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| 1 | Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan显示文摘AIM:To evaluate the prevalence of Helicobacter pylori(H.pylori ) babA2 ,babB and a recombinant gene between babA2 and babB(babA2/B ),and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates.METHODS:A total of 95 continuous H.pylori-positive Costa Rican(41 males and 54 females;mean age,50.65 years;SD,± 13.04 years) and 95 continuous H.pylori-positive Japanese(50 males and 45 females;mean age,63.43;SD,± 13.21 years) patients underwent upper endoscopy from October 2005 to July 2006.They were enrolled for the polymerase chain reaction(PCR)-based genotyping of the H.pylori babA2 ,babB and babA2/B genes.Statistical analysis was performed using the χ2 test and the Fisher's exact probability test and multivariate analysis was performed by logistic regression adjusting for gender and age.P < 0.05 was regarded as statistically significant.RESULTS:The PCR-based genotyping of 95 Costa Rican and 95 Japanese isolates showed a higher prevalence of babA2 in Japan(96.8%) than in Costa Rica(73.7%),while that of babA2/B was higher in Costa Rica(11.6%) than in Japan(1.1%).In Costa Rican isolates only,babA2 was significantly associated with atrophic gastritis(P = 0.01).CONCLUSION:These results suggest that the status of babA2 and babA2/B shows geographic differences,and that babA2 has clinical relevance in Costa Rica. | Sergio A Con Hiroaki Takeuchi Mitsuaki Nishioka Norihito Morimoto Tetsuro Sugiura Nobufumi Yasuda Reinaldo Con-Wong | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 2 | Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation显示文摘AIM:To investigate genetic diversity of Helicobacter pylori (H.pylori) cell division-related gene A (cdrA) and its effect on the host response.METHODS:Inactivation of H.pylori cdrA,which is involved in cell division and morphological elongation,has a role in chronic persistent infections.Genetic property of H.pylori cdrA was evaluated using polymerase chain reaction and sequencing in 128 (77 American and 51 Japanese) clinical isolates obtained from 48 and 51 patients,respectively.Enzyme-linked immunosorbent assay was performed to measure interleukin-8 (IL-8) secretion with gastric biopsy specimens obtained from American patients colonized with cdrA-positive or-negative strains and AGS cells cocultured with wild-type HPK5 (cdrA-positive) or its derivative HPKT510 (cdrA-disruptant).Furthermore,the cytotoxin-associated gene A (cagA) status (translocation and phosphorylation) and kinetics of transcription factors [nuclear factor-kappa B (NF-κB) and inhibition kappa B] were investigated in AGS cells co-cultured with HPK5,HPKT510 and its derivative HPK5CA (cagA disruptant) by western blotting analysis with immunoprecipitation.RESULTS:Genetic diversity of the H.pylori cdrA gene demonstrated that the cdrA status segregated into two categories including four allele types,cdrA-positive (allele types;Ⅰand Ⅱ) and cdrA-negative (allele types;Ⅲ and Ⅳ) categories,respectively.Almost all Japanese isolates were cdrA-positive (Ⅰ:7.8% and Ⅱ:90.2%),whereas 16.9% of American isolates were cdrA-positive (Ⅱ) and 83.1% were cdrA-negative (Ⅲ:37.7% and Ⅳ:45.5%),indicating extended diversity of cdrA in individual American isolates.Comparison of each isolate from different regions (antrum and corpus) in the stomach of 29 Americans revealed that cdrA status was identical in both isolates from different regions in 17 cases.However,12 cases had a different cdrA allele and 6 of them exhibited a different cdrA category between two regions in the stomach.Furthermore,in 5 of the 6 cases possessing a different cdrA category,cdrA-negative isolate existed in the corpus,suggesting that cdrA-negative strain is more adaptable to colonization in the corpus.IL-8 secretions from AGS revealed that IL-8 levels induced by a cdrA-disrupted HPKT510 was significantly lower (P < 0.01) compared to wildtype HPK5:corresponding to 50%-60% of those of wild-type HPK5.These data coincided with in vivo data that an average value of IL-8 in biopsy specimens from cdrA-positive and cdrA-negative groups was 215.6 and 135.9 pg/mL,respectively.Western blotting analysis documented that HPKT510 had no effect on CagA translocation and phosphorylation,however,nuclear accumulation of NF-κB was lower by HPKT510 compared to HPK5.CONCLUSION:Colonization by a cdrA-negative or cdrA-dysfunctional strain resulted in decreased IL-8 production and repression of NF-κB,and hence,attenuate the host immunity leading to persistent infection. | Hiroaki Takeuchi Ya-Nan Zhang Dawn A Israel Richard M Peek Jr Mikio Kamioka Hideo Yanai Norihito Morimoto Tetsuro Sugiura | 2012 | World Journal of Gastroenterology2012，18，5： | 3 |
