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| 1 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 2 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 3 | Kinetics and mechanisms of the low-temperature degradation of cellulose显示文摘 | Emsley A M Stevens G C | 1994 | Cellulose1994，1，1： | 1 |
| 4 | Serum cystatin C is superior toserum creatinine as a marker of kidney function:a meta-analysis显示文摘 | Dharnidharka VR Kwon C Stevens G | 2002 | Am J Kidney Dis2002，40，2： | 1 |
| 5 | Surface modification of polymer surfaces: atmospheric plasma versus vacuum plasma treatments 显示文摘 | Shenton M J Stevens G C | 2001 | Journal of Physics D: Applied Physics2001，34，4： | 1 |
| 6 | Serum cystatin C is superior to serum creatinine as a marker of kidney function:a meta-analysis显示文摘 | KWON C STEVENS G | 2002 | Am J Kidney Dis2002，40，2： | 1 |
| 7 | Review of chemical of degradation of cellulosic electrical paper in oil-filled transformers显示文摘 | Emsley A indicators insulation M Stevens G C | 1994 | IEE Proceedings-Science Measurement Technology1994，141，5： | 1 |
| 8 | Serum cystatin C is superi- or to serum creatinine as a marker of kidney function : a meta-analy- sis显示文摘 | Dharnidharka VR Kwon C Stevens G | 2002 | Am J Kidney Dis2002，40，： | 1 |
| 9 | Integrating the Supply Chain 显示文摘 | Stevens G C | 1989 | International Journal of Physical Distribution and Materials Management1989，，8： | 1 |
| 10 | Characterization of the microbial diversity in a permafrost sample from the Canadian high Arctic using culture-dependent and culture-independent methods显示文摘 | STEVEN B BRIGGS G MCKAY C P | 2007 | FEMS Microbiology Ecology2007，59，2： | 1 |
| 11 | Higher rates of autism and attention deficit/hyperactivity disorder in American children:Are food quality issues impacting epigenetic inheritance?显示文摘In the United States,schools offer special education services to children who are diagnosed with a learning or neurodevelopmental disorder and have difficulty meeting their learning goals.Pediatricians may play a key role in helping children access special education services.The number of children ages 6-21 in the United States receiving special education services increased 10.4%from 2006 to 2021.Children receiving special education services under the autism category increased 242%during the same period.The demand for special education services for children under the developmental delay and other health impaired categories increased by 184%and 83%respectively.Although student enrollment in American schools has remained stable since 2006,the percentage distribution of children receiving special education services nearly tripled for the autism category and quadrupled for the developmental delay category by 2021.Allowable heavy metal residues remain persistent in the American food supply due to food ingredient manufacturing processes.Numerous clinical trial data indicate heavy metal exposures and poor diet are the primary epigenetic factors responsible for the autism and attention deficit hyperactivity disorder epidemics.Dietary heavy metal exposures,especially inorganic mercury and lead may impact gene behavior across generations.In 2021,the United States Congress found heavy metal residues problematic in the American food supply but took no legislative action.Mandatory health warning labels on select foods may be the only way to reduce dietary heavy metal exposures and improve child learning across generations. | Renee J Dufault Raquel A Crider Richard C Deth Roseanne Schnoll Steven G Gilbert Walter J Lukiw Amanda L Hitt | 2023 | World Journal of Clinical Pediatrics2023，12，2： | 1 |
| 12 | Immune and pathologic responses in mice infected with Brucella abortus 19, RB51, or 2308 显示文摘 | Stevens M G Olsen S C Pugh G W | 1994 | Infec Immunity1994，62，： | 1 |
| 13 | MinimaLLy invasive surgery for uroLogic disease in chiLdren显示文摘 | DanieLLe D Sweeney Marc C SmaLdone and Steven G Docimo | 2007 | NATURE CLINICAL PRACTICE2007，4，： | 1 |
| 14 | Perparation of diafenthiuron, the correspoding carbodiimide 显示文摘 | C L Stevens G H Singhal | 1967 | J Org Chem1967，32，9： | 1 |
| 15 | The latitudinal gradient in species range: How so many species coexist in the tropics?显示文摘 | STEVENS G C | 1989 | American Naturalist1989，133，： | 1 |
| 16 | Review of Chemical Indicators of Degradation of Cellulosic Electrical Paper Insulation in Oil-filled Transformers显示文摘 | Emsley A M Stevens G C | 1994 | lEE Proceedings of Science Mea- surement and Technology1994，141，5： | 1 |
| 17 | Surface modification of polymer surfaces:atmospheric plasma versus vacuum plasma treatments显示文摘 | SHENTON M J STEVENS G C | 2001 | Journal of Physics D-Applied Physics2001，34，18： | 1 |
| 18 | Comparison of immune responses and resistance to Brucellosis in mice vaccinated with Brucella abortus 19 or RB51 显示文摘 | Stevens M G Olsen S C Pugh G W | 1995 | Infect Immun1995，63，： | 1 |
| 19 | NMR of biofluids and pattern recognition: assessing the impact of NMR parameters on the principal component analysis of urine from rat and mouse显示文摘 | Potts B C M Deese A J Stevens G J | 2001 | J Pharm Biomed Anal2001，26，3： | 1 |
| 20 | Serum cystatin C is superior to serum creatinine as a marker of kidney function:a meta-anatysis 显示文摘 | Dharnidharka VR Kwon C Stevens G | 2002 | Am J Kidney Dis2002，40，2： | 1 |
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