|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | Inflammation-associated microsatellite alterations:Mechanisms and significance in the prognosis of patients with colorectal cancer显示文摘Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair(MMR). About 15% of sporadic colorectal cancers(CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono-and di-nucleotide frameshifts to classify it as microsatellite instability-high(MSI-H) and hypermutated, and due to frameshifts at coding microsatellites generating neo-antigens, produce a robust protective immune response that can be enhanced with immune checkpoint blockade. More commonly, approximately 50% of sporadic nonMSI-H CRCs demonstrate frameshifts at di-and tetra-nucleotide microsatellites to classify it as MSIlow/elevated microsatellite alterations at selected tetranucleotide repeats(EMAST) as a result of functional somatic inactivation of the DNA MMR protein MSH3 via a nuclear-to-cytosolic displacement. The trigger for MSH3 displacement appears to be inflammation and/or oxidative stress, and unlike MSI-H CRC patients, patients with MSI-L/EMAST CRCs show poor prognosis. These inflammatory-associated microsatellite alterations are a consequence of the local tumor microenvironment, and in theory, if the microenvironment is manipulated to lower inflammation, the microsatellite alterations and MSH3 dysfunction should be corrected. Here we describe the mechanisms and significance of inflammatory-associated microsatellite alterations, and propose three areas to deeply explore the consequences and prevention of inflammation's effect upon the DNA MMR system. | Minoru Koi Stephanie S Tseng-Rogenski John M Carethers | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 7 |
| 3 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 4 | BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs显示文摘 | Raffaella Gozzelino Carme Sole Nuria Llecha Miguel F Segura Rana S Moubarak Victoria Iglesias-Guimarais M Jose Perez-Garcia Stephanie Reix Jisheng Zhang Nahuai Badiola Daniel Sanchis Jose Rodriguez-Alvarez Ramon Trullas Victor J Yuste Joan X Comella | 2008 | Cell Research2008，18，10： | 4 |
| 5 | Linking advertising and quantity decisions in the single-period inventory model显示文摘 | Khouja M Stephanie S R | 2003 | International Journal of Production Economics2003，86，： | 1 |
| 6 | Prenatal phenol and phthalate exposures and birth outcomes 显示文摘 | Mary S Stephanie M Gertrud S | 2008 | Environ Health Perspect2008，6，8： | 1 |
| 7 | Providing social support may be more beneficial than receiving it: Results from a prospective study of mortality显示文摘 | Stephanie L B Randolph M N Amiram D V Dylan M S | 2003 | Psychology Science2003，，4： | 1 |
| 8 | Plasma concentration of N-terminal pro-brain natriurtic peptide in control children from the neonatal to adolescent period and in children with congestive heart failure显示文摘 | Mir T Stephani S Eiselt M | 2002 | Pediatrics2002，110，6： | 1 |
| 9 | The Epidemiology of Sep- sis in the United States from 1979 through 2000 显示文摘 | Greg S David M Stephanie Eaton | 2003 | N Engl J Med2003，348，： | 1 |
| 10 | Antioxidant properties of aged garlic extract: an in vitro study incorporating human low density lipoprotein显示文摘 | Stephanie A Dillon Rajpal S Burmi Gordon M | 2003 | Life Sciences2003，7，： | 1 |
| 11 | Carolyn McNamara ; Badger,Sarah,“If you want me to treat you like an adult,starting acting like one!” Comparing the criteria that emerging adults and their parents have for adulthood显示文摘 | Nelson Larry J Padila-Walker Laura M Carroll Jason S Madsen Stephanie D Barry | 2007 | Journal of Family Psychology2007，21，4： | 1 |
| 12 | Calcium addition at the hubbard brook experimental forest increases the capacity forstress tolerance and carbon capture in red spruce trees during the cold season显示文摘 | PAUL G S RAKESH M STEPHANIE L | 2011 | Trees2011，25，6： | 1 |
| 13 | Turf grass establishment on various root zones显示文摘 | James A M H iranthi S Josh A H Lawson T J Stephanie L M | 2004 | USGA Green Section Record2004，42，4： | 1 |
| 14 | Data gathering algorithms in sensor networks using energy metrics显示文摘 | STEPHANIE L CAULIGI R KRISHNA M S | 2002 | IEEE Transactions on Parallel and Distributed Systems2002，13，9： | 1 |
| 15 | Temper- ature and photoperiod affect stress resistance traits in Drosophila melanogaster显示文摘 | STEPHANIE S B VANESSA K NEDA N M | 2014 | Physiological Entomology2014，39，3： | 1 |
| 16 | Nutrition survey in an elderly population following admission to a tertiary care hospital 显示文摘 | Nahid A Joseph M Stephanie S | 1999 | Canadian Med Assoc1999，161，5： | 1 |
| 17 | Barriers to hospice care and refer rals:survey of physicians' knowledge,attitudes,and perceptions in a health maintenance organization显示文摘 | Leslea B Kate S Stephanie M | | 0，，03： | 1 |
| 18 | Nucleotide requirements for CDX2 binding to the cis promoter element mediating intestine-specific expression of guanylyl cyclase C显示文摘 | Di Guglielmo M D Park J Stephanie S | 2001 | FEBS Letters2001，507，2： | 1 |
| 19 | An Analysis of the Predictive Validity of the New Ecological Paradigm Scale显示文摘 | Cordano M Stephanie A W Robert F S | 2003 | Journal of Environmental Education2003，，34： | 1 |
| 20 | Increased hypotha-lamic GPR54 signaling:A potential mechanism for initiation of puberty inprimates显示文摘 | MUHAMMAD S CLAUDIO M STEPHANIE B | 2005 | Proc Natl Acad Sci USA2005，102，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员