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| 1 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | Effect of Intensive Inorganic Fertilizer Application on Microbial Properties in a Paddy Soil of Subtropical China显示文摘A field experiment with rice-rice rotation was conducted since 2002 in southeast China for investigating the response of soil microbial properties to intensive nitrogen fertilizer application.The tested soil was a subtropical paddy soil derived from Quaternary red clay.Differences between treatments existed in different application rates of urea when the experiment was designed.Urea was applied in five rates,i.e.,0,0.5,1,1.5,and 2 U,equivalent to 0,0.5,1,1.5,and 2 times the local average amount of urea application(900 kg urea ha-1 yr-1,equivalent to 414 kg N ha-1 yr-1).In 2007,soil total nitrogen,available nitrogen,and soil organic carbon contents were increased by 10.2-27.9,8.0-16.0,and 10.2-30.6%,respectively,in treatments with urea application rates of 0.5 to 2 U compared to control(0 U).Microbial biomass carbon and nitrogen were also increased by 3.1-30.8 and 1.3-13.9%,respectively,in treatments with urea application.Basal respiration in treatments with urea input were 9.4-29.1% higher than that in control.However,changes of bacterial functional diversity had different trends.Urea fertilization enhanced bacterial functional diversity until treatment of 1 U,but re-decreased it from treatment of 1.5 U.Principal components analysis indicated that there were intimate relationships among soil organic matter,nitrogen nutrient,microbial biomass,and respiration.Nevertheless,microbial diversity was related to soil moisture contents after urea application.We conclude here that the application of N fertilizer improved soil microbial biomass and respiratory activity.But,microbial diversity was reduced when excessive urea was applied in the tested paddy soil. | Klemens Ekschmitt Stephanie I J Holzhauer Sabine Rauch | 2011 | Agricultural Sciences in China2011，10，11： | 5 |
| 3 | Matrix metalloproteinase expression in tumor invasion and metastasis显示文摘 | Stephanie C Graeme I | 1999 | J Pathol1999，189，3： | 1 |
| 4 | Matrix metalloproteinase expression in tumor invasion and metastasis显示文摘 | Stephanie C Graeme I | 1999 | J Pathol1999，189，3： | 1 |
| 5 | A mouse lung tumor model of tobacco smoke carcinogenesis 显示文摘 | Witschi HP Espiritu I Stephanie TD | 2002 | Toxicol Sci2002，68，8： | 1 |
| 6 | Turonian o ceanic red beds in the Eastern Alps: Concepts for palaeocean- ographic changes in the Mediterranean Tethys显示文摘 | Stephanie N M Wagreich M Wendler I | 2007 | Palaeo geography Palaeoclimatology Palaeoecology2007，251，2： | 1 |
| 7 | Matrix metalloproteinase expression in tumor invasion and metastasis显示文摘 | Stephanie C Graeme I | 1999 | J Pathol1999，189，3： | 1 |
| 8 | Preferentia l chemotaxis of activated human CD4 + T cells by extracellular cyclophilin A显示文摘 | Jesse M Michael I B Stephanie LC | 2007 | J Leukoc Biol2007，82，9： | 1 |
| 9 | Herzog Prognostic signifi- cance and treatment implications of positive peritoneal cytology in endometrial adenocarcinoma:Unraveling a mystery显示文摘 | Stephanie L Wethington Nicanor I | 2009 | Gynecologic Oncology2009，115，： | 1 |
| 10 | Matrix metalloproteinase expression in tumor invasion andmetastasis显示文摘 | Stephanie C Graene I | 1999 | Jpathol1999，189，3： | 1 |
| 11 | Real-time forensic DNA analysis at a crime scene using a portable microchip analyzer显示文摘 | Liu P Stephanie H I Y Karin A C | 2008 | Forensic Sci Int Genet2008，2，4： | 1 |
| 12 | A mouse lung tumor model of tobacco smoke carcinogenesis显示文摘 | Witschi HP Espiritu I Stephanie T | 2002 | Toxicol Sci2002，68，： | 1 |
| 13 | A novel method for simulating smoldering propagation and its application to STAR (Self-sustaining Treatment for Active Remediation)显示文摘 | Macphee Stephanie L Gerhard Jason I Rein Guillermo | 2012 | Environmental Modelling & Software2012，，31： | 1 |
| 14 | Integrated Sample Cleanup-Capillary Eleetrophoresis Microehip for High-Performance Short Tandem Repeat Genetic Analysis显示文摘 | Stephanie H I Yeung Peng Liu | 2009 | Anal Chem2009，81，： | 1 |
| 15 | Matrix metalloproteinase expression in tumor invasion and metastasis显示文摘 | Stephanie C Graeme I | 1999 | J Pathol1999，189，3： | 1 |
| 16 | Microalgal bioma-rkers: a review of recent research developments 显示文摘 | Johnk V Stephanie M B Susan I B | 1998 | Organic Geochemistry1998，29，57： | 1 |
| 17 | Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury显示文摘 | Chinmoy Sarkar Zaorui Zhao Stephanie Aungst Boris Sabirzhanov Alan I Faden Marta M Lipinski | 2014 | Autophagy2014，，12： | 1 |
| 18 | Hypertonic Saline Worsens Infarct Volume After Transient Focal Ischemia in Rats 显示文摘 | Bhardwaj A Harukuni I Stephanie J | 2000 | Stroke2000，31，7： | 1 |
| 19 | Matrix metalloproteinase expression in tumor invasion and metastasis显示文摘 | Stephanie C Graeme I | 1999 | J Pathol1999，189，3： | 1 |
| 20 | Quantitative real-time PCR assay for determining transgene copy number in transformed plants 显示文摘 | David J I Sandra B Stephanie M | 2001 | Biotechniques2001，31，1： | 1 |
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