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| 1 | Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients:a crossover design study显示文摘A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of stroke.Thus,strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these patients.Physical exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different populations.However,little is reported on this in post-stroke patients.The purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation(FES)on cognitive performance,clinical functional parameters,oxidative stress and epigenetic modulation in post-stroke individuals.In this crossover design study,12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes)without WalkAide functional electrical stimulation(EXE alone group),followed by another single session of exercise(45 minutes)with WalkAide functional electrical stimulation(EXE+FES group).The clinical functional outcome measures,cognitive performance and blood collections for biomarker measurements were assessed pre-and post-intervention.After intervention,higher Berg Balance Scale scores were obtained in the EXE+FES group than in the EXE alone group.There was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE+FES groups.After intervention,a better cognitive performance was found in both groups compared with before the intervention.After intervention,the Timed Up and Go test scores were higher in the EXE+FES group than in the EXE alone group.In addition,the intervention induced lower levels of lipid peroxidation.After intervention,carbonyl level was lower,superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE+FES group,compared with the EXE group alone.In each group,both histone deacetylase(HDAC2)and histone acetyltransferase activities were increased after intervention compared with before the intervention.These findings suggest that a single exercise session with WalkAide FES is more effective on balance ability and cognitive performance compared with conventional exercise alone in post-stroke patients.This is likely to be related to the regulation of oxidative stress markers.The present study was approved by the Research Ethics Committee of the Methodist University Center-IPA(approval No.2.423.376)on December 7,2017 and registered in the Brazilian Registry of Clinical Trials—ReBEC(RBR-9phj2q)on February 11,2019. | Viviane Rostirola Elsner Lucieli Trevizol Isadora de Leon Marcos da Silva ThaynáWeiss Milena Braga Daniela Pochmann Amanda Stolzenberg Blembeel Caroline Dani Elenice Boggio | 2021 | Neural Regeneration Research2021，16，5： | 3 |
| 2 | Epithelial antibiotics induced at sites of inflammation显示文摘 | Schonwetter BS Stolzenberg ED Zasloff MA | 1995 | Science1995，267，： | 2 |
| 3 | Sexual practices and sexual satisfaction:a population based study of Chinese urban adults显示文摘 | PARISH W L LUO Ye STOLZENBERG R | 2007 | Archives of Sexual Behavior2007，36，1： | 1 |
| 4 | The measurement and decomposi?tion of causal effects in nonlinear and nonadditive models显示文摘 | Stolzenberg R M | 1980 | Sociological Methodology1980，，11： | 1 |
| 5 | Beyond the magnet award: The ANCC magnet program as the framewok for culture change显示文摘 | Stolzenberger KM | 2003 | Nursing Administration2003，33，10： | 1 |
| 6 | Experimentally cross-wired lingual taste nerves can restore normal unconditioned gaping behavior in response to quinine stimulation显示文摘 | King CT Garcea M Stolzenberg DS | 2008 | Am J Physiol Regul Integr Comp Physiol2008，294，3： | 1 |
| 7 | Epithelial antibiotics induced at sites of inflammation 显示文摘 | Schonwetter BS Stolzenberg ED Zasloff MA | 1995 | Science1995，267，5204： | 1 |
| 8 | Reduction of cor-onary heart disease risk factors in the German cardiovascular pre-vention study显示文摘 | Hoffmeister H Mensink GB Stolzenberg H | 1996 | Prev Med1996，25，2： | 1 |
| 9 | Genome wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer显示文摘 | Amundadottir L Kraft P Stolzenberg Solomon RZ | 2009 | Nat Genet2009，41，9： | 1 |
| 10 | Reduction of coronary heart disease risk factors in the German cardiovascular prevention study显示文摘 | Hoffrneister H Mensink GB Stolzenberg H | 1996 | Prev Med1996，25，2： | 1 |
| 11 | Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis显示文摘 | Anderson GM Stolzenberg ED | 1997 | Cell1997，88，4： | 1 |
| 12 | Reduction of coronary heart disease risk factors in the German Cardiovascular Prevention Study 显示文摘 | Hiffmeister H mensink GBM Stolzenberg H | 1996 | Pre MED1996，25，： | 1 |
| 13 | Human β-defensin-1 is s salt-senitive antibiotic in lung that is inactived in cystic fibrosis显示文摘 | Goldman MJ Anderson GM Stolzenberg ED | 1997 | Cell1997，88，4： | 1 |
| 14 | Epithelial antibiotics induced at sites of inflammation 显示文摘 | Schonwetter BS Stolzenberg ED Zasloff MA | 1995 | Science1995，267，5204： | 1 |
| 15 | Epithelial antibiotics induced at sites of inflammation显示文摘 | Schonwetter BS Stolzenberg ED Zasloff MA | 1995 | Science1995，267，5204： | 1 |
| 16 | Dietary and other methyl grip availability factors and pancreatic cancer risks in a cohort of male smokers 显示文摘 | Stolzenberg - Solomon RZ Pietinen Pa Barren MJa | 2001 | Am J Epidemiol2001，153，： | 1 |
| 17 | Epithelial antibiotic induced in states of disease 显示文摘 | Anderson G M Acker- mann M R | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 18 | Epithelial antibiotics induced at sites of inflammation 显示文摘 | Sxhonwetter B S Stolzenberg E D Zaslo M A | 1995 | Science1995，267，： | 1 |
| 19 | Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis显示文摘 | Goldman MJ Andenson GM Stolzenberg ED | 1997 | Cell1997，88，8： | 1 |
| 20 | Beyond the magnet award: the ANCC magnet program as the framework for culture change显示文摘 | Stolzenberger Kathleen M | 2003 | Nursing administration2003，33，10： | 1 |
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