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| 1 | Treatment of hepatitis B virus infection in children and adolescents显示文摘Hepatitis B virus(HBV)infection is one of the main causes of morbidity and mortality worldwide.Most children acquire the infection perinatally or during early childhood and develop a chronic hepatitis characterized by a high viral replication and a low-inflammation phase of infection,with normal or only slightly raised aminotransferases.Although a conservative approach in children is usually recommended,different therapies exist and different therapeutic approaches are possible.The main goals of antiviral treatment for children with chronic HBV infection are to suppress viral replication and to warn the disease progression to cirrhosis and hepatocellular carcinoma,although these complications are rare in children.Both United States Food and Drug Administration(USFDA)and European Medicines Agency(EMA)have approved interferon alfa-2b for children aged 1 year and older,pegylated interferon alfa-2a and lamivudine for children aged 3 years and older,entecavir for use in children aged 2 years and older,and adefovir for use in those 12 years of age and older.Tenofovir disoproxil fumarate is approved by EMA for children aged 2 years and older and by USFDA for treatment in children aged 12 years and older.Finally,EMA has approved the use of tenofovir alafenamide for treatment of children aged 12 years and older or for children weighing more than 35 kg independent of age.This narrative review will provide the framework for summarizing indications to antiviral therapy in the management of chronic HBV infection in children and adolescents. | Mariangela Stinco Chiara Rubino Sandra Trapani Giuseppe Indolfi | 2021 | World Journal of Gastroenterology2021，27，36： | 5 |
| 2 | Immunohistochemical evaluation of vitamin D receptor(VDR) expression in cutaneous melanoma tissues and four VDR gene polymorphisms显示文摘Objective:Vitamin D receptor(VDR)mediates vitamin D activity.We examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)polymorphisms.Methods:We evaluated VDR protein expression(by monoclonal antibody immunostaining),melanoma characteristics,and carriage of VDR-Fok I-rs2228570(C>T),VDR-Bsm I-rs1544410(G>A),VDR-ApaI-rs7975232(T>G),and VDR-TaqI-rs731236(T>C)polymorphisms(by restriction fragment length polymorphism).Absence or presence of restriction site was denoted by a capital or lower letter,respectively:'F'and'f'for Fok I,'B'and'b'for Bsm I,'A'and'a'for ApaI,and 'T'and't'for TaqI endonuclease.Seventy-four Italian cutaneous primary melanomas(52.1±12.7 years old)were studied;51.4% were stage Ⅰ,21.6% stage Ⅱ ,13.5% stage Ⅲ,and 13.5% stage Ⅳ melanomas.VDR expression was categorized as follows:100% positive vs.<100%;over the median 20%(high VDR expression)vs.≤20%(low VDR expression);absence vs.presence of VDR-expressing cells.Results:Stage I melanomas,Breslow thickness of<1.00 mm,level II Clark invasion,Aa heterozygous genotype,and AaTT combined genotype were more frequent in melanomas with high vs.low VDR expression.Combined genotypes BbAA,bbAa,AATt,BbAATt,and bbAaTT were more frequent in 100%vs.<100%VDR-expressing cells.Combined genotype AATT was more frequent in melanomas lacking VDR expression(odds ratio=14.5;P=0.025).VDR expression was not associated with metastasis,ulceration,mitosis>1,regression,tumor-infiltrating lymphocytes,tumoral infiltration of vascular tissues,additional skin and non-skin cancers,and melanoma familiarity.Conclusions:We highlighted that VDR polymorphisms can affect VDR expression in excised melanoma cells.Low VDR expression in AATT carriers is a new finding that merits further study.VDR expression possibly poses implications for vitamin D supplementation against melanoma.VDR expression and VDR genotype may become precise medicinal tools for melanoma in the future. | Francesco La Marra Giuseppe Stinco Cinzia Buligan Giovanni Chiriacò Diego Serraino Carla Di Loreto Sabina Cauci | 2017 | Cancer Biology & Medicine2017，14，2： | 5 |
