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| 1 | The unique structural and functional features of CXCL12显示文摘The CXC chemokine CXCL12 is an important factor in physiological and pathological processes, includingembryogenesis, hematopoiesis, angiogenesis and inflammation, because it activates and/or induces migration ofhematopoietic progenitor and stem cells, endothelial cells and most leukocytes. Therefore, CXCL12 activity istightly regulated at multiple levels. CXCL12 has the unique property of existing in six splice variants in humans,each having a specific tissue distribution and in vivo activity. Controlled splice variant transcription and mRNAstability determine the CXCL12 expression profile. CXCL12 fulfills its functions in homeostatic and pathologicalconditions by interacting with its receptors CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3(ACKR3) and by binding to glycosaminoglycans (GAGs) in tissues and on the endothelium to allow a properpresentation to passing leukocytes. Homodimerizaton and heterodimerization of CXCL12 and its receptors can altertheir signaling activity, as exemplified by the synergy between CXCL12 and other chemokines in leukocyte migrationassays. Receptor binding may also initiate CXCL12 internalization and its subsequent removal from theenvironment. Furthermore, CXCL12 activity is regulated by posttranslational modifications. Proteolytic removal ofNH2- or COOH-terminal amino acids, citrullination of arginine residues by peptidyl arginine deiminases or nitrationof tyrosine residues reduce CXCL12 activity. This review summarizes the interactions of CXCL12 with the cellularenvironment and discusses the different levels of CXCL12 activity regulation. | Rik Janssens Sofie Struyf Paul Proost | 2018 | Cellular & Molecular Immunology2018，15，4： | 28 |
| 2 | Chemoattractants and cytokines in primary ciliary dyskinesia and cystic fibrosis: key players in chronic respiratory diseases显示文摘Patients with primary ciliary dyskinesia(PCD)and cystic fibrosis(CF),two inherited disorders,suffer from recurrent airway infections characterized by persistent bacterial colonization and uncontrollable inflammation.Although present in high counts,neutrophils fail to clear infection in the airways.High levels of C-X-C motif chemokine ligand 8/interleukin-8(CXCL8/IL-8),the most potent chemokine to attract neutrophils to sites of infection,are detected in the sputum of both patient groups and might cause the high neutrophil influx in the airways.Furthermore,in CF,airway neutrophils are highly activated because of the genetic defect and the high levels of proinflammatory chemoattractants and cytokines(e.g.,CXCL8/IL-8,tumor necrosis factor-αand IL-17).The overactive state of neutrophils leads to lung damage and fuels the vicious circle of infection,excessive inflammation and tissue damage.The inflammatory process in CF airways is well characterized,whereas the lung pathology in PCD is far less studied.The knowledge of CF lung pathology could be useful to guide molecular investigations of the inflammatory processes in PCD lungs.Current available therapies can not completely remedy the chronic airway infections in these diseases.This review gives an overview of the role that chemoattractants and cytokines play in these neutrophil-dominated lung pathologies.Finally,the most frequently applied treatments in CF and PCD and new experimental therapies to reduce neutrophil-dominated airway inflammation are described. | Maaike Cockx Mieke Gouwy Jo Van Damme Sofie Struyf | 2018 | Cellular & Molecular Immunology2018，15，4： | 3 |
| 3 | Dynamics of biogenic Siin freshwater tidal marshes:Si regeneration and retention inmarsh sediments (Scheldt estuary) 显示文摘 | Struyf E Temmerman S Meire P | 2007 | Biogeochemistry2007，82，： | 1 |
| 4 | Mutations in the N-terminal domains of nectin-1 and nectin-2 reveal differences in requirements for entry of various alphaherpes viruses and for nectin-nectin interactions显示文摘 | Struyf F Martinez WM Spear PG | 2002 | J Virol2002，76，12： | 1 |
| 5 | Functional characterization of human receptors for short chain fatty acids and their role in polymorphonu- clear cell activation显示文摘 | LE POUL E LOISON C STRUYF S | 2003 | J Biol Chem2003，278，25： | 1 |
| 6 | An enormousamorphous silica stock in boreal wetlands显示文摘 | Struyf E M?rth CM Humborg C Conley DJ | 2010 | Journal ofGeophysical Research2010，115，04： | 1 |
| 7 | The role of CXC ehemokines and their receptors in cancer显示文摘 | Vandercappellen J Van Damme J Struyf S | 2008 | Cancer Lett2008，267，2： | 1 |
| 8 | Synergy between proinflammatory ligands of G protein - coupled receptors in neutrophil activation and migration显示文摘 | Gouwy M Struyf S Catusse J | 2004 | J Leukoc Biol2004，76，1： | 1 |
| 9 | Constructivist learning environments and the (im)possibility to change students' perceptions of assessment demands and approaches to learning显示文摘 | David Gijbels Mien Segers & Elke Struyf | 2008 | Journal Instructional Science2008，，36： | 1 |
| 10 | MCP-3 (CCL7) delivered by parvovirus MVMp reduces lumorigenicity of mouse melanoma cells through activation of T lymphocyles and NK cells显示文摘 | Wetzel K Struyf S Van Damme J | 2007 | Int J Cancer2007，120，6： | 1 |
| 11 | Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy显示文摘 | Abu El-Asrar AM Struyf S Kangave D | 2006 | Eur Cytokine Net2006，17，3： | 1 |
| 12 | Unique regulation of CCL18 production by maturing dendritic cells显示文摘 | VULCANO M STRUYF S SCAPINI P | 2003 | J Immunol2003，170，7： | 1 |
| 13 | Processing by CD26/dipep- tidyl-peptidase IV reduces the chemotactic and anti-HIV-I ac- tivity of stromal-cell-derived factor-lalpha 显示文摘 | Proost P Struyf S Schols D | 1998 | FEBS Lett1998，432，12： | 1 |
| 14 | Synergy in cytokine and che- mokine networks amplifies the inflammatory response 显示文摘 | Gouwy M Struyf S Proost P | 2005 | Cyto- kine Growth Factor Rev2005，16，6： | 1 |
| 15 | The CC chemokine CCL20 and its receptor CCR6 显示文摘 | Schutyser E Struyf S Van Damme J | 2003 | Cytokine Growth Factor Rev2003，14，5： | 1 |
| 16 | A Robust Measure of Skew-ness显示文摘 | Brys G Hubert M Struyf A | 2004 | Journal of Computational and Graphical Statistics2004，13，4： | 1 |
| 17 | Synergy in cytokine and chemokine networks amplifies the inflammatory response显示文摘 | GOUWY M STRUYF S PROOST P | 2005 | Cytokine & Growth Factor Reviews2005，16，： | 1 |
| 18 | The role of CXC chemokines and their receptors in cancer 显示文摘 | Vandercappellen J van Damme J Struyf S | 2008 | Cancer Lett2008，267，2： | 1 |
| 19 | Clinical assessment of scapular positioning in patients with shoulder pain: state of the art显示文摘 | Nijs J Roussel N Struyf F | 2007 | J Manipulative Physiol Ther2007，30，1： | 1 |
| 20 | Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis显示文摘 | E1-Asrar AM Struyf S Kangave D | 2011 | Clin Immunol2011，139，： | 1 |
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