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| 1 | 亚太地区慢性乙型肝炎治疗共识(2012最新版)显示文摘自2008年至今,有大量关于慢性HBV感染的自然史和治疗的最新数据不断涌现。其中包括慢性HBV感染的无症状感染者,以社区为基础的队列研究,HBV基因型的作用,非药物诱导的自然HBV变异型毒株,无创性肝纤维化评估方法的应用,HBsAg定量在临床中的应用,更有效的新治疗药物和新治疗方案等等。来自亚太地区的专家审查和评估了相关数据,并共同商讨了近年来报道的最有意义的发现,基于此,对2008年版的亚太地区慢性乙型肝炎治疗共识进行修订,同时对2008年版治疗指南定义的关键词组进行了修订。修订后的指南包括以下几方面内容:一般治疗,肝纤维化评价适应证,何时开始治疗或停药,初始抗病毒治疗药物的选择,如何监测治疗中和治疗后的患者。关于特殊人群的治疗建议中包括了对妊娠妇女,已发生耐药,合并其他病毒感染,肝功能失代偿,接受免疫抑制治疗、化疗,肝移植或肝细胞癌患者的具体治疗建议。 | 廖运范 Jia-HorngKao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Wan-Long Chuang Laurentius A.Lesmana Jose D.Sollano Dong-Jin Suh Masao Omata 刘颖 徐莹 李芸 黄祖雄 樊蓉 李小溪 吕国涛 周彬 孙剑 侯金林 | 2012 | 临床肝胆病杂志2012，28，8： | 182 |
| 2 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update显示文摘 | Yun-Fan Liaw Jia-Horng Kao Teerha Piratvisuth Henry Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Jin-Lin Hou Wan-Long Chuang Laurentius Lesmana Jose | 2012 | Hepatology International2012，，3： | 6 |
| 3 | Global research trends in the microbiome related to irritable bowel syndrome: A bibliometric and visualized study显示文摘BACKGROUND Irritable bowel syndrome(IBS) is a common functional gastrointestinal disorder. Dysregulation of the gut–brain axis plays a central role in the pathophysiology of IBS. It is increasingly clear that the microbiome plays a key role in the development and normal functioning of the gut–brain axis.AIM To facilitate the identification of specific areas of focus that may be of relevance to future research. This study represents a bibliometric analysis of the literature pertaining to the microbiome in IBS to understand the development of this field.METHODS The data used in our bibliometric analysis were retrieved from the Scopus database. The terms related to IBS and microbiome were searched in titles or abstracts within the period of 2000–2019. VOSviewer software was used for data visualization.RESULTS A total of 13055 documents related to IBS were retrieved at the global level. There were 1872 scientific publications focused on the microbiome in IBS. There was a strong positive correlation between publication productivity related to IBS in all fields and productivity related to the microbiome in IBS(r = 0.951, P < 0.001). The United States was the most prolific country with 449(24%) publications, followed by the United Kingdom(n = 176, 9.4%), China(n = 154, 8.2%), and Italy(n = 151, 8.1%). The h-index for all retrieved publications related to the microbiome in IBS was 138. The hot topics were stratified into four clusters:(1) The gut–brain axis related to IBS;(2) Clinical trials related to IBS and the microbiome;(3) Drugmediated manipulation of the gut microbiome;and(4) The role of the altered composition of intestinal microbiota in IBS prevention.CONCLUSION This is the first study to evaluate and quantify global research productivity pertaining to the microbiome in IBS. The number of publications regarding the gut microbiota in IBS has continuously grown since 2013. This finding suggests that the future outlook for interventions targeting the gut microbiota in IBS remains promising. | Sa'ed H Zyoud Simon Smale W Stephen Waring Waleed Sweileh Samah W Al-Jabi | 2021 | World Journal of Gastroenterology2021，27，13： | 2 |
| 4 | Erratum to: Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update显示文摘 | Yun-Fan Liaw Jia-Horng Kao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Jin-Lin Hou Wan-Long Chuang Laurentius A. | 2012 | Hepatology International2012，，4： | 2 |
| 5 | A comprehensive catalogue of somatic mutations from a human cancer genome显示文摘 | Pleasance ED Cheetham RK Stephens PJ | 2010 | Nature2010，463，7278： | 1 |
| 6 | Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing显示文摘 | Campbell PJ Stephens PJ Pleasance ED | 2008 | Nat Genet2008，40，6： | 1 |
| 7 | Identification of somatically acquired rearrangements in cancer using genomewide massively parallel paired-end sequencing 显示文摘 | Campbell PJ Stephens PJ Pleasance ED | 2008 | Nat Genet2008，40，6： | 1 |
| 8 | Changes in distribution, cell associations and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin - c during acute to chronic maturation of spinal cord scar tissue 显示文摘 | Xiufeng T Jeannette ED Stephen JAD | 2003 | J Neurosci Res2003，71，： | 1 |
| 9 | Classification,identification,and assessment of surgical treatment of anorectal anomalies显示文摘 | Smith ED | 1986 | Pediatr Surg Int1986，1，： | 1 |
| 10 | SARS, emerging infections, and bioterrorism preparedness 显示文摘 | Stephen G Weber Ed Bottei Richard Cook | 2004 | The Lancet Infectious Diseases2004，，8： | 1 |
| 11 | Optimal annual routines: New tools forconservation biology? 显示文摘 | Fer6 O Stephens P A Barta Z Parkhurst D F (Ed) | 2008 | Ecological Applications2008，18，6： | 1 |
| 12 | Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing显示文摘 | Campbell PJ Stephens PJ Pleasance ED | 2008 | Nat Genet2008，0，： | 1 |
| 13 | Effects of cyclophosphamide on murinecandidiasis显示文摘 | Stephen AM Judith ED | 1980 | Infect Immunity1980，27，： | 1 |
| 14 | A small-cell lung cancer genome with complex signatures of tobacco exposure显示文摘 | Pleasance ED Stephens PJ O'Meara S | 2010 | Nature2010，463，： | 1 |
| 15 | A small-cell lung cancer genome with complex signatures of tobacco exposure显示文摘 | Pleasance ED Stephens PJ O'Mearas S | 2010 | Nature2010，463，7278： | 1 |
| 16 | A comprehensive catalogue of somatic mutations from a human cancer genorne显示文摘 | Pleasance ED Cheetham RK Stephens PJ | 2010 | Nature2010，463，7278： | 1 |
| 17 | Physical characterization of enzymatically modified kraft pulp fibers显示文摘 | Mansfield Shawn 0 Jong Ed de Stephens R Scott | 1997 | Journal of Biotechnology1997，，57： | 1 |
| 18 | Identification of so- matically acquired rearrangements in cancer using genome-wide mas- sively parallel paired-end sequencing显示文摘 | Campbell PJ Stephens PJ Pleasance ED | 2008 | Nat Genet2008，40，6： | 1 |
| 19 | Physical characterization of enzymatically modified kraft pulpfibers显示文摘 | Mansfield Shawn D Jong ED de Stephens R Scott | 1997 | Joural of Biotechnology1997，57，： | 1 |
| 20 | High throughput DNA sequence variant detection by conformation sensitive capillary electrophoresis and automated peak comparison显示文摘 | Helen Davies Ed Dicks Philip Stephens Charles Cox Jon Teague Chris Greenman Graham Bignell Sarah O’Meara Sarah Edkins Adrian Parker Claire Stevens Andrew Menzies Matt Blow Bill Bottomley Mark Dronsfield P. Andrew Futreal Michael R. Stratton Richard Wooste | 2005 | Genomics2005，，3： | 1 |
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