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| 1 | Rituximab or plasmapheresis for prevention of recurrent focal segmental glomerulosclerosis after kidney transplantation:A systematic review and meta-analysis显示文摘BACKGROUND Focal segmental glomerulosclerosis(FSGS)is one of the most common glomerular diseases leading to renal failure.FSGS has a high risk of recurrence after kidney transplantation.Prevention of recurrent FSGS using rituximab and/or plasmapheresis has been evaluated in multiple small studies with conflicting results.AIM To assess the risk of recurrence of FSGS after transplantation using prophylactic rituximab with or without plasmapheresis,and plasmapheresis alone compared to the standard treatment group without preventive therapy.METHODS This meta-analysis and systematic review were performed by first conducting a literature search of the MEDLINE,EMBASE,and Cochrane databases,from inception through March 2021;search terms included‘FSGS,’’steroid-resistant nephrotic syndrome’,‘rituximab,’and‘plasmapheresis,’.We identified studies that assessed the risk of post-transplant FSGS after use of rituximab with or without plasmapheresis,or plasmapheresis alone.Inclusion criteria were:Original,published,randomized controlled trials or cohort studies(either prospective or retrospective),case-control,or cross-sectional studies;inclusion of odds ratio,relative risk,and standardized incidence ratio with 95%confidence intervals(CI),or sufficient raw data to calculate these ratios;and subjects without interventions(controls)being used as comparators in cohort and cross-sectional studies.Effect estimates from individual studies were extracted and combined using a random effects model.RESULTS Eleven studies,with a total of 399 kidney transplant recipients with FSGS,evaluated the use of rituximab with or without plasmapheresis;thirteen studies,with a total of 571 kidney transplant recipients with FSGS,evaluated plasmapheresis alone.Post-transplant FSGS recurred relatively early.There was no significant difference in recurrence between the group that received rituximab(with or without plasmapheresis)and the standard treatment group,with a pooled risk ratio of 0.82(95%CI:0.47-1.45,I2=65%).Similarly,plasmapheresis alone was not associated with any significant difference in FSGS recurrence when compared with no plasmapheresis;the pooled risk ratio was 0.85(95%CI:0.60-1.21,I2=23%).Subgroup analyses in the pediatric and adult groups did not yield a significant difference in recurrence risk.We also reviewed and analyzed posttransplant outcomes including timing of recurrence and graft survival.CONCLUSION Overall,the use of rituximab with or without plasmapheresis,or plasmapheresis alone,is not associated with a lower risk of FSGS recurrence after kidney transplantation.Future studies are required to assess the effectiveness of rituximab with or without plasmapheresis among specific patient subgroups with high-risk for FSGS recurrence. | Boonphiphop Boonpheng Panupong Hansrivijit Charat Thongprayoon Shennen A Mao Pradeep K Vaitla Tarun Bathini Avishek Choudhury Wisit Kaewput Michael A Mao Wisit Cheungpasitporn | 2021 | World Journal of Transplantation2021，11，7： | 2 |
| 2 | Standing waves in a non-linear 1D lattice: Floquet multipliers Krein signatures, and stability 显示文摘 | Subhendu Panda Anindita Lahiri Tarun K Roy | 2005 | Physica D2005，210，： | 1 |
| 3 | On the incentives for cooperative research显示文摘 | Tarun K | | 0，，01： | 1 |
| 4 | On the welfare analysis of a cross-border merger 显示文摘 | Tarun K Manas C | 1999 | The Journal of International Trade & Economic Development1999，8，2： | 1 |
| 5 | The dynamics of learning alliances: competition, cooperation, and relative scope 显示文摘 | Tarun K | 1998 | Strategic Management Journal1998，19，3： | 1 |
| 6 | Removal of VOCs from air by membrane-based absorption and stripping显示文摘 | TARUN K P SUDIPTO M KAMALEMSH K S | 1996 | Journal of Membrane Science1996，120，2： | 1 |
| 7 | Sr and 87Sr/86Sr in the Yamuna River System in the Himalaya:Sources,fluxes, and control on Sr isotopes composition显示文摘 | Tarun K D Krishnaswami S Anil K | 2003 | Geochimica et Cosmochimica Acta2003，67，16： | 1 |
