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| 1 | Improving the outcomes in gastric cancer surgery显示文摘Gastric cancer remains a significant health problem worldwide and surgery is currently the only potentially curative treatment option. Gastric cancer surgery is generally considered to be high risk surgery and fiveyear survival rates are poor,therefore a continuous strive to improve outcomes for these patients is warranted. Fortunately,in the last decades several potential advances have been introduced that intervene at various stages of the treatment process. This review provides an overview of methods implemented in pre-,intra- and postoperative stage of gastric cancer surgery to improve outcome. Better preoperative risk assessment using comorbidity index(e.g.,Charlson comorbidity index),assessment of nutritional status(e.g.,short nutritional assessment questionnaire,nutritional risk screening- 2002) and frailty assessment(Groningen frailty indicator,Edmonton frail scale,Hopkins frailty) was introduced. Also preoperative optimization of patients using prehabilitation has future potential.Implementation of fast-track or enhanced recovery after surgery programs is showing promising results,although future studies have to determine what the exact optimal strategy is.Introduction of laparoscopic surgery has shown improvement of results as well as optimization of lymph node dissection.Hyperthermic intraperitoneal chemotherapy has not shown to be beneficial in peritoneal metastatic disease thus far.Advances in postoperative care include optimal timing of oral diet,which has been shown to reduce hospital stay.In general,hospital volume,i.e.,centralization,and clinical audits might further improve the outcome in gastric cancer surgery.In conclusion,progress has been made in improving the surgical treatment of gastric cancer.However,gastric cancer treatment is high risk surgery and many areas for future research remain. | Juul JW Tegels Michiel FG De Maat Karel WE Hulsewé Anton GM Hoofwijk Jan HMB Stoot | 2014 | World Journal of Gastroenterology2014，20，38： | 16 |
| 2 | Improving the outcomes in oncological colorectal surgery显示文摘During the last several decades,colorectal cancer surgery has experienced some major perioperative improvements.Preoperative risk-assessment of nutrition,frailty,and sarcopenia followed by interventions for patient optimization or an adapted surgical strategy,contributed to improved postoperative outcomes.Enhanced recovery programs or fast-track surgery also resulted in reduced length of hospital stay and overall complications without affecting patient safety.After an initially indecisive start due to uncertainty about oncological safety,the most significant improvement in intraoperative care was the introduction of laparoscopy.Laparoscopic surgery for colon and rectal cancer is associated with better short-term outcomes,whereas long-term outcomes regarding survival and recurrence rates are comparable.Nevertheless,long-term results in rectal surgery remain to be seen.Early recognition of anastomotic leakage remains a challenge,though multiple improvements have allowed better management of this complication. | Jeroen LA van Vugt Kostan W Reisinger Joep PM Derikx Djamila Boerma Jan HMB Stoot | 2014 | World Journal of Gastroenterology2014，20，35： | 13 |
| 3 | Way forward: Geriatric frailty assessment as risk predictor in gastric cancer surgery显示文摘In gastric cancer patients chronological and biological age might vary greatly between patients. Age as well as American Society of Anaesthesiologists-physical status classifications are very non-specific and do not adequately predict adverse outcome. Improvements have been made such as the introduction of Charlson Comorbidity Index. Geriatric frailty is probably a better measure for patients resistance to stressors and physiological reserves. An increasing amount of evidence shows that geriatric frailty is a better predictor for adverse outcome after surgery, including gastric cancer surgery. Geriatric frailty can be assessed in a number of ways. Questionnaires such as the Groningen Frailty Indicator provide an ease and low cost method for gauging the presence of frailty in gastric cancer patients. This can then be used to provide a better preoperative risk assessment in these patients and improve decision making. | Juul JW Tegels Jan HMB Stoot | 2015 | World Journal of Gastrointestinal Surgery2015，7，10： | 3 |