| 3 | Isolated small bowel transplantation outcomes and the impact of immunosuppressants: Experience of a single transplant center显示文摘AIM: To investigate patient and graft outcomes in isolated small bowel transplant(SBTx) recipients and immunosuppressant induction agent impact on outcomes.METHODS: A retrospective review of the perioperative data of patients who underwent SBTx transplant during an 8-year period was conducted. The intraoperative data were: patient demographics, etiology of short gut syndrome, hemodynamic parameters, coagulation profiles, intraoperative fluid and blood products transfused, and development of post-reperfusion. The postoperative data were: hospital/intensive care unit stays, duration of mechanical ventilation, postoperative incidence of acute kidney injury, and 1-year patient and graft outcomes. The effects of the three immunosuppressant induction agents(Zenapax, Thymoglobulin, Campath) on patient and graft outcomes were reviewed.RESULTS: During the 8-year period there were 77 patients; 1-year patient and graft survival were 95% and 86% respectively. Sixteen patients received Zenapax, 22 received Thymoglobulin, and 39 received Campath without effects on patient or graft survival(P = 0.90, P = 0.14, respectively). The use of different immune induction agents did not affect the incidence of rejection and infection during the first 90 postoperative days(P = 0.072, P = 0.29, respectively). The Zenapax group received more intraoperative fluid and blood products and were coagulopathic at the end of surgery. Zenapax and Thymoglobulin significantly increased serum creatinine at 48 h(P = 0.023) and 1 wk(P = 0.001) post-transplant, but none developed renal failure or required dialysis at the end of the first year.CONCLUSION: One-year patient and graft survival were 95% and 86%, respectively. The use of different immunosuppressant induction agents may affect the intraoperative course and short-term postoperative morbidities, but not 1-year patient and graft outcomes. | Ibtesam A Hilmi Raymond M Planinsic Ramona Nicolau-Raducu Daniela Damian Ali Al-Khafaji Tetsuro Sakai Kareem Abu-Elmagd | 2013 | World Journal of Transplantation2013，3，4： | 2 |
| 4 | Genetic characterization of a novel Tib-derived variant of soybean Kunitz trypsin inhibitor detected in wild soybean (Glycine soja ) 显示文摘 | WANG K J TETSURO Y MASAO W et a l | 2004 | Genome2004，47，： | 1 |
| 5 | NOX4 as the major catalytic component of an endothelial NAD(P)H oxidase显示文摘 | Tetsuro A Takanari K Hiroaki O Teruaki I Youn HH Junichi T | 2004 | Circulation2004，109，： | 1 |
| 6 | NOX4 as the major catalytic component of an endothelial NAD(P)H oxidase 显示文摘 | Tetsuro A Takanari K I-Iiroaki O | 2004 | Circulation2004，109，： | 1 |
| 7 | Prevention ofhepatocarcinogenesis with phosphatidylcholine and menaqui-none-4:In vitro and in vivo experiments显示文摘 | Sakakima Y Hayakawa A Tetsuro N | 2007 | Journal of Hep-atology2007，47，1： | 1 |
| 8 | Development and utilization of a new mechanized cabbage harvestingsystem for large fields显示文摘 | Mitsuru Hachiya Tetsuro Amano Makoto Yamagata A | 2004 | JARQ2004，38，2： | 1 |
| 9 | Pseudo-accoramodation with intraocular lenses im- planted in the bag显示文摘 | Altan-Yaycioglu R Gozum N Gucukoglu A Jorge L Tetsuro O Tatsuya M | 2002 | JRefrat Surg2002，18，3： | 1 |
| 10 | Pathologic Features of Mucin-producing Bile Duct Tumors: Two Histopathologic Categories as Counterparts of Pancreatic Intraductal Papillary-mucinous Neoplasms显示文摘 | Hiroaki Shibahara Shugo Tamada Masamichi Goto Koji Oda Masato Nagino Tetsuro Nagasaka Surinder K Batra Michael A Hollingsworth Kohzoh Imai Yuji Nimura Suguru Yonezawa | 2004 | The American Journal of Surgical Pathology2004，，3： | 1 |
| 11 | NOX4 as the major catalytic component of an endothelial NAD(P)H oxidase显示文摘 | TAKANARI K HIROAKI O | 2004 | Circulation2004，109，： | 1 |
| 12 | Ocular and systemic factors relevant to diabetic keratoepitheliopathy显示文摘 | Kenji I Satoshi K Chika O Jiro N Shiro A Tetsuro O | 2001 | Coma2001，20，8： | 1 |
| 13 | Advanced glycation end products inhuman optic nerve head显示文摘 | Shiro A Yuichi K Tetsuro O | 2001 | Clin Sci2001，85，1： | 1 |
| 14 | Grape Seed Extract acting on astrocytes reveals neuronal protection against oxidative stress via interleukin-6-mediated mechanisms 显示文摘 | KAYOKO F A TETSURO O KEISUKE S | 2009 | Cell Mol Neurobiol2009，21，5： | 1 |
| 15 | Application of sliding-mode theory to direct yaw-moment control 显示文摘 | Tohru Y Tomohiko A Tetsuro B | 1999 | JSAE Review1999，20，4： | 1 |
| 16 | Vaticanol C,a Novel Resveratrol Tetramer,Inhibits Cell Growth through Induction of Apoptosis in Colon Cancer Cell Lines显示文摘 | Yukihiro A Toshiyuki T | 2002 | Biol Pharm Bull2002，25，1： | 1 |
| 17 | Novel acrylic/polyester system for powder coatings 显示文摘 | Goro L Tetsuro A Kazuyoshi M | 1999 | Paint India1999，31，2： | 1 |
| 18 | Triterpenes of Poria cocos 显示文摘 | Takaaki T Akira A Tetsuro S | 1993 | Phytochemistry1993，32，5： | 1 |
| 19 | Broadband multimode baffled piezoelectric cylindrical shell trans- ducers显示文摘 | TETSURO O BORIS A DAVID A B | 2007 | The Journal of the Acoustical Society of A- merica2007，121，6： | 1 |
| 20 | Risk factors predisposing to stroke recurrence within one year of non-cardioembolic stroke onset: the Fukuoka Stroke Registry显示文摘 | Kuwashiro T Hiroshi S Tetsuro A | 2012 | Cerebrovasc Dis2012，33，2： | 1 |
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