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| 1 | Current and future applications of in vitro magnetic resonance spectroscopy in hepatobiliary disease显示文摘原子磁性的回声光谱学允许细胞的生物化学和新陈代谢的学习,在整个身体在活体内并且在更高的磁场力量在试管内。因为这种技术非侵略、非选择,磁性的回声光谱学方法论广泛地在生物化学和药被使用了。房间,身体液体和纸巾的在试管内磁性的回声光谱学研究在医药生物化学被使用了调查 pathophysiological 过程,更最近,这种技术被医生使用了决定疾病畸形在活体内。这个加亮的话题说明在试管内的潜力在学习肝胆管系统的磁性的回声光谱学。在恶意、非恶意的肝疾病和胆汁作文的学习的磁性的回声光谱学学习的在试管内质子和磷的角色被讨论,特别地与关联词在活体内的参考整个身体的磁性的回声光谱学应用。在摘要,磁性的回声光谱学技术能在到内在的 pathophysiological 过程的疾病严厉和指针上提供非侵略的生物化学的信息。磁性的回声光谱学为疾病简历标记,以及估计的治疗学的反应作为一个屏蔽工具保持潜在的诺言。 | I Jane Cox Amar Sharif Jeremy FL Cobbold Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，30： | 10 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | Achieving Effective Implementation and Evaluation of a Collaborative Land Use Planning Process显示文摘 | Albert Karin H Thomas I Gunton J C Day | 2004 | Environments2004，31，3： | 1 |
| 4 | Alkali treatment for rapid preparation of plant material for reliable PCR analysis显示文摘 | Klimyuk V I Carroll BJ Thomas C M | 1993 | Plant J1993，，3： | 1 |
| 5 | Ipilimumab plus dacar- bazine for previously untreated metastatic melanoma显示文摘 | Robert C Thomas L Bondarenko I | 2011 | N Engl J Med2011，364，26： | 1 |
| 6 | Ipilimumab plus da-carbazine for previously untreated metastatic melanoma显示文摘 | Robert C Thomas L Bondarenko I | 2011 | N Engl J Med2011，364，26： | 1 |
| 7 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 8 | Poly ( amidoamine ) Dendrimer-Based Multifunctional Engineered Nanodevice for Cancer Therapy 显示文摘 | Majoros I J Thomas T P Mehta C B | 2005 | Journal of Medicinal Chemistry2005，48，： | 1 |
| 9 | Genetic discontinuity reveal by chloroplast mierosatellite in eastern north American abies(Pinaceae) 显示文摘 | Catherine M C I Thomas R W David M M | 2000 | American Journal of Botany2000，87，： | 1 |
| 10 | Ipilimumab plus dacarbazine for previously untreated metastatic melanoma显示文摘 | ROBERT C THOMAS L BONDARENKO I | | 0，，26： | 1 |
| 11 | Mechanical Characterization of Rubble Stone Masonry Walls Using Non and Minor Destructive Tests 显示文摘 | Lombillo I Thomas C Villegas L | 2015 | Construction and Building Materials2015，43，26： | 1 |
| 12 | Ipilimumab plus dacarbazine for previously untreated metastatic melanoma 显示文摘 | ROBERT C THOMAS L BONDARENKO I | 2011 | N Engl J Med2011，364，25： | 1 |
| 13 | Application of a hexapole collision and reaction cell in ICP-MS Part Ⅱ:Analytical figures of merit and first applications显示文摘 | FELDMANN I JAKUBOWSKI N THOMAS C | 1999 | Fresenius'' Journal of Analytical Chemistry1999，365，5： | 1 |
| 14 | Metallo-organic compounds containing metal-nitrogen bonds (part Ⅲ): Dialkylamino compounds of tantalum显示文摘 | Bradley D C Thomas I M | 1962 | Can J Chem1962，40，7： | 1 |
| 15 | Hippocampal Neurotoxicity of △9-Tetrahydrocannabinol显示文摘 | Guy Chiu-Kai C Thomas R Soren I | 1998 | J Neurosci1998，18，： | 1 |
| 16 | The use of nucleic acid amplification techniques to increase the viral safety of blood显示文摘 | Thomas I Mathys E Gerard C | 2002 | Clin Lab2002，48，： | 1 |
| 17 | Prevalence of human erythrovirus B19 DNA in healthy Belgian blood donors and correlation with specific antibodies against structural and non-structuctural viral proteins 显示文摘 | Thomas I Di Giambattista M Gerard C | 2003 | Vox Sang2003，84，4： | 1 |
| 18 | Processing, microstructure and property aspects of a spraycastA-Mg-Li-Zr alloy显示文摘 | HOGG S C PALMER I Q THOMAS L Q GRANT P S | 2007 | Acta Materialia2007，55，6： | 1 |
| 19 | Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy显示文摘 | MAJOROS I J THOMAS T P MEHTA C B | | 0，，19： | 1 |
| 20 | Structural evi- dence for a common intermediate in small G protein-GEF re- actions显示文摘 | THOMAS C FRICKE I SCRIMA A | 2007 | Molecular Ce112007，25，： | 1 |
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