| 8 | Is Group Affiliation Profitable in Emerging Markets?An Analysis of Diversified Indian Business Groups显示文摘 | KHANNA TARUN PALEPU K | 2000 | Journal of Finance2000，55，： | 1 |
| 9 | On the welfare analysis of a crossborder merger显示文摘 | Tarun K Manas C | 1999 | The Journal of International Trade & Economic Development1999，8，2： | 1 |
| 10 | Effect of TiO2 and nanoclay on the properties of wood polymer nanocomposite 显示文摘 | DEKA B K TARUN K M | 2011 | Composites Part A2011，42，12： | 1 |
| 11 | Calcium alginate/PVA blended nano fibre matrix for wound dressing显示文摘 | Tarun K Gobi N | 2012 | Indian J Fibre Textile Res2012，37，： | 1 |
| 12 | Effect ofnano-ZnO on thermal, mechanical, UV stability, and other physical properties of wood polymer composites 显示文摘 | Rashmi R D Tarun K M | 2012 | Industial & Engineering Chemistry Research2012，51，10： | 1 |
| 13 | On the welfare analysis of a cross-border merger显示文摘 | Tarun K Manas C | 1999 | The Journal of International Trade & Economic Development1999，8，2： | 1 |
| 14 | Why Focused Strategies May Be Wrong for Emerging Markets显示文摘 | Tarun Khanna K P | 1997 | Harvard Business Review1997，75，4： | 1 |
| 15 | Antifungal activity of 4-methyl-6-alkyl- 2H-pyran-2-ones 显示文摘 | Tarun K C Prem D J | 2006 | J Agric Food Chem2006，54，： | 1 |
| 16 | Mobile stroke care expedites intravenous thrombolysis and endovascular thrombectomy显示文摘Background The number of mobile stroke programmes has increased with evidence,showing they expedite intravenous thrombolysis.Outstanding questions include whether time savings extend to patients eligible for endovascular therapy and impact clinical outcomes.Objective Our mobile stroke unit(MSU),based at an academic medical centre in upstate New York,launched in October 2018.We reviewed prospective observational data sets over 26 months to identify MSU and non-MSU emergency medical service(EMS)patients who underwent intravenous thrombolysis or endovascular thrombectomy for comparison of angiographic and clinical outcomes.Results Over 568 days in service,the MSU was dispatched 1489 times(2.6/day)and transported 300 patients(20%of dispatches).Intravenous tissue plasminogen activator(tPA)was administered to 57 MSU patients and the average time from 911 call-to tPA was 42.5 min(±9.2),while EMS transported 73 patients who received tPA at 99.4 min(±35.7)(p<0.001).Seven MSU patients(12%)received tPA from 3.5 hours to 4.5 hours since last known well and would likely have been outside the window with EMS care.Endovascular thrombectomy was performed on 21 MSU patients with an average 911 call-to groin puncture time of 99.9 min(±18.1),while EMS transported 54 patients who underwent endovascular thrombectomy(ET)at 133.0 min(±37.0)(p=0.0002).There was no difference between MSU and traditional EMS in modified Rankin score at 90-day clinic follow-up for patients undergoing intravenous thrombolysis or endovascular thrombectomy,whether assessed as a dichotomous or ordinal variable.Conclusions Mobile stroke care expedited both intravenous thrombolysis and endovascular thrombectomy.There is an ongoing need to show improved functional outcomes with MSU care. | Matthew T Bender Thomas K Mattingly Redi Rahmani Diana Proper Walter A Burnett Jason L Burgett Joshua LEsperance Jeremy T Cushman Webster H Pilcher Curtis G Benesch Adam G Kelly Tarun Bhalla | 2022 | Stroke & Vascular Neurology2022，7，3： | 1 |
| 17 | The dynamics of learning alliances: competition, cooperation, and relative scope 显示文摘 | Tarun K | 1998 | Strategic Management Journal1998，19，3： | 1 |
| 18 | A new histological grading system to assess response of breast cancers to primary chemotherapy: prognostic significance and survival显示文摘 | Keith N Ogston Iain D Miller Simon Payne Andrew W Hutcheon Tarun K Sarkar Ian Smith A Schofield Steven D Heys | 2003 | The Breast2003，，5： | 1 |
| 19 | Predicting Bond Ratings Using Neural Networks:A Comparison with Logistic Regression 显示文摘 | Maher J J Tarun K S | 1997 | Intelligent Systems in Accounting Finance and Management1997，，6： | 1 |
| 20 | Effects of heavy metals on population growth and metallothionein gene expression in the mosquito Culex quinquefasciatus,from Calcutta,India显示文摘 | Sagartirtha S Asish K Tarun K | 2004 | Environmental Pollution2004，127，2： | 1 |
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