| 3 | Bsm I(rs1544410) and Fok I(rs2228570) vitamin D receptor polymorphisms, smoking, and body mass index as risk factors of cutaneous malignant melanoma in northeast Italy显示文摘Objective:To investigate whether vitamin D receptor gene(VDR)Bsm I-rs1544410 and Fok I-rs2228570 polymorphisms,smoking duration,and body mass index(BMI)are risk factors for cutaneous melanoma,especially metastatic melanoma.Methods:We studied 120 cutaneous melanoma cases[68 stage I and II non-metastatic melanoma(NMet M)patients,plus 52Stage III and IV metastatic melanoma(Met M)patients],and 120 matching healthy controls from northeast Italy.VDR polymorphisms were measured by restriction fragment length polymorphism analysis.Absence or presence of Bsm I and Fok I restriction sites was denoted by'B'and'F'or by'b'and'f,'respectively.Results:VDR-Bsm I bb genotype was more frequent among Met M(32.7%)than among NMet M cases(13.2%),with odds ratio(OR)=3.18.Comparison of all melanoma patients vs healthy controls showed that the following biomarkers were at risk:≥20 years of smoking(OR=2.43);≥20 years of smoking combined with bb(OR=4.78),Bb+bb(OR=2.30),Ff(OR=3.04),and Ff+ff(OR=3.08);obesity(BMI>30Conclusions:Risk factors for cutaneous Met M include two VDR polymorphisms combined with smoking duration and obesity.Results suggest gene-environment implications in melanoma susceptibility and severity.Future studies in larger cohorts and in subjects with different genetic background are warranted to extend our findings. | Sabina Cauci Vincenzo Maione Cinzia Buligan Martina Linussio Diego Serraino Giuseppe Stinco | 2017 | Cancer Biology & Medicine2017，14，3： | 3 |
| 4 | Lycopene isomers in fresh and processed tomato products: Correla- tions with instrumental color measurements by digital image analysis and spectroradiometry显示文摘 | STINCO C M RODRIGUEZ-PULIDO F J ESCUDERO-GILETE M L | 2013 | Food Res Int2013，50，1： | 1 |
| 5 | Free Radical Scavenging Properties of Phytofluene and Phytoene Isomers as Compared to Lycopene:A Combined Experimental and Theoretical Study显示文摘 | Martínez A Stinco C M Melendez-Martínez A J | 2014 | J Phys Chem B2014，118，33： | 1 |
| 6 | FOLFIRI + bevacizumab as second-line therapy for metastatic colorectal cancer pretreated with oxaliplatin: a pooled analysis of publishied trial显示文摘 | Beretta GD Petrelli F Stinco S et a1 | 2013 | Med Oncol2013，30，1： | 1 |
| 7 | Impact of Sea Clutter Non-stationary on Disturbance Covariance Matrix Estimation and CFAR Detector Performance 显示文摘 | Greco M Stinco P Gini F | 2010 | IEEE Transactions on Aerospace and Electronic Systems2010，46，3： | 1 |
| 8 | Complications of pseudoainhum显示文摘 | Stinco G Quinkenstein E | 2003 | Hautarzt2003，54，2： | 1 |
| 9 | Identification and analysisof sea radar clutter spikes显示文摘 | GRECO M STINCO P GINI F | 2010 | IET Radar Sonar Navigation2010，4，2： | 1 |
| 10 | Erythrodermic psoria- sis: current and future role of biological 显示文摘 | Stinco G Errichetti E | 2015 | BioDrugs2015，29，2： | 1 |
| 11 | Identification and analysis of sea radar clutter spikes显示文摘 | Greco M Stinco P and Gini F | 2010 | IET Radar Sonar & Navigation2010，4，2： | 1 |
| 12 | An open random-ized study to compare narrow band UVB, topical pimecroli- mus and topical tacrolimus in the treatment of vitiligo 显示文摘 | G Stinco F Piceirillo M Forcione | 2009 | Eur J Dermatol2009，19，6： | 1 |
| 13 | Muhiple sclerosis and bulous pemphigoid: a casual association or a pathogenetic correlation? 显示文摘 | Stinco G Mattighelo P Zanchi M | 2002 | Eur Dermato12002，12，2： | 1 |
| 14 | Visual and instrumental evaluation of orange juice color:AConsumers’preference Study显示文摘 | Fernández-Vázquez R Stinco C M Meléndez-Martínez A J | 2011 | Journal of sensory studies2011，26，6： | 1 |
| 15 | Cramer-Rao Bounds and selection of bistatic channels for multistatic radar systems显示文摘 | Greco M Stinco P Gini F | 2011 | IEEE Transactions on Aerospace and Electronic Systems2011，47，4： | 1 |
| 16 | Children and sun exposure in the northeast of Italy显示文摘 | STINCO G FAVOT F QUINKENSTEIN E | | 0，，06： | 1 |
| 17 | Study of the partners of women with human papillomavirus infection 显示文摘 | Kokelj F Baragginoo E Stinco G | 1993 | International Journal of Dermatology1993，32，： | 1 |
| 18 | Posterior Cram6r-Rao lower bounds for passive bistatic radar tracking with uncertain target measurements 显示文摘 | STINCO P GRECO M GINI F FARINA A | 2013 | Signal Processing2013，93，12： | 1 |
| 19 | A retrospective epidemi- ological study on the association of bullouspemphigoid and neu- rological diseases显示文摘 | Stinco G Codutti R Scarbolo M | 2005 | Acta Derm Venereol2005，85，2： | 1 |
| 20 | Cram6r-Rao bounds and selection of bistatic channels for multistatic radar systems 显示文摘 | GRECO M STINCO P GINI F FARINA A | 2011 | IEEE Transactions on Aerospace and Electronic Systems2011，47，29： | 1 |
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