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| 1 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 2 | The role of antioxidants and pro-oxidants in colon cancer显示文摘This review focuses on the roles antioxidants and prooxidants in colorectal cancer(CRC).Considerable evidence suggests that environmental factors play key roles in the incidence of sporadic CRC.If pro-oxidant factors play an etiological role in CRC it is reasonable to expect causal interconnections between the wellcharacterized risk factors for CRC,oxidative stress and genotoxicity.Cigarette smoking,a high dietary consumption of n-6 polyunsaturated fatty acids and alcohol intake are all associated with increased CRC risk.These risk factors are all pro-oxidant stressors and their connections to oxidative stress,the intestinal microbiome,intestinal microfold cells,cyclooxygenase-2 and CRCare detailed in this review.While a strong case can be made for pro-oxidant stressors in causing CRC,the role of food antioxidants in preventing CRC is less certain.It is clear that not every micronutrient with antioxidant activity can prevent CRC.It is plausible,however,that the optimal food antioxidants for preventing CRC have not yet been critically evaluated.Increasing evidence suggests that RRR-gamma-tocopherol(the primary dietary form of vitamin E)or other'non-alpha-tocopherol'forms of vitamin E(e.g.,tocotrienols)might be effective.Aspirin is an antioxidant and its consumption is linked to a decreased risk of CRC. | William L Stone Koyamangalath Krishnan Sharon E Campbell Victoria E Palau | 2014 | World Journal of Gastrointestinal Oncology2014，6，3： | 4 |
| 3 | Emergency department patients with small bowel obstruction: What is the anticipated clinical course?显示文摘BACKGROUND:Emergency physicians(EPs)often care for patients with acute small bowel obstruction.While some patients require exploratory laparotomy,others are managed successfully with supportive care.We aimed to determine features that predict the need for operative management in emergency department(ED)patients with small bowel obstruction(SBO).METHODS:We performed a retrospective chart review of 370 consecutive patients admitted to a large urban academic teaching hospital with a diagnosis of SBO over a two-year period.We evaluated demographic characters(prior SBO,prior abdominal surgery,active malignancy)and clinical findings(leukocytosis and lactic acid)to determine features associated with the need for urgent operative intervention.RESULTS:Patients with a prior SBO were less likely to undergo operative intervention[20.3%(42/207)]compared to those without a prior SBO[35.2%(57/162)].Abnormal bloodwork was not associated with need for operative intervention.68%of patients with CT scan findings of both an SBO and a hernia,however,were operatively managed.CONCLUSIONS:Patients with a history of SBO were less likely to require operative intervention at any point during their hospitalization.Abnormal bloodwork was not associated with operative intervention.The CT finding of a hernia,however,predicted the need for operative intervention,while other findings(ascites,duodenal thickening)did not.Further research would be helpful to construct a prediction rule,which could help community EPs determine which patients may benefit from expedited transfer for operative management,and which patients could be safely managed conservatively as an initial treatment strategy. | Sarah E Frasure Amy Hildreth Sukhjit Takhar Michael B Stone | 2016 | World Journal of Emergency Medicine2016，7，1： | 2 |
| 4 | Spinal cord injury in children: long-term urodynamic and urological outcomes 显示文摘 | Generao S E Dall' era J P Stone A R | 2004 | J Urol2004，172，3： | 1 |
| 5 | Form and function of arabinogalactans and arabinogalactanproteins显示文摘 | Clarke A E Anderson R L Stone B A | 1979 | Phytochemistry1979，18，： | 1 |
| 6 | Stress related effects of hatchery rearing density on coho salmon显示文摘 | Fagcrlund U M Mcbride J R Stone E T | 1981 | Transactions of the American Fisheries Society1981，110，5： | 1 |
| 7 | A Fast DirectFourier-based Algorithm for Sub-pixel Registration of Images显示文摘 | STONE H ORCHARD M CHANG E C | 2001 | IEEE Transactions on Geoscience and Remote Sensing2001，39，10： | 1 |
| 8 | Nurse workingconditions,organizational climate,and intent to leave in ICUs : aninstrumental variable approach part I显示文摘 | Stone P Mooney-Kane C Larson E | 2007 | Health Serv Hes2007，42，3： | 1 |
| 9 | The Effects Of Physical Attractiveness On Job - related Outcomes: A Meta - analysis of Experimental Studies 显示文摘 | Megumi H Stone - Romero E F Coats G | 2003 | Personnel Psychology2003，56，2： | 1 |
| 10 | A fast direct Fou- rier-based algorithm for subpixel registration of images 显示文摘 | Stone H Orchard M Chang E | 2001 | IEEE Transactions on Geoscience and Remote Se- ning2001，39，10： | 1 |
| 11 | Stress-related effects of hatchery rearing density on coho salmon显示文摘 | Fagerlund U H M McBride J R Stone E T | 1981 | Trans Am Fish So1981，110，： | 1 |
| 12 | Wheat cultivars vary widely in their response of grain yield and quality of short period of post anthesis heat stress显示文摘 | STONE P J NICOLAS M E | 1994 | Australian Journal of Plant Physiology1994，21，： | 1 |
| 13 | Regulation of katF and katE in Escherlchia colt K-12 by weak acids 显示文摘 | SCHELLHORN H E STONES V L | 1992 | J Bacteriol1992，174，： | 1 |
| 14 | ARC1 is an E3 ubiquitin ligase and promotes the ubiquitination of proteins during the rejection of self-incompatible Brassica pollen 显示文摘 | Stone S L Anderson E M Mullen R T et cd | 2003 | Plant Cell2003，15，4： | 1 |
| 15 | Servant leadership: setting the stage for empirical research 显示文摘 | FARLING M L STONE A G WINSTON B E | 1999 | The Journal of Leadership Studies1999，，6： | 1 |
| 16 | A survey of the effect of high temperature during grain filling on yield and quality of 75 wheat cultivars显示文摘 | Stone P J Nicolas M E | 1995 | Aust J Agric Res1995，46，： | 1 |
| 17 | Behavior of post - tensioned girder anchorage zones显示文摘 | Stone W C Breen J E | 1984 | PCI Journal1984，29，1： | 1 |
| 18 | Primary structure and cellular localization of callinectin, an antimicrobial peptide from the blue crab 显示文摘 | Noga E J Stone K L Wood A | 2011 | Developmental & Comparative Immunology2011，35，4： | 1 |
| 19 | Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular disease:possible mechanisms显示文摘 | Kinsella J E Lokesh B Stone R A | 1990 | The American journal of clinical nutrition1990，52，1： | 1 |
| 20 | Genetic diversity of Salmonella pathogenicity islands SPI-5 and SPI-6 in Salmonella Newport显示文摘 | Cao G Allard M Strain E Stones R Zhao S Brown E Meng J | 2014 | Foodborne Pathog Dis2014，11，10： | 1 |
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