|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 3 | Treatment results for naso- pharyngeal carcinoma in the modern era: the Hong Kong experi- ence显示文摘 | LEE A W SZE W M AU J S | 2005 | Int J Radiat Oncol Biol Phys2005，61，4： | 1 |
| 4 | Volvariella volvacea lectinactivates mouse T lymphocytes l)y a calcium dependent pathway显示文摘 | Sze S C W Ho J C K Liu W K | 2004 | J Cell Biochem2004，92，6： | 1 |
| 5 | Modeling complex heterogeneous objects with non-manifold heterogeneous cells 显示文摘 | Kou X Y Tan S T Sze W S | 2006 | Computer-Aided Design2006，38，： | 1 |
| 6 | A new key frame representation for video segment retrieval显示文摘 | Sze K W Lam K M Qiu G P | 2005 | IEEE Transactions on Circuits and Systems for Video Technology2005，15，9： | 1 |
| 7 | Parting line formation by slicing a 3D CAD model显示文摘 | WONG T TAN S T SZE W S | 1998 | Engineering with Computers1998，，14： | 1 |
| 8 | Palliation of metastatic bone pain; single fraction versus multifraction radiotherapy--a systematic review of the randomized trials 显示文摘 | Sze W M Shelley M Held I | 2004 | Cochrane Database Syat Rev2004，，00： | 1 |
| 9 | miR-200a regulates epithelial-mesenchymal to stem-like transition via ZEB2 and beta- catenin signaling 显示文摘 | XIA Hong-ping Cheung W K Sze J | 2010 | J Biol Chem2010，285，36： | 1 |
| 10 | Treatment results for nasopharyngeal carcinoma in the modern era:the Hong Kong experience显示文摘 | Lee A W Sze W M Au J S | 2005 | Int J Radiat Oncol Biol Phys2005，61，4： | 1 |
| 11 | Multidetector CT angiography of pediat-ric vascular malformations and hemangiomas : utility of 3D reformatting in differential diagnosis显示文摘 | BITYLES M A SIDHU M K SZE R W | 2005 | Pediatr Radiol2005，35，11： | 1 |
| 12 | Treatment of hepatocellular carcinoma with subselective transcatheter arterial oily chemoinfusion 显示文摘 | Kim P Prapong W Sze DY | 2002 | Tech Vasc Interv Radiol2002，5，3： | 1 |
| 13 | Action of alpha momorcharin,aribosome inactivating protein,on cμLtured tumor celllines显示文摘 | Ng T B Liu W K Sze S F | 1994 | Gen Pharmacol1994，251，： | 1 |
| 14 | Primary tumor volume of nasopharyngeal carcinoma:prognostic significance for local control 显示文摘 | Sze W M Lee A W Yau T K | 2004 | Int J Radiat Oncol Biol Phys2004，59，1： | 1 |
| 15 | The uptake of Cd,Cr,and Zn by the macroalga Enteromorpha crinita and subsequent transfer to the marine herbivorous rabbitfish,Siganus canaliculatus显示文摘 | Sze M C Wen-Xiong W I-Hsun Ni | 2003 | Arch Environ Contam Toxicol2003，44，： | 1 |
| 16 | Chrysotoxine,a novel bibenzyl compound,inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via mitochondria protection and NF-κB modulation显示文摘 | Song J X Shaw P C Sze C W | 2010 | Neurochem Int2010，57，6： | 1 |
| 17 | Parting line formation by slicing a 3D CAD model显示文摘 | WONG T TAN S T SZE W S | 1998 | Engineering with Computers1998，14，4： | 1 |
| 18 | Quality as sessment of Cortex Phellodendri by high-performance liquid chromatography coupled with eleetrospray ionization mass spectrometry显示文摘 | Hu YongMei Su GuangHai Sze S C W | 2010 | Biomed Chromatogr2010，24，4： | 1 |
| 19 | The chlorine budget of the present atmosphere:a modeling study显示文摘 | Winsenstein D K KO M K W Sze N | 1992 | Journal of Geophysical Research1992，97，： | 1 |
| 20 | Quality assessment of Cortex Phellodendri by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry 显示文摘 | Hu Y M Su G H Sze S C W | 2010 | Biomed Chromatogr2010，24，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员