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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Direct control of the grid point distribution in meshs generated by elliptic equations显示文摘 | P D Thomas J F Middlecoff | 1980 | AIAA Journal1980，18，6： | 2 |
| 4 | Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients显示文摘 | G Fattovich G Giustina F Degos F Tremolada G Diodati P Almasio F Nevens A Solinas D Mura JT Brouwer H Thomas C Njapoum C Casarin P Bonetti P Fuschi J Basho A Tocco A Bhalla R Galassini F Noventa SW Schalm G Realdi | 1997 | Gastroenterology1997，，2： | 2 |
| 5 | Reoperation for prosthetic aortic valve obstruction in the era of echocardiography: trends in diagnostic testing and comparison with surgical findings显示文摘 | Steven E Girard Fletcher A Miller Thomas A Orszulak Charles J Mullany Samantha Montgomery William D Edwards Henry D Tazelaar Joseph F Malouf A.Jamil Tajik | 2001 | Journal of the American College of Cardiology2001，，2： | 2 |
| 6 | Methods in laboratory investigation normal human urothelial cells in vitro: proliferation and induction of stratification显示文摘 | Southgate J Hutton K A R Thomas D F M | 1994 | Lab Invest1994，71，4： | 2 |
| 7 | Mechanisms of formation damage and permeability impairment associated with the drilling,completion and production of low API gravity oil reservoirs显示文摘 | Thomas F B Bennion D W | 1996 | SPE 303201996，，： | 1 |
| 8 | Preparation and surface properties of acrylic polymers containing fluorinated monomers 显示文摘 | Richard R Thomas D R Anton W F | 1997 | Macromolecules1997，30，： | 1 |
| 9 | Odorous compounds in natural water: 2 - exo - hydroxy - 2 - methyl - bornane, the major odorous compound produced by several actinomycetes 显示文摘 | MEDSKER L L JENKINS D THOMAS J F | 1969 | Environment Science Technology1969，3，6： | 1 |
| 10 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 11 | Thomashow components of the Arabidopsis C repeat/dehydration responsive element bindingfactor cold-response pathway are conserved in Brassica napus and other plant species显示文摘 | KIRSTEN R J SUSANNE K KEENAN L A XIN Z VOLKER H JAMES Z Z THOMAS D MICHAEL F | 2001 | Plant Plzysiology2001，127，3： | 1 |
| 12 | Toxicity criteria of The Radiation Therapy Oncology Group (RTOG) and The European Organization for Research and Treatment of Cancer (EORTC)显示文摘 | James D C Joann S Thomas F P | 1995 | Int J Radiation Ontology Bid Phys1995，31，5： | 1 |
| 13 | Application of heat treatment to enhance permeability in tight gas reservoirs显示文摘 | Jamaluddin A K M Bennion D B Thomas F B | 2000 | JCPT2000，39，11： | 1 |
| 14 | Direct control of the grid point distribution in meshes generated by elliptic equation显示文摘 | Thomas P D Middlecoff J F | 1979 | AIAA Journal1979，18，6： | 1 |
| 15 | Reductions in the productivity of oil and low permeability gas reservoirs due to aque- ous phase trapping 显示文摘 | Bennion D B Bietz R F Thomas F B | 1994 | Journal of Crgstallization Process and Tech- nology1994，33，8： | 1 |
| 16 | Numerical study of steady turbulent flow through bifurcated nozzles in continu- ous casting显示文摘 | Najjar F Thomas B Hershey D | 1995 | Metall Mater Trans B1995，26，4： | 1 |
| 17 | Transient electromag- netic interference in substations显示文摘 | Wiggins C M Thomas D E Nickel F S | 1994 | IEEE Transations on Power Delivery1994，9，4： | 1 |
| 18 | Collapsing glomerulopathy associ ated with inherited mitochondriai injury显示文摘 | Barisoni L Diomedi-Camassei F Santorelli F M Caridi G Thomas D B Emma F | 2008 | Kidney Int2008，74，： | 1 |
| 19 | Comparison of the Accumulation and Protein Binding of Environmental Cadmium in the Gills,Kidney and Liver of Rainbow Trout(Salmo Gairneri Richardson)显示文摘 | Thomas D G CryerA Solbe J F deLG | 1983 | Comp Biochem Physiol1983，76，2： | 1 |
| 20 | Rapamycin Inhibits the Growth and Metastatic Progression of Non-Small Cell Lung Cancer显示文摘 | Boffa DJ Luan F Thomas D | 2004 | Clin Cancer Res2004，10，1： | 1 |
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