenning K Oberlande J | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员