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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 3 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | The Lancet2012，，9814： | 2 |
| 4 | Mutations of the BRAF gene in human cancer显示文摘 | Davies H Bignell G R Cox C Stephens P Edkins S Clegg S et al | 2002 | Nature2002，417，： | 1 |
| 5 | Morphology, genesis, and distribution of nanometer-scale pores in siliceous mudstones of the Mississippian Barnett shale显示文摘 | Robert G L Robert M R Stephen C R | 2009 | Journal of Sedimentary Research2009，79，12： | 1 |
| 6 | Repopu- lation of gamma-irradiated Lewis lung carcinoma by malig- nant cells and host macrophage progenitors显示文摘 | STEPHENS T C CURRIE G A PEACOCK J H | 1978 | Br J Cancer1978，38，5： | 1 |
| 7 | Chemokine receptors CCR6 and CXCR3 are necessary for CD4 + T cell mediated ocular surface disease in experimen- tal dry eye disease显示文摘 | TERRY G NIRAL B EUGENE A STEPHEN C CINTIA S | 2013 | PLoS One2013，8，78： | 1 |
| 8 | Synthesis of dipotassium dimethylsilanediolate monohydrate 显示文摘 | Stephen C Janis G M Michael J O | 2002 | Silicone Chemistry2002，，1： | 1 |
| 9 | Transgenic pigs as bioreactors: a comparison ofgamma-carboxylation of glutamic acid in recombinant humanprotein C and factor Ⅸ by the mammary gland显示文摘 | KEVIN E V C STEPHEN P B CHRISTOPHER G R | 1999 | Genetic Analysis: Biomolecular Engineering1999，15，： | 1 |
| 10 | Morphology, genesis, and distribution of nanometer-scale pores in siliceous mudstones of the Mississippian Barnett shale显示文摘 | Robert G L Robert M R Stephen C R | 2009 | Journal of Sedimentary Research2009，79，12： | 1 |
| 11 | Dice with fair sums显示文摘 | LEWIS C Robertson RAE Michael Shortt STEPHEN G Landry | 1998 | The American Mathematical Monthly1998，95，4： | 1 |
| 12 | Morphology genesis and distribution of nanometer-scalepores in siliceous mudstones of the Mississippian BarnettShale 显示文摘 | ROBERT G L ROBERT M R STEPHEN C R | 2009 | Journal of Sedimentary Research2009，，79： | 1 |
| 13 | Investigation of benzene oxide in bone marrow and other tissues of F344 rats following metabolism of benzene in vitro and in vivo 显示文摘 | Andrew B L Karen YO C Suramya W Thomas A M Bernard T G Stephen M R | 1998 | Chemical Research in Toxicology1998，11，4： | 1 |
| 14 | Functional motor neurons differentiating from mouse multipotent spinal cord precursor cells in culture and after transplantation into transected sciatic nerve 显示文摘 | Stephen C Ian G Shawn H | 2003 | J Neurosurg2003，98，： | 1 |
| 15 | A multi-echelon inventory model for a repairable item with one-for-one replenishment 显示文摘 | Stephen C G | 1985 | Management Science1985，31，10： | 1 |
| 16 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 17 | A combined corner and edge detector显示文摘 | Harris C G Stephens M Harris C G | 1988 | Proc of Fourth Alvey Vision Conference1988，53，3： | 1 |
| 18 | Morphology,Genesis, and Distribution of Nanometer -scale Pores inSiliceous Mudstones of the Mississippian Bamett Shale 显示文摘 | Robert G L Robert M R Stephen C R | 2009 | Journal of Sedimentary Research2009，79，12： | 1 |
| 19 | Application of the HilbertHuang Transform to the Analysis of Molecular Dynamics Simulations显示文摘 | Stephen C P Robert J G Jonathan W E | | 0，，： | 1 |
| 20 | Lung cancer: intragenic ERBB2 kinase mutations in turnouts 显示文摘 | Stephens P Hunter C Bignell G | 2004 | Nature2004，431，7008： | 1 |
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