| 4 | Introduction of laparoscopic gastrectomy for gastric cancer in a Western tertiary referral centre:A prospective cost analysis during the learning curve显示文摘AIM To evaluate the costs of the introduction of a laparoscopic surgery program for gastric cancer in a Western community training hospital and tertiary referral centre for gastric cancer surgery. METHODS All patients who underwent surgery for gastric cancer with curative intent in 2013 and 2014 were prospectively included. Primary outcomes were costs regarding surgery and hospital stay. RESULTS Laparoscopic gastrectomy was used in 52 patients [mean age 68 years(± 9, range 50 to 87) years] and open gastrectomy was used in 25 patients [mean age 70 years(± 10, range 46 to 85)]. Mean costs(in euro's) of surgical instrumentation were significantly higher for laparo-scopic surgery: 2270 ± 670 vs 1181 ± 680 in the open approach(P < 0.001). Costs of theatre use were higher in the laparoscopic group: mean 3818 ± 865 vs 2545± 1268 in the open surgery(P < 0.001). Total costs of hospitalization(i.e., costs of surgery and admission)were not different between laparoscopic and open surgery, 8187 ± 4864 and 6152 ± 2680 respectively(P= 0.729). Mean length of hospital stay was 9 ± 12 d in the laparoscopic group vs 14 ± 14 d in the open group(P= 0.044). CONCLUSION The introduction of laparoscopic gastrectomy for gastric cancer coincided with higher costs for theatre use and surgical instrumentation compared to the open technique. Total costs were not significantly different due to shorter length of stay and less intensive care unit(ICU) admissions and shorter ICU stay in the laparoscopic group. | Juul J Tegels Charlotte E Silvius Frederique E Spauwen Karel W Hulsewé Anton G Hoofwijk Jan H Stoot | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 2 |
| 5 | Application of the HACCP concept to improve the safety of street foods显示文摘 | Hartog B J Stoots J A M | 1992 | Food Lab News1992，8，2： | 1 |
| 6 | The effect of a multimodal fast-track programme on outcomes in laparoscopic liver surgery: a multicentre pilot study 显示文摘 | Stoot JH van Dam RM Busch OR | 2009 | HPB(Oxford)2009，11，2： | 1 |
| 7 | Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systemat- ic review including more than 1600 adenoma cases显示文摘 | Stoot JH Coelen RJ De Jonq MC | 2010 | HPB(Oxford)2010，12，8： | 1 |
| 8 | The mechanism of accumulation of tumour-localising radiopharmaceuticals显示文摘 | Pauwels EK McCready VR Stoot JH | 1998 | Eur J Nucl Med1998，25，3： | 1 |
| 9 | Life-saving therapy for haemorrhaging liver adenomas using selective arterial emboliza- tion显示文摘 | Terpstra OT Stoot JH Van EL | 2007 | Br J Surg2007，94，： | 1 |
| 10 | Whole blood cell counts and leucocyte differentials in patients with benign or malignant ovarian tumours显示文摘 | M. den Ouden J.M.H. Ubachs J.E.G.M. Stoot J.W.J. van Wersch | 1997 | European Journal of Obstetrics and Gynecology1997，，1： | 1 |
| 11 | 显示文摘 | Ribeiro M J Stoot JH | 1998 | Nucl Med Biol1998，25，4： | 1 |
| 12 | High frequency and high resolution capacitance measuring circuit for process tomography显示文摘 | YANG W Q STOOT A L BECK M S | 1994 | IEE Proceedings:Circuits Devices and Systems1994，141，3： | 1 |
| 13 | Prog-ress in high-temperature electrolysis for hydrogen production using planar SOFC technology显示文摘 | Stephen Herring J James E O'Brien Carl M Stoots | | 0，，： | 1 |
| 14 | Whole blood cell counts and leueocyte differentials in patients with benign or malignant ovarian tumours显示文摘 | M den Ouden J Ubachs J Stoot | 2009 | Eur J Obstet Gynecol Reprod Biol2009，72，1： | 1 |
| 15 | Necrosis of a large hepatic tumor after hemorrhage and subsequent selective arterial embolization显示文摘This case report describes a young female patient presenting with acute intra-abdominal hemorrhage originating from a large tumor in the liver, most likely a hepatocellular adenoma. The bleeding was stopped by selective embolization of right hepatic artery branches. Subsequently, partial hepatectomy was performed after 6 mo. Macro- and microscopic examination showed complete necrosis and absence of tumorous tissue. The patient was discharged without complications, and subsequent follow-up until 22 mo after resection did not reveal any new lesions in the liver. This case emphasizes the signifi cance of selective arterial embolization in the management of bleeding liver tumors and questions the need for (partial) hepatectomy after this procedure in selective cases. | Volkert AL Huurman Jan HMB Stoot Edwin van der Linden Alexander F M Schaapherder Onno T Terpstra Alexander FM Schaapherder | 2006 | World Journal of Gastroenterology2006，12，37： | 1 |
| 16 | Results of recent high temperature coelectrolysis studies at the Idaho National Laboratory显示文摘 | Carl Stoots James O'Brien Joseph Hartvigsen | | 0，，： | 1 |
| 17 | Progress in high-temperature electrolysis for hydrogen production using planar SOFC technology显示文摘 | Herring J S O'Brien J E Stoots C M | 2007 | Int J Hydrogen Energy2007，32，： | 1 |
| 18 | FDG accumulation and tumor biology显示文摘 | Pauwels E K Ribeiro M J Stoot J H | 1998 | Nucl Med Bio11998，25，4： | 1 |
| 19 | Parametric study of large-scale production of syngas via high-temperature co-electrolysis显示文摘 | O'Brien J E Mckellar M G Stoots C M | | 0，，： | 1 |
| 20 | Results of recent high temperature coelectrolysis studies at the Idaho National Labora-tory显示文摘 | Stoots C M O'Brien J E Hartvigsen J | | 0，，： | 1 |
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