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| 1 | Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis显示文摘BACKGROUND The coexistence of sarcopenia and obesity is referred to as sarcopenic obesity(SO)and it has been hypothesized that the two components of SO may synergistically increase their negative effects. However, many uncertainties still surround this condition especially with regard to its potential negative effects on health outcomes.AIM To conduct a systematic review to determine the prevalence of sarcopenia among adults with overweight and obesity and to investigate whether SO was associated with a higher risk of type 2 diabetes(T2 D).METHODS This study was conducted in adherence with the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Literature searches, study selection, methodology development and quality appraisal were performed independently by two authors and the data were collated by means of metaanalysis and narrative synthesis.RESULTS Of the 606 articles retrieved, 11 studies that comprised a total of 60118 adults with overweight and obesity of both genders met the inclusion criteria and were reviewed, revealing two main findings. First, the overall prevalence of sarcopenia is 43% in females and 42% in males who are with overweight and obesity.Secondly, the presence of SO increases the risk of T2D by 38% with respect to those without SO(OR = 1.38, 95%CI: 1.27-1.50).CONCLUSION A high prevalence of sarcopenia has been found among adults with overweight and obesity regardless of their gender and this condition seems to be associatedwith a higher risk of T2D. Clinician should be aware of this scenario in their clinical practice for the better management of both obesity and T2D. | Dima Khadra Leila Itani Hana Tannir Dima Kreidieh Dana El Masri Marwan El Ghoch | 2019 | World Journal of Diabetes2019，10，5： | 6 |
| 2 | Collision tumor of the kidney composed of clear cell carcinoma and collecting duct carcinoma: report of a case with unusual morphology and clinical follow-up显示文摘We report the case of a 67-year-old female who presented with a large renal mass. Gross examination of the nephrectomy specimen demonstrated a 6-cm renal mass that invaded into the renal sinus and perinephric fat. Histologic examination revealed two distinct tumor types. The first type was a conventional(clear cell) renal cell carcinoma that was of low nuclear grade and comprised the minority of the overall tumor. The second type was a high-grade collecting duct carcinoma with glandular/tubular differentiation and composed the majority of the tumor. Immunohistochemical studies demonstrated distinctive patterns of the two tumor types, thus confirming two distinct lineages. Five months postoperatively, the patient developed metastasis to the lungs and right hilar lymph node region. A fine needle aspiration of a lung nodule demonstrated a metastatic, poorly differentiated carcinoma, similar to the collecting duct carcinoma component in the kidney. Collision tumors of the kidney are rare with fewer than 10 cases reported in the literature. Our report further expands the spectrum of this rare phenomenon. | Rhonda Burch-Smith Nizar M Tannir Erika Resetkova Pheroze Tamboli Priya Rao | 2014 | Chinese Journal of Cancer2014，33，7： | 3 |
| 3 | Gene and protein expression markers of response tocombined antiangiogenic and epidermal growth factortargeted therapy in renal cell carcinoma显示文摘 | TsavachidouFenner D Tannir N Tamboli P | 2010 | Ann On-coU2010，21，8： | 1 |
| 4 | Heart failure associated with sunitinib rnalate a multitargeted receptor tyrosine kinase inhibitor 显示文摘 | Khakoo Ay Kassiatis CM Tannir N | 2008 | Cancer2008，112，11： | 1 |
| 5 | Correlation of survival with tumor histology, age, and prognostic risk group for previously untreated patients with advanced renal cell carcinoma ( adv RCC) receiving temsirolimus (TEMSR) or interferon-alpha (IFN)显示文摘 | DUTCHER JP SZCZYLIK C TANNIR N | 2007 | J Clin Oncol2007，25，： | 1 |
| 6 | A Phase II Trial of Gemcitabine Plus Capecitabine for Metastatic Renal Cell Cancer Previously Treated With Immunotherapy and Targeted Agents显示文摘 | Nizar M. Tannir Peter F. Thall Chaan S. Ng Xuemei Wang Leiko Wooten Arlene Siefker-Radtke Paul Mathew Lance Pagliaro Christopher Wood Eric Jonasch | 2007 | The Journal of Urology2007，，： | 1 |
| 7 | Primary tumor response to targeted agents in patients with metastatic renal cell carcinoma 显示文摘 | Abel EJ Culp SH Tannir NM | 2011 | European urology2011，59，1： | 1 |
| 8 | Role of partial nephrectomyas cytoreduction in the management of metastatic renal cell carcinoma显示文摘 | Karam JA Babaian KN Tannir NM | 2015 | Minerva Urol Nefrol2015，67，2： | 1 |
| 9 | Role of partial nephrectomy as cytoreduction in the management of metastatic renal cell carcinoma 显示文摘 | Karam JA BaLalan KN Tannir NM | 2015 | Minerva Urol Nefrol2015，67，： | 1 |
| 10 | Age-related evolution of amyloid burden,iron load,and MR relaxation times in a transgenic mouse model of Alzheimer's disease显示文摘 | El Tannir El Tayara N Delatour B Le Cudennec C | 2006 | Neurobiol Dis2006，22，： | 1 |
| 11 | Repetitive paravertebral nerve block using a catheter technique for pain relief in postherpetic neuralgia显示文摘 | Najal ZM Maaliki H Tannir MA | 2006 | BJ A2006，96，3： | 1 |
| 12 | Occipital nerve blockade for cervicogenie headache: a double blind randomized controlled clinical trial显示文摘 | Naja ZM El-Rajab M AI Tannir MA el al | 2006 | Pain Pract2006，6，2： | 1 |
| 13 | Patterns of disease pro- gression in metastatic renal cell carcinoma patients treated with antivascular agents and interferon 显示文摘 | Plimack E R Tannir N Lin E | 2009 | Cancer2009，115，9： | 1 |
| 14 | Landscape of DNA virus associations across human malignant cancers:analysis of 3775cases using RNA-Seq显示文摘 | Khoury J D Tannir N M Williams M D | 2013 | J Virol2013，87，16： | 1 |
| 15 | Targeted therapy for locally advanced renal cell carcinoma显示文摘 | Jonasch E Tannir NM | 2010 | Target Oncol2010，5，： | 1 |
| 16 | Surgical morbidity associated with administration of targeted molecular therapies before cytoreductive nephrectomy or resection of locally recurrent renal cell carcinoma显示文摘 | Margulis V Matin SF Tannir N | 2008 | Journal of Urology2008，，01： | 1 |
| 17 | Early primary tumor size reduction is an independent predictor of improved o- verall survival in metastatic renal cell carcinoma patients treated with sunitinib显示文摘 | ABEL EJ CULP SH TANNIR NM | 2011 | Eur Urol2011，60，6： | 1 |
| 18 | Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice 显示文摘 | Dhenain M Tannir E Tayara N | 2009 | Neurobiol Aging2009，30，： | 1 |
| 19 | Randomized trial of ad- juvant thalidomide versus observation in patients with completely resected high-risk renal cell carcinoma 显示文摘 | Margulis V Matin SF Tannir N | 2009 | Urology2009，73，2： | 1 |
| 20 | A phase II trial of gefitinib in patients with non-metastatic hormone-refractory prostate cancer显示文摘 | Small E J Fontana J Tannir N | 2007 | BJU Int2007，100，4： | 1 |
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