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| 1 | 初级保健中原发性醛固酮增多症的患病率和临床表现显示文摘原发性醛固酮增多症(primaryaldosteronism,PA)是一种异质性疾病,以高血压和相对自主于肾素血管紧张素系统产生过量醛固酮为特征。与心血管病风险相似的原发性高血压患者相比,PA患者发生心脑血管并发症的风险以及代谢综合征患病率增加,提示正确诊断PA的重要性。 | Monticone S Burrello J Tizzani D Bertello C Viola A Buffolo F Gabetti L Mengozzi G Williams TA Rabbia F Veglio F Mulatero P 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 58 |
| 2 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 3 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 4 | Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats显示文摘AIM:To determine the temporal expression and pattern of Rel/nuclear factor(NF)-κB proteins in renal tissue in polycystic kidney disease(PKD). METHODS: The renal expression of Rel/NF-κB proteins was determined by immunohistochemistry, immunofluorescence and immunoblot analysis in Lewis polycystic kidney rats(LPK, a genetic ortholog of human nephronopthsis-9) from postnatal weeks 3 to 20. At each timepoint, renal disease progression and the mR NA expression of NF-κB-dependent genes(TNFa and CCL2) were determined. NF-κB was also histologicaly assessed in human PKD tissue.RESULTS: Progressive kidney enlargement in LPK rats was accompanied by increased renal cell proliferation and interstitial monocyte accumulation(peaking at weeks 3 and 10 respectively), and progressive interstitial fibrosis(with a smooth muscle actin and Sirius Red deposition significantly increased compared to Lewis kidneys from weeks 3 to 6 onwards). Rel/NF-κB proteins(phosphorylated-p105, p65, p50, c-Rel and RelB) were expressed in cystic epithelial cells(CECs) of LPK kidneys as early as postnatal week 3 and sustained until latestage disease at week 20. From weeks 10 to 20, nuclear p65, p50, Rel B and cytoplasmic IκBa protein levels, and TNFa and CCL2 expression, were upregulated in LPK compared to Lewis kidneys. NF-κB proteins were consistently expressed in CECs of human PKD. The DNA damage marker γ-H2AX was also identified in the CECs of LPK and human polycystic kidneys. CONCLUSION: Several NF-κB proteins are consistently expressed in CECs in human and experimental PKD. These data suggest that the upregulation of both the canonical and non-canonical pathways of NF-κB signaling may be a constitutive and early pathological feature of cystic renal diseases. | Michelle HT Ta Kristina G Schwensen David Liuwantara David L Huso Terry Watnick Gopala K Rangan | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 5 | Scanometric DNA Array Detection with Nanoparticle Probes显示文摘 | CA M RL L | 2000 | Science2000，289，5485： | 1 |
| 6 | Ligand binding to integrins显示文摘 | Plow EF Haas TA Zhang L | 2000 | J Biol Chem2000，275，21： | 1 |
| 7 | Natural killer cell receptors:new biology and insights into the graftversus-leukemia effect显示文摘 | Farag SS Fehniger TA Ruggeri L | 2002 | Blood2002，100，6： | 1 |
| 8 | The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription显示文摘 | Zhao L Guo M Matsuoka TA | 2005 | J Biol Chem2005，280，11： | 1 |
| 9 | Ownership structure and risk in publicly held and privately owned banks 显示文摘 | Barry TA Lepetit L Tarazi A | 2011 | Journal of Banking and Finance2011，35，5： | 1 |
| 10 | Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring显示文摘 | Kryger ZB Sisco M Roy NK Lu L Rosenberg D Mustoe TA | | 0，，01： | 1 |
| 11 | Efficient patient identification strategies for women with osteoporosis显示文摘 | Abbott TA 3rd Mucha L Manfredonia D | | 0，，03： | 1 |
| 12 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 13 | Rapid palatal expansion followed by fixed appliances:a long-term evaluation of changes in arch dimension显示文摘 | McNamara JA Baccetti T Fianchi L Herberger TA | | 0，，04： | 1 |
| 14 | Robot-assisted gait training for patients with hemiparesis due to stroke 显示文摘 | Fisher S Lucas L Thrasher TA | 2011 | Top Stroke Reeabil2011，18，3： | 1 |
| 15 | Interleukin-17 family and IL-17 receptors 显示文摘 | Moseley TA Haudenschild DR Rose L | 2003 | Cytokine Growth Factor Rev2003，14，2： | 1 |
| 16 | Interleukin-17 family and IL-17 receptors显示文摘 | Moseley TA Haudenschild DR Rose L | 2003 | Cytokine Growth Factor Rev2003，14，2： | 1 |
| 17 | Airway inflammation in nonobstructive and obstructive chronic bronchitis with chronic Haemophitus influenzae airway infection: comparison with noninfected patients with chronic obstructive pulmonary disease显示文摘 | Bresser P Out TA van Alphen L | 2000 | Am J Respir Crit Care Med2000，162，31： | 1 |
| 18 | Ankle--arm index as a predictor of cardiovascular disease andmortality in the Cardiovascular Health Study 显示文摘 | Newman AB Shemanski L Manolio TA | 1999 | Arterioscler Thromb Vasc Bio1999，19，： | 1 |
| 19 | Impact of influenza vaccination on seasonal mortality in the US elderly population显示文摘 | Simonsen L Reichert TA Viboud C | 2005 | Arch Intern Med2005，165，3： | 1 |
| 20 | Breast density in relation to risk of ductual carcinoma in situ of the breast in women undergoing screening mammography 显示文摘 | MacKenzie TA Tit us-Ernstoff L Vaeek PM | 2007 | Cancer Causes Contr2007，18，9： | 1 |
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